个人简介
教育经历
2000 年-2005 年 日本群马大学医学部 药理学 研究生/博士
1994 年-1997 年 大连医科大学 药理学 研究生/硕士
1989 年-1994 年 大连医科大学 临床医疗系 本科/学士
工作经历
2016 年-现在,复旦大学,药学院,副教授
2014 年-2016 年 国家卫计委 “重大新药创制”科技重大专项实施管理办公室
2008 年-2016 年,复旦大学,药学院,讲师
2006 年-2008 年,复旦大学药学院,药理教研室,博士后
2005 年-2006 年,日本慈惠医科大学,DDS 研究所,研究员
1997 年-2000 年,大连医科大学,药理教研室,讲师
获奖及荣誉
具有独特心脑血管保护作用的一类新药益母草碱(SCM-198)的临床前研究。上海市药学科技奖/二等奖,排名第5
Ι类新药SCM-198(益母草碱)药效学研究和临床前开发。中国药学会科学进步奖/三等奖,排名第5
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
Huang N, Li P, Sun X, Tong L, Dong X, Zhang X, Duan J, Sheng X, Xin H*. TRIM21 mediates the synergistic effect of Olaparib and Sorafenib by degrading BRCA1 through ubiquitination in TNBC. NPJ Breast Cancer. 2023 Oct 20;9(1):85. doi: 10.1038/s41523-023-00588-1.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H*. TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. Life Sci. 2023 May 15;321:121608. doi: 10.1016/j.lfs.2023.121608.
Wu T, Wang M, Ning F, Zhou S, Hu X, Xin H*, Reilly S*, Zhang X*. Emerging role for branched-chain amino acids metabolism in fibrosis. Pharmacol Res. 2023 Jan;187:106604. doi: 10.1016/j.phrs.2022.106604
Huang N, Sun X, Li P, Liu X, Zhang X*, Chen Q*, Xin H*. TRIM family contribute to tumorigenesis, cancer development, and drug resistance. Exp Hematol Oncol. 2022 Oct 19;11(1):75. doi: 10.1186/s40164-022-00322-w.
Yang J, Sun X, Huang N, Li P, He J, Jiang L, Zhang X, Han S*, Xin H*. Entacapone alleviates acute kidney injury by inhibiting ferroptosis. FASEB J. 2022 Jul;36(7):e22399 doi: 10.1096/fj.202200241RR.
Wang M, Zeng F, Ning F, Wang Y, Zhou S, He J, Li C, Wang C, Sun X, Zhang D, Xiao J, Hu P, Reilly S, Xin H*, Xu X*, Zhang X*. Ceria nanoparticles ameliorate renal fibrosis by modulating the balance between oxidative phosphorylation and aerobic glycolysis. J Nanobiotechnology. 2022 Jan 4;20(1):3. doi: 10.1186/s12951-021-01122-w.
Ning FL, Tao J, Li DD, Tian LL, Wang ML, Reilly S, Liu C, Cai H, Xin H*, Zhang XM*. Activating BK channels ameliorates vascular smooth muscle calcification through Akt signaling. Acta Pharmacol Sin. 2022 Mar;43(3):624-633. doi: 10.1038/s41401-021-00704-6.
Han B, Xie W, Zhang Y, Zhou S, Yang J, Wang R, Sun Y, Wang X, Xu J, Chen D, Wang Y, Lu J, Ning F, Shen F, Liu M, Cai H, Xin H*, Lu W*, Zhang X*. The influx/efflux mechanisms of d-peptide ligand of nAChRs across the blood-brain barrier and its therapeutic value in treating glioma. J Control Release. 2020 Nov 10;327:384-396. doi: 10.1016/j.jconrel.2020.08.010.
Ren D, Luo J, Li Y, Zhang J, Yang J, Liu J, Zhang X, Cheng N, Xin H*. Saikosaponin B2 attenuates kidney fibrosis via inhibiting the Hedgehog Pathway. Phytomedicine. 2020 Feb;67:153163.
Wang M#, Xin H#, Tang W, Li Y, Zhang Z, Fan L, Miao L, Tan B, Wang X, Zhu YZ. AMPK Serves as a Therapeutic Target Against Anemia of Inflammation. Antioxid Redox Signal. 2017 Jan 18.
Xin H#, Wang M#, Tang W, Shen Z, Miao L, Wu W, Li C, Wang X, Xin X, Zhu Y. Hydrogen sulfide attenuates inflammatory hepcidin by reducing IL-6 secretion and promoting SIRT1-mediated STAT3 deacetylation. Antioxid Redox Signal. 2016 Jan 10;24(2):70-83.
Xin H, Wang K, Hu G, Xie F, Ouyang K, Tang X, Wang M, Wen D, Zhu Y, Qin X .Establishment and characterization of 7 novel hepatocellular carcinoma cell lines from patient-derived tumor xenografts. PLoS One. 2014 , 9;9(1)