个人简介
复旦大学药学院青年研究员PI，博士生导师，入选上海“海外高层次人才引进计划”和“高校青年英才揽蓄工程”。博士毕业于新西兰奥塔哥大学药学院，研究领域为群体药代动力学药效学和定量系统药理学，师从本领域著名专家Stephen Duffull教授。已主持国家自然科学基金等各类基金项目3项，荣获2019年度国家优秀自费留学生奖和2019年大洋洲临床和实验药理学家毒理学家学会Fred Fastier奖，曾在2019年欧洲定量药理学年会(PAGE)的Stuart Beal方法学专题做大会报告。近年来以第一作者/通讯作者在Adv. Sci., Br. J. Pharmacol.(4篇), J. Antimicrob. Chemother., Antimicrob. Agents Chemother.等国际权威期刊发表高水平科研论文20余篇，并参与多项CDE指导原则的编写。现为中国药理学会定量药理专委会委员，中国药理学会临床药理专委会青年委员，中国药理学会药物代谢专委会青年委员，上海药理学会临床药理专委会委员，上海药理学会药物代谢专委会委员，DIA中国临床药理工作组南组组长。任《群体药动学和药效学分析进阶》一书副主编。积极投身于定量药理学在中国的教育推广，创办有微信公众号“PKPD”。
教育经历
奥塔哥大学 2016/03 – 2019/05 定量药理学博士
导师: Stephen Duffull教授, Michelle Glass教授
香港中文大学 2012/08 – 2015/09 药学硕士
导师: Lam Tai-ning教授, 左中教授
北京大学/辉瑞定量药理学教学中心 2015/02 – 2015/07 交换生
导师: 卢炜教授, 周田彦教授
复旦大学 2008/09 – 2012/07 药学理学学士
工作经历
2021/07 至今 复旦大学药学院青年研究员
2020/03 – 2021/06 默多克儿童研究所Honorary Fellow
2019/11 – 2020/12 奥塔哥定量药理组Postdoctoral Fellow
导师: Stephen Duffull教授, Amanda Gwee医生
2019/06 – 2019/10 奥塔哥定量药理组Assistant Research Fellow
2015/10 – 2016/02 葛兰素史克中国上海研发中心临床药理建模仿真部门实习生
导师: 马培敏博士, 吴凯博士
荣誉及奖励
2022 复旦大学“钟扬式教学团队”成员
2022 上海“高校青年英才揽蓄工程”入选者
2021 上海“海外高层次人才引进计划”入选者
2020 国家优秀自费留学生奖学金
2019 ASCEPT New Zealand Fred Fastier Prize
2019 ASCEPT and PAGANZ Student Travel Grants
2019 International Society of Pharmacometrics (ISoP) Student Prize for pharmacometrics, PAGANZ Meeting 2019, 奥克兰, 新西兰
2019 奥塔哥大学药学院2018年度最佳科研论文
近期论文
查看导师新发文章
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Liang Yang; Xiao Zhu*; David B Finlay; Hayley Green; Michelle Glass; Stephen B Duffull; A kinetic model for positive allosteric modulator (PAM)-antagonists for the type 1 cannabinoid receptor (CB1), British Journal of Pharmacology, 2023, doi:10.1111/bph.16158
Chong Cao; Hang Yin; Biao Yang; Qi Yue; Guoqing Wu; Meng Gu; Yuwen Zhang; Yang Fan; Xiaoyan Dong; Ting Wang; Cong Wang; Xiao Zhu*; Ying Mao*; Xiao-Yong Zhang*; Zuhai Lei*; Cong Li*; Intra-operative Definition of Glioma Infiltrative Margins by Visualizing Immunosuppressive Tumor-Associated Macrophages, Advanced Science (Weinh), 2023; e2304020
Xin Liu; Gehang Ju; Xinyi Huang; Wenyu Yang; Lulu Chen; Chao Li; Qingfeng He; Nuo Xu; Xiao Zhu*; Dongsheng Ouyang*; Escitalopram population pharmacokinetics and remedial strategies based on CYP2C19 phenotype, Journal of affective disorders. 2023; 346:64-74.
