王华伟 - 复旦大学 - 粤港澳大湾区精准医学研究院（广州）

个人简介

中科院遗传与发育生物学研究所博士，曾任加州大学圣地亚哥分校医学院病理系博士后及助理研究科学家，于2021年11月全职加入粤港澳大湾区精准医学研究院（广州），担任细胞治疗与免疫治疗研究中心青年研究员、课题组长，组建精准递送与免疫治疗实验室（Laboratory of Precision Delivery and Immunotherapy）。王华伟博士在发育生物学，癌症生物学，细胞工程与肿瘤免疫治疗等方面积累了丰富的研究经验，曾在Nature Biomedical Engineering, Cancer Research, Cell Discovery, PNAS, Nature Communication等重要学术期刊发表过多篇学术论文，申请了多项美国与中国专利并且成功获得了授权与转化。本课题组将与复旦大学林鑫华教授团队紧密合作，聚焦于可编程精准递送载体的研究，利用复旦大学遗传工程国家重点实验室的多个平台例如类器官研究平台，主要针对重大人类疾病例如扩散型恶性肿瘤，开发免疫疗法与细胞疗法的新策略。

研究领域

新型可编程精准递送载体细胞治疗与细胞工程恶性肿瘤的免疫治疗新策略

近期论文

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Wang H*, Alarcón C*, Liu B, Watson F, Searles S, Lee C, et al. Wang, H., Alarcón, C.N., Liu, B. et al. Genetically engineered and enucleated human mesenchymal stromal cells for the targeted delivery of therapeutics to diseased tissue. Nature Biomedical Engineering (2021). (* Co-first author) Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, et al. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discovery. 2018;4:26. Fujimura K*, Wang H*, Watson F, Klemke RL. KRAS Oncoprotein Expression Is Regulated by a Self-Governing eIF5A-PEAK1 Feed-Forward Regulatory Loop. Cancer Research. 2018;78:1444-56. (*Co-first author) Strnadel J*, Wang H*, Carromeu C, Miyanohara A, Fujimura K, Blahovcova E, et al. Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos. Journal of Molecular Neuroscience. 2018;65:351-8. (*Co-first author) Yang L, Jama B, Wang H, Labarta-Bajo L, Zuniga E. I., and Morris G. P. TCRalpha reporter mice reveal contribution of dual TCRalpha expression to T cell repertoire and function. Proc Natl Acad Sci U S A 117, 32574-32583. Noriega-Guerra H, Cruz MC, Ribeiro PRL, Strnadel J, Wang H, Klemke RL, et al. ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma. Exp Cell Res. 2018;363:271-82. Liu C, Han TX, Stachura DL, Wang H, Vaisman BL, Kim J, et al. Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Communication. 2018;9. Gilder AS, Natali L, Van Dyk DM, Zalfa C, Banki MA, Pizzo DP, Wang H, et al. The Urokinase Receptor Induces a Mesenchymal Gene Expression Signature in Glioblastoma Cells and Promotes Tumor Cell Survival in Neurospheres. Sci Rep. 2018;8:2982. Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, et al. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Res. 2017;77:1997-2007. Fang J, Wang H, Miao L, Kuang X, Ma W, Wang C, et al. Involvement of Protein Acyltransferase ZDHHC3 in Maintaining Oocyte Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2016;95:67. Wang H, Fang JS, Kuang X, Miao LY, Wang C, Xia GL, et al. Activity of Long-Chain Acyl-CoA Synthetase Is Required for Maintaining Meiotic Arrest in Xenopus laevis. Biology of Reproduction. 2012;87.