Chen, Xiaoyuan - National University of Singapore - Department of Biomedical Engineering

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Chen, Xiaoyuan Professor 收藏完善纠错
National University of Singapore Department of Biomedical Engineering
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个人简介

02/02-04/04 University of Southern California Assistant Professor of Radiology Research 05/04-08/08 Stanford University Assistant Professor of Radiology 09/08-07/09 Stanford University Associate Professor of Radiology 08/09-07/20 National Institutes of health Senior Investigator and Laboratory Chief 11/20-present National University of Singapore Nasrat Muzayyin Chair Professor in Medicine and Technology

研究领域

Theme 1: Nano-Bio Interfaces A thorough understanding of how nanoparticles interact with tissues and cells in vivo is essential to accelerate the clinical translation process. Various tools will be applied to reveal the mechanisms of nanoparticle transport in vivo, allowing for the development of new strategies for nanomaterial design. Machine learning and artificial intelligence (AI) will also be applied to optimize nanotechnology-based drug delivery, “closing the loop” of nanoparticle synthesis, characterization, refinement and testing or predicting activity in vitro and in vivo. Theme 2: Nanodiagnostics The incorporation of nanobiotechnology with molecular diagnostics (genomic/proteomic/cellomic nanosensors) can be deployed to improve the sensitivity, specificity and accuracy of in vitro diagnostics. Prof. Chen and his colleagues will develop various nanosensor platforms (e.g. magnetic, electrical and optical) to discover and translate novel circulating biomarkers for different clinical applications (e.g., metabolic diseases, neurodegenerative diseases, cancers, and infectious diseases). Theme 3: Nanoimaging Molecular imaging enables us to non-invasively visualize cellular functions and biological processes in living subjects, allowing accurate diagnosis of diseases at early stages. The novel properties of nanoparticles enable molecular imaging to have high resolution and sensitivity. Compared with small molecule-based contrast agents, nanoparticles exhibit excellent biodistribution, long circulation time and other various functions. Furthermore, multifunctional nanomaterials can serve as multimodal imaging agents or theranostic agents. Nevertheless, clinical translation of nanomaterials has been much slower than that of small molecule-based materials. Many critical challenges, including toxicity, biocompatibility, targeting efficacy and long-term stability of nanoparticles, will be addressed in this theme to promote their clinical translation. Theme 4: Nanotherapeutics Nanoparticles is the logical and encouraging tool for delivery of medicine in controlled and targeted manner. Nanotherapeutics are expected to provide targeted drug delivery, improve drug solubility, extend drug half-life, improve a drug’s therapeutic index, and reduce a drug’s immunogenicity, which has the potential to revolutionize the treatment of many diseases. In this theme, Prof. Chen will develop various nanocarriers (e.g. liposome, nanocrystal, virosome, polymer therapeutic, nanoemulsion, and inorganic nanoparticle) for different types of drugs, such as proteins/peptides, chemotherapeutics, RNA therapeutics (e.g. siRNA, mRNA). Theme 5: Nanoimmunomodulation Immunomodulation, that is tuning how the immune system responds to exogenous and endogenous danger stimuli, represents a bubbling field of research in nanomedicine. The complexity under which the immune system operates, however, is staggering. An intricate network of cell types and subtypes direct the concerted actions of the innate and adaptive arms of the immune system. They coordinate, through different signaling molecules, the response against danger signals, and curb, in healthy conditions, the abnormal reaction against self-antigens that arise in autoimmune diseases. The possibilities for nano-enabled immunomodulation are therefore multiple, and so are the challenges. Prof. Chen aims to: 1) apply various nanotechnologies for effective targeting of dendritic cells (DCs) to induce immune tolerance; 2) design nanomedicines to overcome various issues of adoptive T-cell therapy (ACT); 3) develop nanovaccines against cancer and infectious diseases. Theme 6: Translational nanomedicine In this theme, Prof. Chen and his colleagues will tackle key issues related to the clinical development of nanomedicine, including biological challenges, large-scale manufacturing, biocompatibility and safety, government regulations, and overall cost-effectiveness of nanomedicine. It is the ultimate goal of this Center for Nanomedicine to build up the expertise and capability in characterizing various newly developed nanoplatforms, conducting preclinical studies on the nanoformulas for submission to regulatory agencies, scaling up laboratory preparation of nanomaterials according to regulatory and industry standards for early clinical trials, and designing and conducting clinical trials of the de novo nanoplatforms.