Gaoqi Xu#; Dihong Yang#; Chaoneng He; Like Zhong; Junfeng Zhu; Qi Shu; Haiying Ding; Wenxiu Xin; Yinghui Tong; Xiao Zhu*; Luo Fang*; Population pharmacokinetics and toxicity correlation analysis of free and liposome-encapsulated doxorubicin in Chinese patients with advanced breast cancer, Cancer Chemotherapy and Pharmacology, 2023, doi:10.1007/s00280-023-04559-y
Wenyu Yang#; Wenyao Mak#; Amanda Gwee; Meng Gu; Yue Wu; Yufei Shi; Qingfeng He; Xiaoqiang Xiang; Bing Han*; Xiao Zhu*; Establishment and Evaluation of a Parametric Population Pharmacokinetic Model Repository for Ganciclovir and Valganciclovir, Pharmaceutics, 2023, 15(7): 1801
Meng Gu#; An-Ning Li#; Wen-Yao Mak; Fang Dong; Nuo Xu; Jing-Ye Zhang; Yu-Fei Shi; Nan Zheng; Zhi-Jia Tang; Qing-Feng He; Can-Jun Ruan; Wei Guo; Xiao-Qiang Xiang; Chuan-Yue Wang*; Bing Han*; Xiao Zhu*; Population pharmacokinetics of buprenorphine and naloxone sublingual combination in Chinese healthy volunteers and patients with opioid use disorder: Model-based dose optimization, Frontiers in Pharmacology, 2023, 14:1089862
Anning Li #; Wen Yao Mak; Tingyi Ruan; Fang Dong; Nan Zheng; Meng Gu; Wei Guo; Jingye Zhang; Haoxuan Cheng; Canjun Ruan; Yufei Shi; Yannan Zang; Xuequan Zhu; Qingfeng He; Xiaoqiang Xiang; Gang Wang*; Xiao Zhu*; Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function. Frontiers in Pharmacology, 2023;14:1215065
Xin Liu; Gehang Ju; Wenyu Yang; Lulu Chen; Nuo Xu; Qingfeng He; Xiao Zhu*; Dongsheng Ouyang*; Escitalopram Personalized Dosing: A Population Pharmacokinetics Repository Method. Drug Des Devel Ther. 2023;17:2955-2967
Amanda Gwee; Stephen B. Duffull; Andrew J. Daley; Michelle Lim; Susie Germano; Hajira Bilal; Samantha Hall; Nigel Curtis; Xiao Zhu*; Identifying a therapeutic target for vancomycin against staphylococci in young infants, The Journal of Antimicrobial Chemotherapy, 2022, 77(3): 704-710
Xiao Zhu#; Youyou Tao#; Ruilin Zhu*; Dezhi Wu; Wai-Kit Ming; Impact of Hospital Characteristics and Governance Structure on the Adoption of Tracking Technologies for Clinical and Supply Chain Use: Longitudinal Study of US Hospitals,Journal of Medical Internet Research,2022, 24(5): e33742
Xi-Wei Ji#; Xiao Zhu#; Yun Li; Feng Xue; Isabelle Hui San Kuan; Qing-Feng He; Xiang-Rui Meng; Xiao-Qiang Xiang*; Yi-Min Cui*; Bo Zheng*; Model-Informed Drug Development of New Cefoperazone Sodium and Sulbactam Sodium Combination (3:1): Pharmacokinetic/Pharmacodynamic Analysis and Antibacterial Efficacy Against Enterobacteriaceae, Frontiers in Pharmacology, 2022, 13: 856792
Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull; Evaluation of the profiles of CB1 cannabinoid receptor signalling bias using joint kinetic modelling, British Journal of Pharmacology, 2020, 177(15): 3449-3463.
