个人简介
复旦大学附属肿瘤医院大肠癌多学科协作组首席专家、复旦大学大肠癌诊治中心主任、上海市抗癌协会大肠癌专业委员会主任委员、上海市疾病控制中心大肠癌专委会主委、CSCO肿瘤营养专委会主委、CSCO大肠癌专委会副主委、中国医师协会MDT专委会副主委、美国临床肿瘤指南(NCCN)中国版专家委员会委员、NCCN大肠癌临床实践指南(中国版)外科执笔人、主要从事结直肠癌基础和临床研究,尤其擅长于大肠癌的手术治疗,是中国著名的大肠癌专家。
主编《结直肠肛门肿瘤》(北京大学出版社,2005)及《循证结直肠肛管肿瘤学》(上海科学技术出版社2015)。主持国家自然科学基金课题、国家863及973、复旦211等重大科研课题,累计经费4200余万。
近5年发表医学论文90余篇,其中SCI 70余篇。2012获得上海市科学技术及教育部科技进步二等奖,2018获上海预防医学会科学技术二等奖,2019获第三届国之名医盛典-卓越建树奖和科教资讯一等奖。
研究领域
大肠癌、胃癌、软组织腹膜后肿瘤、恶性黑色素瘤等腹部肿瘤的手术治疗
局部晚期大肠癌及复发转移性大肠癌的综合治疗
大肠癌的早期筛查、分子生物标志物及复发转移机制研究
大肠癌类器官平台建设与转化治疗
近期论文
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Chen G#, Peng J#, Xiao Q#, Wu HX#, Wu X, Wang F, Li L, Ding P, Zhao Q, Li Y, Wang D, Shao Y, Bao H, Pang Z, Ding KF*, Cai S*, Wang F*, Xu RH*. Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer. J Hemoatol Oncol, 2021; 14(1): 80.
Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Adjuvant Chemotherapy Seemed Not to Have Survival Benefit in Rectal Cancer Patients with ypTis-2N0 After Preoperative Radiotherapy and Surgery from a Population-Based Propensity Score Analysis. Oncologist, 2019; 24(6):803-811.
Zhang S#, Yang Y, Weng W, Guo B, Cai G, Ma Y, Cai S*. Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer. J Exp Clin Cancer Res, 2019; 38(1):14.
Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin (OGN) reverses epithelial to mesenchymal transition and invasiveness in colorectal cancer via EGFR/Akt pathway. J Exp Clin Cancer Res, 2018; 37(1):41.
Hu X#, Li YQ, Li QG, Ma YL, Peng JJ*, Cai SJ*. ITGAE Defines CD8+ Tumor-Infiltrating Lymphocytes Predicting a better Prognostic Survival in Colorectal Cancer. EBioMedicine, 2018; 35:178-188.
Hu X#, Li YQ, Li QG, Ma YL, Peng JJ, Cai SJ*. Osteoglycin-induced VEGF Inhibition Enhances T Lymphocytes Infiltrating in Colorectal Cancer. EBioMedicine, 2018; 34:35-45.
Li Q#, Dai W#, Jia H#, Li Y, Xu Y, Li X*, Cai G*, Cai S*. Prognostic Impact of Hypochloremia in Patients With Stage I to III Colorectal Cancer After Radical Resection. Dis Colon Rectum, 2018; 61(11):1273-1280.
Yang Y#, Weng W#, Peng J#, Hong L#, Yang L, Toiyama Y, Gao R, Liu M, Yin M, Pan C, Li H, Guo B, Zhu Q, Wei Q, Moyer MP, Wang P, Cai S*, Goel A*, Qin H*, Ma Y*. Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor-kappaB, and Up-regulating Expression of MicroRNA-21. Gastroenterology, 2017; 152(4):851-866.
Li Y#, Liang L#, Dai W, Cai G, Xu Y, Li X, Li Q*, Cai S*. Prognostic impact of programed cell death-1 (PD-1) and PD-ligand 1 (PD-L1) expression in cancer cells and tumor infiltrating lymphocytes in colorectal cancer. Mol Cancer, 2016; 15(1):55.
Li Y#, Jia H#, Yu W, Xu Y, Li X, Li Q*, Cai S*. Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection. Int J Cancer, 2016; 139(1):220-31.