张志文 - 复旦大学

个人简介

教育经历 2005.09-2008.06，复旦大学，药剂学，博士 2002.09-2005.06，沈阳药科大学，药剂学，硕士 1998.08-2002.06，山东大学，药学，本科工作经历 2022.03-至今复旦大学，药学院，研究员 2015.11-2022.02 中国科学院上海药物研究所，制剂研究中心，研究员 2010.11-2015.10 中国科学院上海药物研究所，制剂研究中心，副研究员 2008.07-2010.10 中国科学院上海药物研究所，制剂研究中心，助理研究员获奖及荣誉中国科学院王宽诚人才奖（2015）中国科学院青年创新促进会优秀会员（2016）国家人才计划青年拔尖人才（2020）中国药学会科学技术奖一等奖（2015.3；2020.2）国家自然科学二等奖（2020.4）

研究领域

主要致力于克服瘤内递送屏障的药物新型递释系统研究

近期论文

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Yuqi Wang#, Honglei Xie#, Yao Wu#, Shuzhou Xu, Yongping Li, Jie Li, Xiaoxuan Xu, Siling Wang*, Yaping Li*, Zhiwen Zhang*. Bioinspired lipoproteins of furoxans-oxaliplatin remodels physical barriers in tumor to potentiate T-cell infiltration.Adv Mater2022, 34, 2110614. Zhiwan Wang#, Xiang Gong#, Jie Li, Hong Wang, Xiaoxuan Xu, Yaping Li, Xianyi Sha, Zhiwen Zhang*. Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity. ACS Nano 2021, 15: 5405–5419. Hong Wang, Jie Li, Zhiwan Wang, Yuqi Wang, Xiaoxuan Xu, Xiang Gong, Jiaoying Wang, Zhiwen Zhang*, Yaping Li*. Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy. Biomaterials 2021, 269, 120609 Jie Li, Hong Wang, Yuqi Wang, Xiang Gong, Xiaoxuan Xu, Xianyi Sha, Ao Zhang*, Zhiwen Zhang*, Yaping Li*. Tumor-activated size-enlargeable bioinspired lipoproteins access cancer cells in tumor to elicit anti-tumor immune responses.Adv Mater2020, 2002380 Jing Wang, Yuqi Wang, Haiqiang Cao, Hong Wang, Jie Li, Youxin Li, Yaping Li*, Zhiwen Zhang*. Orally delivered legumain-activated nanovehicles improve tumor accumulation and penetration for combinational photothermal-chemotherapy. J Control Release2020, 323: 59-70. Junjing Yin, Haiqiang Cao, Hong Wang, Kaoxiang Sun*, Yaping Li, Zhiwen Zhang*. Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy. Acta Pharm Sin B, 2020,10: 2246-2257. Tao Tan, Yuqi Wang, Haiyan Hu, Hong Wang, Jie Li, Zhiwan Wang, Jing Wang, Siling Wang, Zhiwen Zhang*, Yaping Li*. Bioinspired lipoproteins-mediated photothermia remodels tumor stroma to improve cancer cell accessibility of second nanoparticles.Nat Commun. 2019, 10: 3322. Bin He, Tao Tan, Hong Wang, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Kaoxiang Sun, Zhiwen Zhang*, Yaping Li*. Rational Design of Tumor Microenvironment-Activated Micelles for Programmed Targeting of Breast Cancer Metastasis. Adv Funct Mater 2018, 28, 1705622. Haiqiang Cao, Hong Wang, Xinyu He, Tao Tan, Haiyan Hu, Zhiwan Wang, Jing Wang, Jie Li, Zhiwen Zhang*, Yaping Li*. Bioengineered macrophages can responsively transform into nanovesicles to target lung metastasis. Nano Lett 18(2018):4762-70. Haiqiang Cao, Lili Zou, Bin He, Lijuan Zeng, Yongzhuo Huang, Haijun Yu, Pengcheng Zhang, Qi Yin, Zhiwen Zhang*, Yaping Li*. Albumin Biomimetic Nanocorona Improves Tumor Targeting and Penetration for Synergistic Therapy of Metastatic Breast Cancer. Adv Funct Mater 2017, 27, 1605679.

学术兼职

中国药学会纳米药物专业委员会委员中国抗癌协会纳米肿瘤专业委员会委员中国药学会药剂学专业委员会青年委员 Asian Journal of Pharmaceutical Science 青年编委第七届市知联会会员