Xiao Zhu#; David B. Finlay#; Michelle Glass*; Stephen B. Duffull*; Model-free and kinetic modelling approaches for characterising non-equilibrium pharmacological pathway activity: Internalisation of cannabinoid CB1 receptors, British Journal of Pharmacology, 2019, 176(14): 2593-2607
Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull; An evaluation of the operational model when applied to quantify functional selectivity, British Journal of Pharmacology, 2018, 175(10): 1654-1668
Xi-Wei Ji; Feng Xue; Zi-Sheng Kang; Wei Zhong; Isabelle Hui-San Kuan; Xi-Ping Yang; Xiao Zhu*; Yun Li; Yuan Lv; Model-informed drug development of benapenem: Pharmacokinetic/Pharmacodynamic cutoff value determination and antibacterial efficacy against enterobacteriaceae, Antimicrobial Agents and Chemotherapy, 2020, 64(3): e01751-19
Siyuan Wang#; Xiao Zhu#; Mengyi Han; Fangran Hao; Wei Lu; Tianyan Zhou*; Mechanistic Pharmacokinetic/Pharmacodynamic Model of Sunitinib and Dopamine in MCF-7/Adr Xenografts: Linking Cellular Heterogeneity to Tumour Burden,The AAPS Journal, 2020, 22(2): 45
Isabelle H. S. Kuan; Daniel F. B. Wright; Stephen B. Duffull; Xiao Zhu*; Understanding the association between metformin plasma concentrations and lactate, British Journal of Clinical Pharmacology, 2020,87(2): 700-701
Ricardo Pe?a-Silva; Stephen B. Duffull; Andrew C. Steer; Sandra X. Jaramillo-Rincon; Amanda Gwee; Xiao Zhu*; Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19, British Journal of Clinical Pharmacology, 2020, 87(3): 1589-1590
Xiao Zhu*; David B. Finlay; Michelle Glass; Stephen B. Duffull; An intact model for quantifying functional selectivity, Scientific Reports, 2019, 9(1): 2557
Xiao Zhu; Jianyuan Deng; Zhong Zuo; Tai Ning Lam*; An Agent-Based Approach to Dynamically Represent the Pharmacokinetic Properties of Baicalein, The AAPS Journal, 2016, 18(6): 1475-1488
Xi-Wei Ji; Xiang-Rui Meng; Qing-Feng He; Xiao-Qiang Xiang; Yufei Shi*; Xiao Zhu*; Foretinib Is Effective against Triple-Negative Breast Cancer Cells MDA-MB-231 In Vitro and In Vivo by Down-Regulating p-MET/HGF Signaling, International Journal of Molecular Sciences, 2023, 24(1):757
Qiu-Yu Jia#; Qing-Feng He#; Li Yao; Min Li; Jia-Ying Lin; Zhi-Jia Tang; Xiao Zhu*; Xiao-Qiang Xiang*; Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview, Molecules, 2022,27(24):8670
其他论文
Amanda L Wilkins; Tony Lai; Xiao Zhu; Srinivas Bolisetty; Roberto Chiletti; Noel Cranswick; Kaya Gardiner; Rodney Hunt; Atul Malhotra; Brendan McMullan; Bhavesh Mehta; Joanna Michalowski; Himanshu Popat; Meredith Ward; Stephen Duffull; Nigel Curtis; Amanda Gwee*; Individualized vancomycin dosing in infants: prospective evaluation of an online dose calculator, International Journal of Antimicrobial Agents, 2023, 61(3): 106728.
Xiaowen Wang; Yiqun Yu; Hongrui Liu; Fengjiao Bu; Chunying Shen; Qingfeng He; Xiao Zhu; Pin Jiang; Bing Han*; Xiaoqiang Xiang*; Prediction of Drug-Drug Interactions with Ensartinib as a Time-Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model. Drug Metab Dispos. 2023;51(11):1515-1526
Chunyang Pan; Yifan Cheng; Qingfeng He; Min Li; Fengjiao Bu; Xiao Zhu; Xiaoyu Li; Xiaoqiang Xiang*; Evaluating the impact of co-administered drug and disease on ripretinib exposure: A physiologically-based pharmacokinetic modeling approach, Chemico-Biological Interactions, 2023, 373: 110400.
Yawen Yuan; Zhihong Li; Ke Wang; Shunguo Zhang; Qingfeng He; Lucy Liu; Zhijia Tang; Xiao Zhu; Ying Chen; Weimin Cai; Chao Peng; Xiaoqiang Xiang*; Pharmacokinetics of Novel Furoxan/Coumarin Hybrids in Rats Using LC-MS/MS Method and Physiologically Based Pharmacokinetic Model, Molecules, 2023, 28(2): 837