近期论文

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Designing nanotheranostics with machine learning. Nat Nanotechnol. 2024 Oct 3. doi: 10.1038/s41565-024-01753-8. Rao L, Yuan Y, Shen X, Yu G, Chen X. Polymeric nanocarrier via metabolism regulation mediates immunogenic cell death with spatiotemporal orchestration for cancer immunotherapy. Nat Commun. 2024 Oct 4;15(1):8586. Guo Y, Li Y, Zhang M, Ma R, Wang Y, Weng X, Zhang J, Zhang Z, Chen X, Yang W. Synthetic nanomaterials for spleen-specific mRNA delivery. Biomaterials. 2024 Sep 28;314:122859. Nie S, Yang B, Ma R, Zha L, Qin Y, Ou L, Chen X, Li L. Synergistic Gas Therapy and Targeted Interventional Ablation With Size-Controllable Arsenic Sulfide (As2S3) Nanoparticles for Effective Elimination of Localized Cancer Pain. Small. 2024 Oct 2:e2407197. Tang Y, Zhang J, Yuan Y, Shen K, Luo Z, Jia L, Long X, Peng C, Xie T, Chen X, Zhang P. Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics. Theranostics. 2024 Sep 9;14(15):5869-5882. Wang L, Dong C, Zhang W, Ma X, Rou W, Yang K, Cui T, Qi S, Yang L, Xie J, Yu G, Wang L, Chen X, Liu Z. Nanozymes in Biomedical Applications: Innovations Originated From Metal-Organic Frameworks. Adv Healthc Mater. 2024 Sep 25:e2402066. Zhao Y, Cheng J, Li Z, Wang J, Chen X. A nanobody-guided multifunctional T cell engager promotes strong anti-tumor responses via synergistic immuno-photothermal effects. J Nanobiotechnology. 2024 Sep 14;22(1):561. Xie S, Shi W, Duan S, Huang X, Liu A, Hou X, Lin X, Zhong D, Sun S, Ding Z, Yang X, Chen X, Lu X. Open-Source Throttling of CD8+ T Cells in Brain with Low-Intensity Focused Ultrasound-Guided Sequential Delivery of CXCL10, IL-2, and aPD-L1 for Glioblastoma Immunotherapy Adv Mater. 2024 Sep 12:e2407235 Dong L, Zhu Y, Zhang H, Gao L, Zhang Z, Xu X, Ying L, Zhang L, Li Y, Yun Z, Zhu D, Han C, Xu T, Yang H, Ju S, Chen X, Zhang H, Xie J. The Landscape of Smart Biomaterial-Based Hydrogen Therapy. Adv Sci (Weinh). 2024 Aug 21:e2401310. Xu M, Wu G, You Q, Chen X. Carrier-Free Nanodrugs: From Bench to Bedside ACS Nano. 2024 Aug 20. doi: 10.1021/acsnano.4c09027. Fang F, Chen X. Disulfidoptosis as a Novel Mechanism of Neuronal Death: Insights from Creutzfeldt-Jakob Disease. World Neurosurg. 2024 Aug 17:S1878-8750(24)01439-6. doi: 10.1016/j.wneu.2024.08.070. Wu Q, Liu SP, Liu C, Chen X, Zhou H, Zhao H. Development of [177Lu]Lu-LNC1010 for peptide receptor radionuclide therapy of nasopharyngeal carcinoma Eur J Nucl Med Mol Imaging. 2024 Aug 15. doi: 10.1007/s00259-024-06874-9. Chen J, Pang Y, Liao X, Zhou Y, Luo Q, Wu H, Zuo C, Zhang J, Lin Q, Chen X, Zhao L, Chen H. Lung ultrasound score evaluation of the effect of pressure-controlled ventilation volume-guaranteed on patients undergoing laparoscopic-assisted radical gastrectomy. World J Gastrointest Surg. 2024 Jun 27;16(6):1717-1725. Tan J, Bao CM, Chen XY. Metal-polyphenol self-assembled nanodots for NIR-II fluorescence imaging-guided chemodynamic/photodynamic therapy-amplified ferroptosis. Acta Biomater. 