周庆同 - 复旦大学 - 基础医学院

个人简介

教育经历 2005.09—2009.06 中国科学技术大学高分子化学专业本科生 2009.09—2015.06 中国科学技术大学高分子化学与物理专业博士研究生 2012.09—2014.09 美国哈佛大学化学与生物化学系联合培养博士研究生 2019.09—2019.12 比利时鲁汶大学癌症研究中心访问学者工作经历 2015.07—2018.09 上海科技大学iHuman研究所博士后研究员 2018.10—2020.06 上海科技大学iHuman研究所研究助理教授 2020.07—至今复旦大学基础医学院青年研究员

研究领域

G蛋白偶联受体的结构与功能研究重要蛋白靶标的药物筛选和设计研究

近期论文

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Zhou, Q.#, Xia, X.#, Luo, Z., Liang, H. *, and Shakhnovich, E. * (2015). Searching the Sequence Space for Potent Aptamers Using SELEX in Silico. J Chem Theory Comput 11, 5939-5946. Zhou, Q., Sun, X., Xia, X., Fan, Z., Luo, Z., Zhao, S., Shakhnovich, E. *, and Liang, H. * (2017). Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space. J Phys Chem Lett 8, 407-414. Song, G., Yang, D., Wang, Y., de Graaf, C., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., et al. (2017). Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature 546, 312-315. Zhou, Q. #, Yang, D. #, Wu, M., Guo, Y., Guo, W., Zhong, L., Cai, X., Dai, A., Jang, W., Shakhnovich, E.I., et al. (2019). Common activation mechanism of class A GPCRs. Elife 8, e50279. Tan, L. #, Zhou, Q. #, Yan, W., Sun, J., Kozikowski, A.P., Zhao, S., Huang, X.P.*, and Cheng, J.* (2020). Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands. J Med Chem 63, 4579-4602. Sun, W. #, Chen, L.N. #, Zhou, Q. #, Zhao, L.H., Yang, D., Zhang, H., Cong, Z., Shen, D.D., Zhao, F., Zhou, F., et al. (2020). A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Res 30, 1098-1108. Zhang, X. #, He, C. #, Wang, M. #, Zhou, Q. #, Yang, D. #, Zhu, Y. #, Feng, W., Zhang, H., Dai, A., Chu, X., et al. (2021). Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nat Chem Biol 17, 1230-1237. Zhao, F. #, Zhou, Q. #, Cong, Z. #, Hang, K. #, Zou, X. #, Zhang, C., Chen, Y., Dai, A., Liang, A., Ming, Q., et al. (2022). Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nat Commun 13, 1057. Cui, M. #, Zhou, Q.#*, Xu, Y., Weng, Y., Yao, D., Zhao, S., and Song, G.* (2022). Crystal structure of a constitutive active mutant of adenosine A2A receptor. IUCrJ 9. Cong, Z. #, Liang, Y.L. #, Zhou, Q. #, Darbalaei, S., Zhao, F., Feng, W., Zhao, L., Xu, H.E., Yang, D., and Wang, M.W. (2022). Structural perspective of class B1 GPCR signaling. Trends Pharmacol Sci 43, 321-334.