Yawen Yuan; Changcheng Chen; Guoling You; Ruen Yao; Xiao Zhu; Xiaoyu Wu; Juan Wu; Wei Zhao; Zhiling Li; Shunguo Zhang*; Simultaneous quantification and pharmacokinetics of vincristine and its major metabolite M1 in Chinese pediatric ALL patients by LC-MS/MS, Journal of Pharmaceutical and Biomedical Analysis, 2023, 234: 115578
Zheng Liu#; Mette Julsgaard#*; Xiao Zhu; Jennifer Martin; Murray L. Barclay; Noel Cranswick; Peter R. Gibson; Richard B. Gearry; Janine van der Giessen; Susan J. Connor; Ourania Rosella; Anne Grosen; Catherine Toong; Emma Flanagan; Jantien W. Wieringa; C. Janneke van der Woude; Sally J. Bell; CARINA Study Group; Timing of live attenuated vaccination in infants exposed to infliximab or adalimumab in utero: A prospective cohort study in 107 children, Journal of Crohn's & Colitis, 2022, 16(12): 1835-1844
Xiwei Ji#; Xiangrui Meng#; Xiao Zhu; Qingfeng He; Yimin Cui*; Research and development of Chinese anti-COVID-19 drugs, Acta Pharmaceutica Sinica. B, 2022
Qingfeng He#; Fengjiao Bu#; Qizhen Wang; Min Li; Jiaying Lin; Zhijia Tang; Wen Yao Mak; Xiaomei Zhuang; Xiao Zhu; Hai-shu Lin*; Xiaoqiang Xiang*; Examination of the Impact of CYP3A4/5 on Drug–Drug Interaction between Schizandrol A/Schizandrol B and Tacrolimus (FK-506): A Physiologically Based Pharmacokinetic Modeling Approach, International Journal of Molecular Sciences, 2022, 23(9): 4485
Yawen Yuan#; Qingfeng He#; Shunguo Zhang; Min Li; Zhijia Tang; Xiao Zhu; Zheng Jiao; Weimin Cai*; Xiaoqiang Xiang*; Application of Physiologically-based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs, Frontiers in Pharmacology, 2022, 13: 895556
Zhipin Jin#; Qingfeng He#; Xiao Zhu; Mingshe Zhu; Yike Wang; Xin-an Wu; Qianzhou Lv*; Xiaoqiang Xiang*; Application of physiologically based pharmacokinetic modelling for the prediction of drug–drug interactions involving anlotinib as a perpetrator of cytochrome P450 enzymes, Basic & Clinical Pharmacology & Toxicology, 2022, 130(5): 592-605
Zhen Feng; Xiaoye Li; Wai Kei Tong; Qingfeng He; Xiao Zhu; Xiaoqiang Xiang; Zhijia Tang*; Real-world safety of PCSK9 inhibitors: A pharmacovigilance study based on spontaneous reports in FAERS,Frontiers in Pharmacology, 2022; 13: 894685
Jinxin Zhao; Xiao Zhu; Songwen Tan*; Chuanpin Chen*; Amal Kaddoumi*; Xiu-Li Guo*; Yu-Wei Lin*; S Y Amy Cheung*; Editorial: Model-informed drug development and evidence-based translational pharmacology, Frontiers in Pharmacology, 2022; 13: 1086551
Jiaying Lin; Min Li; Wenyao Mak; Yufei Shi; Xiao Zhu; Zhijia Tang; Qingfeng He; Xiaoqiang Xiang; Applications of In Silico Models to Predict Drug-Induced Liver Injury, Toxics, 2022;10(12):788
Min Li#; Qingfeng He#; Li Yao; Xiaofeng Wang; Zhijia Tang; Xiao Zhu; Hai-Shu Lin*; Xiaoqiang Xiang*; Simultaneous Quantification of Propylthiouracil and Its N-β-d Glucuronide by HPLC-MS/MS: Application to a Metabolic Study, Pharmaceuticals, 2021, 14(11): 1194
Liang Yang*; Xiao Zhu; David B. Finlay; Michelle Glass; Stephen B. Duffull; Exploring group size for statistical analysis of real-time signalling experiments, British Journal of Pharmacology, 2021, 178(19):3997-4004
Xiao-Qin Liu#; Yi-Wei Yin#; Chen-Yu Wang; Zi-Ran Li; Xiao Zhu; Zheng Jiao*; How to handle the delayed or missed dose of rivaroxaban in patients with non-valvular atrial fibrillation: model-informed remedial dosing, Expert Review of Clinical Pharmacology, 2021, 14(9): 1153-1163