2024 Jul 23:S1742-7061(24)00388-X. Zhu Y, Ding C, Fang W, Li T, Yan L, Tian Y, Huang W, Wei P, Ma J, Lin X, Huang W, Lin Y, Zou J, Chen X. Targeted Radionuclide Therapy in Glioblastoma. ACS Appl Mater Interfaces. 2024 Aug 7;16(31):40391-40410. Zhao X, Jakobsson V, Tao Y, Zhao T, Wang J, Khong PL, Chen X, Zhang J. Precise Identification of Glioblastoma Micro-Infiltration at Cellular Resolution by Raman Spectroscopy Adv Sci (Weinh). 2024 Jul 31:e2401014. Zhu L, Li J, Pan J, Wu N, Xu Q, Zhou QQ, Wang Q, Han D, Wang Z, Xu Q, Liu X, Guo J, Wang J, Zhang Z, Wang Y, Cai H, Li Y, Pan H, Zhang L, Chen X, Lu G. A Dual-Targeting, Multi-Faceted Biocompatible Nanodrug Optimizes the Microenvironment to Ameliorate Abdominal Aortic Aneurysm. Adv Mater. 2024 Jun 24:e2405761. Mo F, Wang C, Li S, Li Z, Xiao C, Zhang Y, Hu C, Wang E, Lin P, Yuan T, Zuo Z, Fu W, Chen X, Ren L, Wang L. Multifaceted Carbonized Metal-Organic Frameworks Synergize with Immune Checkpoint Inhibitors for Precision and Augmented Cuproptosis Cancer Therapy ACS Nano. 2024 Jun 28. doi: 10.1021/acsnano.4c04022. Zhao C, Tang X, Chen X, Jiang Z. Engineering of a DNA/γPNA Hybrid Nanoreporter for ctDNA Mutation Detection via γPNA Urinalysis Adv Sci (Weinh). 2024 Jul 3:e2310225 Xiang Z, Lu J, Ming Y, Guo W, Chen X, Sun W. Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade. Signal Transduct Target Ther. 2024 Jun 3;9(1):142. Zhao L, Pang Y, Zhou Y, Chen J, Fu H, Guo W, Xu W, Xue X, Su G, Sun L, Wu H, Zhang J, Wang Z, Lin Q, Chen X, Chen H. Manipulating calcium homeostasis with nanoplatforms for enhanced cancer therapy. Exploration (Beijing). 2023 Oct 10;4(1):20230019. doi: 10.1002/EXP.20230019. Feng Y, Wang J, Cao J, Cao F, Chen X. Neuroprotective effects of anti-TRAIL-ICG nanoagent and its multimodal imaging evaluation in cerebral ischemia-reperfusion injury. Mater Today Bio. 2024 May 22;26:101094. doi: 10.1016/j.mtbio.2024.101094. Yang Q, Ye W, Luo D, Xing J, Xiao Q, Wu H, Yao Y, Wang G, Yang L, Guo D, Wang K, He Y, Ye X, Zhang J, Jin Z, Fan Z, Wen X, Mao J, Chen X, Zhao Q. Diagnostic performance and clinical impact of 18F-AlF-NOTA-octreotide in a large cohort of patients with neuroendocrine neoplasms: A prospective single-center study. Theranostics. 2024 May 19;14(8):3213-3220. Hou G, Cheng X, Yang Y, Zhao D, Wang G, Zhao H, Zheng R, Wang X, Chen X, Chi Y, Zhang J. "AquaF" Building Blocks for Water-Compatible SN2 18F-Fluorination of Small-Molecule Radiotracers. J Am Chem Soc. 2024 Jun 13. doi: 10.1021/jacs.4c05854. Mou Z, Zhu Y, Zhang L, Ma M, Li Z, Guo Y, Zheng J, Zhao Z, Zhang K, Chen X, Li Z. Engineered Antibodies as Cancer Radiotheranostics. Adv Sci (Weinh). 