个人简介
吴小华教授,上海市优秀学科带头人,上海市医学领军人才。现任复旦大学附属肿瘤医院妇瘤科主任、妇科肿瘤多学科综合治疗组首席专家;中国抗癌协会妇科肿瘤专业委员会主任委员;中华医学会妇科肿瘤专业委员会常委;中国临床肿瘤学会(CSCO)理事,上海市抗癌协会妇科肿瘤专业委员会主任委员;SGO国际委员会委员;美国西北大学医学院客座教授等。曾任IGCS教育委员会委员、亚太地区理事候选人。目前还担任Internatioanl Journal of Gynecological Cancer, Cancer Medicine, Journal of Gynecological Oncology等杂志编委。专业特长:年轻宫颈癌保留生育功能手术(全世界最大数量),晚期卵巢癌复杂肿瘤细胞减灭术(全国手术量第一)。以第一承担人先后负责国家自然科学基金项目、上海市科委科技创新新行动—医学重点研究项目、上海市优秀学科带头人基金、上海市医学领军人才计划基金、上海市科委项目基金等多项基础研究课题;作为主要合作者先后参与科技部国家高技术发展计划(863 计划)、卫生部国家科技支撑计划课题等。发表学术论文 141 篇,其中SCI 收录的学术论文 80余篇。主要研究成果发表于Annals of Oncology, Clinical Cancer Research,Oncogene, Gynecologic Oncology 等国际学术期刊。并且是美国NCCN Framework(宫颈癌、内膜癌分层诊疗)审阅专家、 Journal of Gynecol Oncology、Cancer Medicine, 中华妇产科等杂志编委。多次获得上海市抗癌协会科技一、二等奖、中华医学科技三等奖、上海市医学科技三等奖、中华医学论文奖等奖项。
研究领域
主要从事妇科恶性肿瘤的临床和基础研究
1、 卵巢癌遗传易感性、靶向治疗和耐药机制的研究
2、 晚期卵巢癌术前腔镜评估
3、 卵巢癌术后巩固维持治疗
4、 宫颈癌保留生育功能各种术式比较与新辅助化疗研究
5、 宫颈癌放疗敏感性研究
近期论文
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Wu X#*, Zhu J#, Yin R#, Yang J, Liu J, Wang J, Wu L, Liu Z, Gao Y, Wang D, Lou G, Yang H, Zhou Q, Kong B, Huang Y, Chen L, Li G, An R, Wang K, Zhang Y, Yan X, Lu X, Lu W, Hao M, Wang L, Cui H, Chen Q, Abulizi G, Huang X, Tian X, Wen H, Zhang C, Hou J, MR M. Niraparib maintenance therapy in patients with platinum-sensitive recurrent ovarian cancer using an individualized starting dose (NORA): a randomized, double-blind, placebo-controlled phase III trial, Annals of Oncology. 2021 Apr; 32(4):512-521.
Xu F#, Li J#, Ni M, Cheng J, Zhao H, Wang S, Zhou X*, Wu X*. FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2. Molecular Cancer. 2021 Mar 3; 20(1):45.
Ni M#, Li Jjiajia#, Zhao H#, Xu F, Cheng J, Yu M, Ke G*, Wu X*. BRD4 inhibition sensitizes cervical cancer to radiotherapy by attenuating DNA repair. Oncogene. 2021 Apr;40(15): 2711-2724.
Wu, Y#., Guo, Q#, Ju, X#, Hu Z#, Xia L, Deng Y, Zhao P, Zhang M, Shao Y, Huang S, He X, Wen H*, Wu X*. HNRNPH1-stabilized LINC00662 promotes ovarian cancer progression by activating the GRP78/p38 pathway. Oncogene . 2021 Jul;40(29):4770-4782.
Li X#, Xia L#, Li J, Chen X, Ju X, Wu X*. Reproductive and obstetric outcomes after abdominal radical trachelectomy (ART) for patients with early-stage cervical cancers in Fudan, China. Gynecol Oncol. 2020 May; 157(2):418-422.
Guo Q#, Wu Y#, Guo X, Cao L, Xu F, Zhao H, Zhu J, Wen H, Ju X, Wu X*. The RNA-Binding Protein CELF2 Inhibits Ovarian Cancer Progression by Stabilizing FAM198B. Molecular therapy Nucleic acids. 2020 Oct 15;23:169-184.
Zhang W#, Tan C, Xu M, Wu X*. Primary appendiceal mucinous neoplasm: Gynecological manifestations, management, and prognosis. Gynecol Oncol. 2020 Feb; 156(2):357-362.
Zhang J#, Zheng H#, Gao Y, Lou G, Yin R, Ji D, Li W, Wang W, Xia B, Wang D, Hou J, Yan J, Hei Y, Zhang ZY, Milton A, Wu X*. Phase I Pharmacokinetic Study of Niraparib in Chinese Patients with Epithelial Ovarian Cancer. Oncologist. 2020 Jan; 25(1):19-e10.
Li X#, Li J#, Jiang Z, Xia L, Ju X, Chen X, Wu X*. Oncological results and recurrent risk factors following abdominal radical trachelectomy: an updated series of 333 patients. BJOG. 2019 Aug; 126(9):1169-1174.
Wang S#, Li J#, Xie J#, Liu F, Duan Y, Wu Y, Huang S, He X, Wang Z*, Wu X*. Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway. Oncogene. 2018 Jul; 37(30):4164-4180.