Courtney Brusamarello; Andrew J. Daley; Xiao Zhu; Cornelia Landersdorfer; Amanda Gwee*; How important are MIC determination methods when targeting vancomycin levels in patients with Staphylococcus aureus infections? The Journal of Antimicrobial Chemotherapy,2021, 76(6): 1641-1643
Zi-Ran Li; Chen-Yu Wang; Xiao Zhu; Zheng Jiao*; Population Pharmacokinetics of Levetiracetam: A Systematic Review, Clinical Pharmacokinetics, 2021, 60(3): 305-318
Amanda Gwee*; Stephen Duffull; Xiao Zhu; Steven Y. C. Tong; Noel Cranswick; Brett McWhinney; Jacobus Ungerer; Joshua Francis; Andrew C. Steer; Population pharmacokinetics of ivermectin for the treatment of scabies in Indigenous Australian children, PLoS Neglected Tropical Diseases, 2020, 14(12): e0008886
Liang Yang; Ling Yong; Xiao Zhu; Yaoyao Feng; Yu Fu; Daming Kong; Wei Lu; Tian-Yan Zhou*; Disease progression model of 4T1 metastatic breast cancer. Journal of Pharmacokinetics and Pharmacodynamics, 2020, 47(1): 105-116
Zheng Liu*; Peter Galettis; Samantha J. Broyd; Hendrika van Hell; Lisa-Marie Greenwood; Peter de Krey; Amy Steigler; Xiao Zhu; Jennifer Schneider; Nadia Solowij; Jennifer H. Martin; Model-based analysis on systemic availability of coadministered cannabinoids after controlled vaporised administration, Internal Medicine Journal,2019, 50(7): 846-853
Xi-Wei Ji#; Shuang-Min Ji#; Xiao-Rong He; Xiao Zhu; Rong Chen; Wei Lu*; Influences of renal function descriptors on population pharmacokinetic modeling of vancomycin in Chinese adult patients. Acta Pharmacologica Sinica, 2018, 39(2): 286-293
Jianyuan Deng; Anika Jhandey; Xiao Zhu; Zhibo Yang; Kin Fu Patrick Yik; Zhong Zuo; Tai Ning Lam*; In silico drug absorption tract: An agent-based biomimetic model for human oral drug absorption, PloS One, 2018, 13(8): e0203361
Yu-Si Chen#; Zi-Qi Liu#; Rong Chen; Lei Wang; Ling Huang; Xiao Zhu; Tian-Yan Zhou; Wei Lu*; Ping Ma*; Population pharmacokinetic analysis of tacrolimus in Chinese myasthenia gravis patients, Acta Pharmacologica Sinica, 2017, 38(8): 1195-1204
Jianyuan Deng; Xiao Zhu; Zongmeng Chen; Chun Ho Fan; Him Shek Kwan; Chi Ho Wong; Ka Yi Shek; Zhong Zuo; Tai Ning Lam*; A Review of Food-Drug Interactions on Oral Drug Absorption, Drugs, 2017, 77(17): 1833-1855
Fangran Hao; Siyuan Wang; Xiao Zhu; Junsheng Xue; Jingyun Li; Lijie Wang; Jian Li; Wei Lu; Tianyan Zhou*; Pharmacokinetic-Pharmacodynamic Modeling of the Anti-Tumor Effect of Sunitinib Combined with Dopamine in the Human Non-Small Cell Lung Cancer Xenograft, Pharmaceutical Research, 2017, 34(2): 408-418
Xi-Wei Ji#; Shuang-Min Ji#; Run-Tao Li; Ke-Hua Wu; Xiao Zhu; Wei Lu*; Tian-Yan Zhou*; Pharmacokinetic-pharmacodynamic modeling of the antitumor effect of TM208 and EGFR-TKI resistance in human breast cancer xenograft mice, Acta Pharmacologica Sinica, 2016, 37(6): 825-833
Lu Wang; Xiao Zhu; Cheng Xie; Ning Ding; Xiaofu Weng; Weiyue Lu; Xunbin Wei*; Cong Li*; Imaging acidosis in tumors using a pH-activated near-infrared fluorescence probe,Chemical Communications,2012, 48(95): 11677-11679
Yile Chen; Xiao Zhu; Yingjia Yu*; Yi Cai; Yan Li; Gengli Duan; Comparison of infrared-assisted extraction and other techniques for analysis of indigo and indirubin in leaves of isatis indigotica fort, Journal of Liquid Chromatography & Related Technologies,2012, 35(3): 362-374
季双敏; 朱校; 高柳村; 杨焕; 高晨燕; 靶介导的药物处置模型研究进展, 中国临床药理学与治疗学, 2018, 23(5): 481-487
季双敏; 朱校*; 靶点介导的药物处置模型在单克隆抗体药物研发中应用的探讨, 中国临床药理学与治疗学, 2018, 23(3): 241-246
学术兼职
中国药理学会定量药理专业委员会，委员
中国药理学会临床药理专业委员会，青年委员
中国药理学会药物代谢专业委员会，青年委员
上海药理学会药物代谢专业委员会，委员
上海药理学会临床药理专业委员会，委员
DIA中国临床药理学工作组南组组长
ISoP, PAGANZ, ASCEPT会员
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