2024 Jun 14:e2402361. doi: 10.1002/advs.202402361. Wei Z, Li B, Wen X, Jakobsson V, Liu P, Chen X, Zhang J. Nanomaterial-Based Strategies for Attenuating T-Cell-Mediated Immunodepression in Stroke Patients: Advancing Research Perspectives Int J Nanomedicine. 2024 Jun 12;19:5793-5812. Wang Y, Liu C, Ren Y, Song J, Fan K, Gao L, Ji X, Chen X, Zhao H. Hairpin DNA-Based Nanomaterials for Tumor Targeting and Synergistic Therapy Int J Nanomedicine. 2024 Jun 12;19:5781-5792. Shan L, Li Y, Ma Y, Yang Y, Wang J, Peng L, Wang W, Zhao F, Li W, Chen X Wake biofilm up to enhance suicidal uptake of gallium for chronic lung infection treatment. Biomaterials. 2024 May 17;310:122619. doi: 10.1016/j.biomaterials.2024.122619. He J, Lin X, Zhang D, Hu H, Chen X, Xu F, Zhou M. olyprodrug nanomedicine for chemiexcitation-triggered self-augmented cancer chemotherapy and gas therapy. Biomaterials. 2024 Sep;309:122606. doi: 10.1016/j.biomaterials.2024.122606. Wang Q, Zhang C, Zhao Y, Jin Y, Zhou S, Qin J, Zhang W, Hu Y, Chen X, Yang K. Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging. Theranostics. 2024 Apr 15;14(7):2675-2686 Du Y, Xu J, Han T, Jiang Z, Zhang Y, Li J, Chen X, Zhu S. Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection Theranostics. 2024 Apr 22;14(7):2736-2756 Jiao J, Zhang J, Wen W, Qin W, Chen X. Immunological nanomaterials to combat cancer metastasis. Chem Soc Rev. 2024 May 15. doi: 10.1039/d2cs00968d Pan Y, Cheng J, Zhu Y, Zhang J, Fan W, Chen X. Diagnostic Performance of [18F]AlF-Thretide PET/CT in Patients with Newly Diagnosed Prostate Cancer Using Histopathology as Reference Standard J Nucl Med. 2024 May 9:jnumed.123.266940. doi: 10.2967/jnumed.123.266940. Zang J, Yang Y, Chen S, Wang C, Chen S, Hu S, Cai H, Li X, Xu N, Chen X, Zhang J, Miao W 1088 Carboxylesterase Activatable Molecular Probe for Personalized Treatment Guidance by Analyte-Induced Molecular Transformation Angew Chem Int Ed Engl. 2024 May 10:e202404093. doi: 10.1002/anie.202404093 Li B, Liu H, Zhao M, Zhang X, Huang P, Chen X, Lin J Partial root-zone drying combined with nitrogen treatments mitigates drought responses in rice. Front Plant Sci. 2024 Apr 15;15:1381491. Zhao M, Gao Z, Kuang C, Chen X. A Guanidinobenzol-Rich Polymer Overcoming Cascade Delivery Barriers for CRISPR-Cas9 Genome Editing. Nano Lett. 2024 Apr 29. doi: 10.1021/acs.nanolett.4c00533. Liang S, Ma N, Li X, Yun K, Meng QF, Ma K, Yue L, Rao L, Chen X, Wang Z. Design and Characterization of a New Formulation for the Delivery of COVID-19-mRNA Vaccine to the Nasal Mucosa. Vaccines (Basel). 2024 Apr 12;12(4):409. Altay Benetti A, Tan EYZ, Chang ZW, Bae KH, Thwin MT, Muthuramalingam RPK, Liao KC, Wan Y, Ng LFP, Renia L, Liu J, Chen X, Yang YY, White KP, Pastorin G. Double-Layered Hollow Mesoporous Cuprous Oxide Nanoparticles for Double Drug Sequential Therapy of Tumors. Adv Mater. 