个人简介
教育经历
2007.09 – 2011.06 西北农林科技大学理学院(学士,应用化学专业)
2011.09 – 2016.06 西北农林科技大学理学院(博士,化学生物学专业)
工作经历
2016.07 – 2018.12 复旦大学药学院,博士后
2019.01 – 至今 复旦大学药学院,青年副研究员
研究领域
以活性为导向,开展中药活性组分的不对称合成、结构修饰与改造、活性评价等
近期论文
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Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si* and Bang-Guo Wei* Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents. J. Org. Chem. 2019, 84, 11261-11267
Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si* and Bang-Guo Wei* A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone. Tetrahedron 2019, 75, 260-268;
Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si,* Xun Sun and Bang-Guo Wei* Approach to Chiral 1?Substituted Isoquinolone and 3?Substituted Isoindolin-1-one by Addition?Cyclization Process J. Org. Chem. 2018, 83, 9879-9889;
Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si,* Bang-Guo Wei,* and Guo-Qiang Lin Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives Org. Lett. 2018, 20,1090-1093;
Pan Han, Zhu Zhou, Chang-Mei Si,* Xian-Yi Sha, Zheng-Yi Gu,* Bang-Guo Wei,* and Guo-Qiang Lin Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid Org. Lett. 2017, 1,6732-6735;
Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si*, Zhu Zhou, Xun Sun, Bang-Guo Wei* A practical approach to asymmetric synthesis of dolastatin 10. Org. Biomol. Chem., 2017, 15, 6119-6131.
Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si*, Bang-Guo Wei* Asymmetric syntheses of epohelmins A and B by In-mediated allylation. Org. Biomol. Chem., 2016, 14, 10714-10722.
Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition?Cyclization?Deprotection Process. Org. Lett., 2014, 16, 4328-4331.
Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine. J. Org. Chem., 2015, 80, 5824-5833.
Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei* and Guo-Qiang Lin Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A. Org. Chem. Front., 2015, 2,1485-1499.
Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei* An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin. Org. Biomol. Chem., 2017, 15, 649-661.
Lu-Ping Shao#, Chang-Mei Si#, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski,* Bang-Guo Wei* and Guo-Qiang Lin Synthesis and structure revision of symplocin A Org. Chem. Front., 2017, 4, 995–1004. (# co-first author)