个人简介

Arthur C. Cope Senior Scholar Award, American Chemical Society, 2005 I-APS Award in Photochemistry, Inter-American Photochemical Society, 2003 Alfred P. Sloan Foundation Fellow, 1975 Camille and Henry Dreyfus Teacher-Scholar Award, 1973

研究领域

Physical Organic Chemistry

Our research is directed toward understanding the relationship between the unique structure of DNA and its interaction with light. The foundation for these studies is the design, synthesis, and characterization of short stable DNA base pair domains. Incorporation of organic chromophores either at the ends or within the interior of synthetic DNA hairpins and dumbbells permits study of the dynamics and efficiency of photoinduced electron transfer, energy transfer, and exciton coupling – all of which are mediated by the helical, π-stacked base pair domain. Our research benefits from extensive collaboration with physical and theoretical chemists interested in the behavior of DNA.

近期论文

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Pan, Z. Z.; McCullagh, M.; Schatz, G. C.; Lewis, F. D., Conformational Control of Thymine Photodimerization in Purine-Containing Trinucleotides. J Phys Chem Lett 2011, 2 (12), 1432-1438. Siegmund, K.; Hariharan, M.; Lewis, F. D., Conformation of a Dodecane DNA Hairpin Linker. Multiple Gauche Bonds Cover the Bases. J Phys Chem B 2011, 115 (13), 3740-3746. Thazhathveetil, A. K.; Trifonov, A.; Wasielewski, M. R.; Lewis, F. D., Increasing the Speed Limit for Hole Transport in DNA. J Am Chem Soc 2011, 133 (30), 11485-11487. Carmieli, R.; Smeigh, A. L.; Conron, S. M. M.; Thazhathveetil, A. K.; Fuki, M.; Kobori, Y.; Lewis, F. D.; Wasielewski, M. R., Structure and Dynamics of Photogenerated Triplet Radical Ion Pairs in DNA Hairpin Conjugates with Anthraquinone End Caps. J Am Chem Soc 2012, 134 (27), 11251-11260. Neelakandan, P. P.; McCullagh, M.; Schatz, G. C.; Lewis, F. D., Electronic Interactions in Helical Stacked Arrays of the Modified DNA Base Pyrrolocytosine. J Phys Chem B 2012, 116 (17), 5199-5204. Neelakandan, P. P.; Pan, Z. Z.; Hariharan, M.; Lewis, F. D., Facially-selective thymine-thymine photodimerization in TTT triads. Photoch Photobio Sci 2012, 11 (6), 889-892. Pan, Z. Z.; Chen, J. Q.; Schreier, W. J.; Kohler, B.; Lewis, F. D., Thymine Dimer Photoreversal in Purine-Containing Trinucleotides. J Phys Chem B 2012, 116 (1), 698-704. Pan, Z. Z.; Hariharan, M.; Arkin, J. D.; Jalilov, A. S.; McCullagh, M.; Schatz, G. C.; Lewis, F. D., Electron Donor-Acceptor Interactions with Flanking Purines Influence the Efficiency of Thymine Photodimerization (vol 133, pg 20793, 2011). J Am Chem Soc 2012, 134 (7), 3611-3611. Patwardhan, S.; Tonzani, S.; Lewis, F. D.; Siebbeles, L. D. A.; Schatz, G. C.; Grozema, F. C., Effect of Structural Dynamics and Base Pair Sequence on the Nature of Excited States in DNA Hairpins. J Phys Chem B 2012, 116 (37), 11447-11458. Thazhathveetil, A. K.; Vura-Weis, J.; Trifonov, A.; Wasielewski, M. R.; Lewis, F. D., Dynamics and Efficiency of Hole Transport in LNA:DNA Hybrid Diblock Oligomers. J Am Chem Soc 2012, 134 (39), 16434-16440. Brazard, J.; Thazhathveetil, A. K.; Vaya, I.; Lewis, F. D.; Gustavsson, T.; Markovitsi, D., Electronic excited states of guanine-cytosine hairpins and duplexes studied by fluorescence spectroscopy. Photoch Photobio Sci 2013, 12 (8), 1453-1459. Carmieli, R.; Thazhathveetil, A. K.; Lewis, F. D.; Wasielewski, M. R., Photoselective DNA Hairpin Spin Switches. J Am Chem Soc 2013, 135 (30), 10970-10973. Chen, J. Q.; Thazhathveetil, A. K.; Lewis, F. D.; Kohler, B., Ultrafast Excited-State Dynamics in Hexaethyleneglycol-Linked DNA Homoduplexes Made of A.T Base Pairs. J Am Chem Soc 2013, 135 (28), 10290-10293. Hariharan, M.; Zheng, Y.; Rybtchinski, B.; Lewis, F. D., Thermal Response of DNA Supramolecular Polymers Assembled with Hydrophobic Sticky Ends. J Phys Chem B 2013, 117 (47), 14649-14654. Lewis, F. D., Distance-Dependent Electronic Interactions Across DNA Base Pairs: Charge Transport, Exciton Coupling, and Energy Transfer. Isr J Chem 2013, 53 (6-7), 350-365. Lewis, F. D.; Wasielewski, M. R., Dynamics and efficiency of photoinduced charge transport in DNA: Toward the elusive molecular wire. Pure Appl Chem 2013, 85 (7), 1379-1387. Markovitsi, D.; Sage, E.; Lewis, F. D.; Davies, J., Interaction of UV radiation with DNA. Photoch Photobio Sci 2013, 12 (8), 1256-1258. Renaud, N.; Berlin, Y. A.; Lewis, F. D.; Ratner, M. A., Between Superexchange and Hopping: An Intermediate Charge-Transfer Mechanism in Poly(A)-Poly(T) DNA Hairpins. J Am Chem Soc 2013, 135 (10), 3953-3963. Jalilov, A. S.; Patwardhan, S.; Singh, A.; Simeon, T.; Sarjeant, A. A.; Schatz, G. C.; Lewis, F. D., Structure and Electronic Spectra of Purine-Methyl Viologen Charge Transfer Complexes. J Phys Chem B 2014, 118 (1), 125-133. Neelakandan, P. P.; Zeidan, T. A.; McCullagh, M.; Schatz, G. C.; Vura-Weis, J.; Kim, C. H.; Wasielewski, M. R.; Lewis, F. D., Ground and excited state electronic spectra of perylenediimide dimers with flexible and rigid geometries in DNA conjugates. Chem Sci 2014, 5 (3), 973-981.