2024 Apr 26:e2313212. Li Z, Yang J, Ren B, Fan Q, Huang L, Guo S, Zhou R, Chen S, Feng J, Yan C, Chen X, Shen Z. Expression of concern: Gadolinium embedded iron oxide nanoclusters as T1-T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery. Nanoscale. 2024 Apr 25. doi: 10.1039/d4nr90085e. Wang X, Zhou Z, Wang Z, Xue Y, Zeng Y, Gao J, Zhu L, Zhang X, Liu G, Chen X. A mesoporous superparamagnetic iron oxide nanoparticle as a generic drug delivery system for tumor ferroptosis therapy. J Nanobiotechnology. 2024 Apr 24;22(1):204. Yang J, Xiong W, Huang L, Li Z, Fan Q, Hu F, Duan X, Fan J, Li B, Feng J, Xu Y, Chen X, Shen Z. Programming peptide-oligonucleotide nano-assembly for engineering of neoantigen vaccine with potent immunogenicity. Theranostics. 2024 Mar 17;14(6):2290-2303 Xiang Z, Lu J, Rao S, Fu C, Yao Y, Yi Y, Ming Y, Sun W, Guo W, Chen X. Theranostics - a sure cure for cancer after 100 years? Theranostics. 2024 Mar 31;14(6):2464-2488. doi: 10.7150/thno.96675 Song Y, Zou J, Castellanos EA, Matsuura N, Ronald JA, Shuhendler A, Weber WA, Gilad AA, Müller C, Witney TH, Chen X. Spatiotemporal Concurrent PARP Inhibitor Sensitization based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy. Adv Healthc Mater. 2024 Apr 10:e2400908. Kang F, Niu M, Zhou Z, Zhang M, Xiong H, Zeng F, Wang J, Chen X. A DNA origami device spatially controls CD95 signalling to induce immune tolerance in rheumatoid arthritis Nat. Mater. (2024). DOI:10.1038/s41563-024-01865-5 Ling Li, Jue Yin, Wen Ma, Longguang Tang, Jianhua Zou, Linzi Yang, Ting Du, Yi Zhao, Lianhui Wang, Zhen Yang, Chunhai Fan, Jie Chao & Xiaoyuan Chen Carrier-Free Self-Assembly Nano-Sonosensitizers for Sonodynamic-Amplified Cuproptosis-Ferroptosis in Glioblastoma Therapy. Adv Sci (Weinh). 2024 Apr 6:e2402516. doi: 10.1002/advs.202402516 Zhu Y, Niu X, Ding C, Lin Y, Fang W, Yan L, Cheng J, Zou J, Tian Y, Huang W, Huang W, Pan Y, Wu T, Chen X, Kang D Clinical translation of a novel FAPI dimer [68Ga]Ga-LNC1013. Eur J Nucl Med Mol Imaging. 2024 Apr 2. doi: 10.1007/s00259-024-06703-z Tan Y, Li J, Zhao T, Zhou M, Liu K, Xiang S, Tang Y, Jakobsson V, Xu P, Chen X, Zhang J. Narrow Bandgap Schottky Heterojunction Sonosensitizer with High Electron-Hole Separation Boosted Sonodynamic Therapy in Bladder Cancer Adv Mater. 2024 Mar 28:e2401252 Li G, Wu S, Liu J, Wang K, Chen X, Liu H. Neutrophil Targeting Platform Reduces Neutrophil Extracellular Traps for Improved Traumatic Brain Injury and Stroke Theranostics. Adv Sci (Weinh). 2024 Mar 23:e2308719. doi: 10.1002/advs.202308719 Mu Q, Yao K, Syeda MZ, Wan J, Cheng Q, You Z, Sun R, Zhang Y, Zhang H, Lu Y, Luo Z, Li Y, Liu F, Liu H, Zou X, Zhu Y, Peng K, Huang C, Chen X, Tang L. Neutrophil Membrane-Camouflaged Polyprodrug Nanomedicine for Inflammation Suppression in Ischemic Stroke Therapy Adv Mater. 