管栋梁 - 中国科学院上海药物研究所 -

个人简介

教育经历 2014.09-2019.07 中国科学院上海药物研究所，药物化学，硕博 2010.09-2014.07 烟台大学药学院，药学，本科工作经历 2024.01-至今中国科学院上海药物研究所，研究员、课题组长 2022.12-2023.12 中国科学院上海药物研究所，副研究员、青年课题组长 2020.11-2022.11 美国RTI International, 博士后 2019.08-2020.11 美国UC San Diego, 博士后

研究领域

抗感染领域合成药物化学，主要针对高风险耐药性微生物开发新型有效的候选药物分子

近期论文

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Dongliang Guan*, Jian Li, Feifei Chen, Jiaqi Li, Xiaolei Bian, Xinxin Feng*, Lefu Lan*, Wei Huang*. A facile and selective derivatization approach on kynurenine-NH2 in daptomycin, leading to the discovery of hexakynomycin to combat multidrug-resistant Gram-positive pathogens especially daptomycin-resistant bacteria. European Journal of Medicinal Chemistry, 2023, 259: 115638. Dongliang Guan, Md Toufiqur Rahman, Elaine A. Gay, Vineetha Vasukuttan, Kelly M. Mathews, Ann M. Decker, Alexander H. Williams, Chang-Guo Zhan, and Chunyang Jin*. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure–Activity Relationship, and Molecular Modeling Studies. Journal of Medicinal Chemistry, 2021, 64(24), 17866-17886. Jian Li, Dongliang Guan (共一), Feifei Chen, Weiwei Shi, Lefu Lan*, Wei Huang*. Total and Semisyntheses of Polymyxin Analogues with 2-Thr or 10-Thr Modifications to Decipher the Structure–Activity Relationship and Improve the Antibacterial Activity. Journal of Medicinal Chemistry, 2021, 64(9), 5746-5765. Dongliang Guan, Feifei Chen, Yunguang Qiu, Bofeng Jiang, Likun Gong, Lefu Lan*, Wei Huang*. Sulfonium, an underestimated moiety for structural modification, alters antibacterial profile of vancomycin against multidrug-resistant bacteria. Angew. Chem., Int. Ed. 2019, 58 (20), 6678-6682. Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan*, and Wei Huang*, Extra Sugar on Vancomycin: New Analogues for Combating Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci. Journal of Medicinal Chemistry 2018, 61 (1), 286-304.