个人简介
教育经历
2006.09—2010.07 信阳师范学院 生物技术 本科
2010.09—2013.07 江苏大学 生物化学与分子生物学 硕士
2013.09—2016.07 复旦大学 生物信息学 博士
工作经历
2016.11—2020.12 美国德克萨斯大学休斯顿健康科学中心 博士后
2021.02—至今 复旦大学 基础医学院 青年研究员
科研项目
2021-2023,上海市浦江人才,“遗传变异介导增强子RNA促进肿瘤发展的机制研究“,主持
研究领域
计算生物学与多组学:开发计算生物学方法鉴别疾病中转录及转录后调控、翻译及翻译后调控中多维度多层次的功能分子
基因调控与复杂疾病:识别疾病中关键的调控元件并探索其机制和潜在临床价值
近期论文
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Zhang, Zhao; Lee, Joo-Hyung; Ruan, Hang; Ye, Youqiong; Krakowiak, Joanna; Hu, Qingsong; Xiang, Yu; Gong, Jing; Zhou, Bingying; Wang, Li; Lin, Chunru; Diao, Lixia; Mills, Gordon B.; Li, Wenbo; Han, Leng ; Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer, Nature Communications, 2019, 10(4562)
Zhang, Zhao; Jing, Ji; Ye, Youqiong; Chen, Zhiao; Jing, Ying; Li, Shengli; Hong, Wei; Ruan, Hang; Liu, Yaoming; Hu, Qingsong; Wang, Jun; Li, Wenbo; Lin, Chunru; Diao, Lixia; Zhou, Yubin;Han, Leng ; Characterization of the dual functional effects of heat shock proteins (HSPs) in cancer hallmarks to aid development of HSP inhibitors, Genome Medicine, 2020, 12(101)
Zhang, Zhao; Hong, Wei; Ruan, Hang; Jing, Ying; Li, Shengli; Liu Yaoming; Wang, Jun; Li,Wenbo; Diao, Lixia; Han, Leng ; HeRA: an atlas of enhancer RNAs across human tissues, Nucleic acids research, 2021, 49(D1): 932-938
Zhang, Zhao; Luo, Mei; Li, Qiang; Liu, Yuan; Lussier, Charles; Zhang, Jian; Ye, Youqiong; Guo, An-Yuan; Han, Leng ; Genetic, Pharmacogenomic and Immune landscapes of enhancer RNAs across human cancers, Cancer Research, 2022, 82(5): 785-790
Jin, Weiwei; Jiang, Guanghui; Yang, Yanbo; Yang, Jianye; Yang, Wenqian; Wang, Dongyang; Niu, Xiaohui; Zhong, Rong; Zhang, Zhao; Gong, Jing ; Animal-eRNAdb: a comprehensive animal enhancer RNA database, Nucleic acids research, 2022, 50(D1): 46-53