2024 Mar 22:e2311803. doi: 10.1002/adma.202311803 Zhao Y, Li Q, Niu J, Guo E, Zhao C, Zhang J, Liu X, Wang L, Rao L, Chen X, Yang K. Targeting Strategies for Site-Specific mRNA Delivery Bioconjug Chem. 2024 Mar 16. doi: 10.1021/acs.bioconjchem.4c00038 Di J, Huang P, Chen X Coassembly Nanomedicine Mediated by Intermolecular Interactions Between Methotrexate and Baricitinib for Improved Rheumatoid Arthritis Treatment. ACS Nano. 2024 Mar 4. doi: 10.1021/acsnano.3c12692 Xiong H, Zhang H, Qin Y, Ye J, Zeng F, Xie P, Shi C, Luo C, Xu W, Yu C, Zhou Z, Chen X Nanomedicines for an Enhanced Immunogenic Cell Death-Based In Situ Cancer Vaccination Response Acc Chem Res. 2024 Feb 28. doi: 10.1021/acs.accounts.3c00771 Zhao C, Wang C, Shan W, Wang Z, Chen X, Deng H. Self-Adjuvanting Polyguanidine Nanovaccines for Cancer Immunotherapy ACS Nano. 2024 Feb 26. doi: 10.1021/acsnano.3c11637 Zhang X, Wang K, Zhao Z, Shan X, Wang Y, Feng Z, Li B, Luo C, Chen X, Sun J Advancing nanotechnology for neoantigen-based cancer theranostics Chem Soc Rev. 2024 Feb 21. doi: 10.1039/d3cs00162h. Zou J, Zhang Y, Pan Y, Mao Z, Chen X Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03. Eur J Nucl Med Mol Imaging. 2024 Feb 20. doi: 10.1007/s00259-024-06634-9. Wen X, Wang R, Xu P, Shi M, Shang Q, Zeng X, Zeng X, Liu J, Wang X, Zhu Z, Guo Z, Chen X, Zhang J. A non-metal single atom nanozyme for cutting off the energy and reducing the power of tumors Angew Chem Int Ed Engl. 2024 Feb 15:e202319982. Cheng J, Li L, Jin D, Zhang Y, Yu W, Yu J, Zou J, Dai Y, Zhu Y, Liu M, Zhang M, Sun Y, Liu Y, Chen X Apoptotic Vesicular Metabolism Contributes to Organelle Assembly and Safeguards Liver Homeostasis and Regeneration Gastroenterology. 2024 Feb 9:S0016-5085(24)00136-7. Sui B, Wang R, Chen C, Kou X, Wu D, Fu Y, Lei F, Wang Y, Liu Y, Chen X, Xu H, Liu Y, Kang J, Liu H, Kin Kwok RT, Tang BZ, Yan H, Wang M, Xiang L, Yan X, Zhang X, Ma L, Shi S, Jin Y. AcousticRobots: Smart acoustically powered micro-/nanoswimmers for precise biomedical applications Adv Drug Deliv Rev. 2024 Feb 6;207:115201 Wu G, Xian W, You Q, Zhang J, Chen X Redox-responsive polymer micelles co-encapsulating immune checkpoint inhibitors and chemotherapeutic agents for glioblastoma therapy Nat Commun. 2024 Feb 6;15(1):1118 Zhang Z, Xu X, Du J, Chen X, Xue Y, Zhang J, Yang X, Chen X, Xie J, Ju S. pH/GSH dual responsive nanosystem for nitric oxide generation enhanced type I photodynamic therapy Bioact Mater. 2024 Jan 10;34:414-421. doi: 10.1016/j.bioactmat.2023.12.023. Zou J, Li Z, Zhu Y, Tao Y, You Q, Cao F, Wu Q, Wu M, Cheng J, Zhu J, Chen X Development and Applications of D-Amino Acid Derivatives-based Metabolic Labeling of Bacterial Peptidoglycan Angew Chem Int Ed Engl. 2024 Jan 29:e202319400 Zheng Y, Zhu X, Jiang M, Cao F, You Q, Chen X Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression Adv Mater. 2024 Jan 26:e2312275. doi: 10.1002/adma.202312275 Zhong D, Jin K, Wang R, Chen B, Zhang J, Ren C, Chen X, Lu J, Zhou M Lipodystrophy in methylmalonic acidemia associated with elevated FGF21 and abnormal methylmalonylation JCI Insight. 2024 Feb 22;9(4):e174097 Manoli I, Sysol JR, Head PE, Epping MW, Gavrilova O, Crocker MK, Sloan JL, Koutsoukos SA, Wang C, Ktena YP, Mendelson S, Pass AR, Zerfas PM, Hoffmann V, Vernon HJ, Fletcher LA, Reynolds JC, Tsokos MG, Stratakis CA, Voss SD, Chen KY, Brown RJ, Hamosh A, Berry GT, Chen XS, Yanovski JA, Venditti CP Mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision cancer gas therapy Acta Pharm Sin B. 2024 Jan;14(1):378-391 Yu H, Tiemuer A, Yao X, Zuo M, Wang HY, Liu Y, Chen X A comparison of [18F]AlF- and 68Ga-labeled dual targeting heterodimer FAPI-RGD in malignant tumor: preclinical evaluation and pilot clinical PET/CT imaging Eur J Nucl Med Mol Imaging. 2024 Jan 22. doi: 10.1007/s00259-023-06587-5 Liu N, Wan Q, Wu X, Zhao T, Jakobsson V, Yuan H, Chen X, Zhang J, Zhang W In Situ Reprogramming of Immune Cells Using Synthetic Nanomaterials Advanced materials (Deerfield Beach, Fla.), 2024, e2310168. Nie, S., Qin, Y., Ou, L., Chen, X., & Li, L. First-in-human validation of enzymolysis clearance strategy for decreasing renal radioactivity using modified [68Ga]Ga-HER2 Affibody. European journal of nuclear medicine and molecular imaging, 2024, 10.1007/s00259-023-06584-8. Zhang, M., Kang, F., Xing, T., Wang, J., Ma, T., Li, G., Quan, Z., Yang, W., Chen, X., & Wang, J. Synergistic Glutathione Depletion and STING Activation to Potentiate Dendritic Cell Maturation and Cancer Vaccine Efficacy Angewandte Chemie (International ed. in English), 2024, e202318530. Liu, J., Zhang, Y., Yang, B., Jia, Y., Liu, R. T., Ding, L., Shen, Z., & Chen, X. Long-term Nephrotoxicity after PRRT: Myth or Reality. Theranostics, 2024, 14(2), 451–459 Baum, R. P., Fan, X., Jakobsson, V., Yu, F., Schuchardt, C., Chen, X., & Zhang, J. Lower-grade gliomas surgery guided by GRPR-targeting PET/NIR dual-modality image probe: a prospective and single-arm clinical trial. Theranostics, 2024, 14(2), 819–829 Chen, L., Zhang, J., Chi, C., Che, W., Dong, G., Wang, J., Du, Y., Wang, R., Zhu, Z., Tian, J., Ji, N., Chen, X., & Li, D. LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism Theranostics, 2024, 14(1), 159–175 Wang, Y., Yin, Q., Yang, D., Jin, H., Yao, Y., Song, J., Liu, C., Nie, Y., Yin, H., Wang, W., Xu, B., Xue, L., Ji, X., Chen, X., & Zhao, H. Redox-Active Ferrocene Quencher-Based Supramolecular Nanomedicine for NIR-II Fluorescence-Monitored Chemodynamic Therapy Angewandte Chemie (International ed. in English), 2023, e202318155 Yu, M., Ye, Z., Liu, S., Zhu, Y., Niu, X., Wang, J., Ao, R., Huang, H., Cai, H., Liu, Y., Chen, X., & Lin, L. A Side-Effect-Free Interventional Therapy for Precisely Eliminating Unresectable Cancer Pain. ACS nano, 2023, 17(23), 23535–23544. Zhang, P., Yao, S., Tang, Y., Wan, S., Chen, X., & Ma, L. Rapid visualization of PD-L1 expression level in glioblastoma immune microenvironment via machine learning cascade-based Raman histopathology. Journal of advanced research, 2023, S2090-1232(23)00377-6. Zhou, Q. Q., Guo, J., Wang, Z., Li, J., Chen, M., Xu, Q., Zhu, L., Xu, Q., Wang, Q., Pan, H., Pan, J., Zhu, Y., Song, M., Liu, X., Wang, J., Zhang, Z., Zhang, L., Wang, Y., Cai, H., Chen, X., Lu, G. Single-arm trials for domestic oncology drug approvals in China Cancer biology & medicine, 2023, 20(11), 799–805. Zhang, H., Liu, S., Ge, C., Liu, X., Liu, Y., Yin, C., Li, Y., An, J., Yan, Z., & Chen, X. Fabrication of An Immunostimulatory Supramolecular Nanomedicine for Potent Cancer Chemoimmunotherapy JACS Au, 2023, 3(11), 3181–3193. Yu, X., Qi, S., Cao, F., Yang, K., Li, H., Peng, K., Liu, Z., Bai, B., Buljan, M., Chen, X., & Yu, G. Extended peptide receptor radionuclide therapy: evaluating nephrotoxicity and therapeutic effectiveness in neuroendocrine tumor patients receiving more than four treatment cycles European journal of nuclear medicine and molecular imaging, 2023, 10.1007/s00259-023-06544-2. Baum, R. P., Fan, X., Jakobsson, V., Schuchardt, C., Chen, X., Yu, F., & Zhang, J. Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023， e2306580. Li, Y., Guo, Y., Zhang, K., Zhu, R., Chen, X., Zhang, Z., & Yang, W. Ultrathin Clay Nanoparticles-Mediated Mutual Reinforcement of Ferroptosis and Cancer Immunotherapy. Advanced materials (Deerfield Beach, Fla.), 2023, e2309562. Liu, J., Zhan, J., Zhang, Y., Huang, L., Yang, J., Feng, J., Ding, L., Shen, Z., & Chen, X. Peroxynitrite-Scavenging Organosilica Nanomedicines for Light-Controllable NO Release and Precision On-Demand Glaucoma Therapy. ACS nano, 2023, 10.1021/acsnano.3c02685. Song, M., Li, L., Liu, J., Gao, Y., Li, M., Zhou, L., Qin, B., Xiang, A., Sun, X., Fan, W., Lei, Y., & Chen, X. Cellular Trafficking of Nanotechnology-Mediated mRNA Delivery Advanced materials (Deerfield Beach, Fla.), 2023, e2307822. Huang, P., Deng, H., Wang, C., Zhou, Y., & Chen, X. Stimuli-Responsive Nanoadjuvant Rejuvenates Robust Immune Responses to Sensitize Cancer Immunotherapy. ACS nano, 2023, 10.1021/acsnano.3c06233. Huang, R., Zhou, P., Chen, B., Zhu, Y., Chen, X., & Min, Y. Fibroblast Activation Protein-Targeted PET/CT with 18F-Fibroblast Activation Protein Inhibitor-74 for Evaluation of Gastrointestinal Cancer: Comparison with 18F-FDG PET/CT. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2023, jnumed.123.266329. Xu, W., Cai, J., Peng, T., Meng, T., Pang, Y., Sun, L., Wu, H., Zhang, J., Chen, X., & Chen, H. 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