易志刚 - 复旦大学 - 基础医学院

个人简介

教育经历 1996-2000学士，青岛海洋大学 2000-2003硕士，中国海洋大学（原青岛海洋大学） 2003-2006博士，复旦大学工作经历 2014.1-今副研究员，复旦大学基础医学院病原生物系分子病毒学实验室 2009.3-2012.6 博士后，洛克菲勒大学 2006.7-2013.12 讲师，复旦大学基础医学院病原生物系分子病毒学实验室

研究领域

RNA病毒复制机制：以单正链RNA病毒如ZIKV, SARS-CoV-2等为对象，结合反向遗传学及生物化学研究病毒各种蛋白复合物的组装机制，以期找到新的抗病毒策略新型疫苗设计：利用反向遗传学，构建新型疫苗载体及新型疫苗新发病原鉴定及新型病毒培养模型：分离、鉴定新发及难培养病毒，建立其细胞培养模型

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Su J, Ma X, Zhang Y, Zou J, Yuan Z*, Yi Z*. NS5-independent ablation of STAT2 by Zika virus to antagonize interferon signaling. Emerg Microbes Infect. 2021 Dec;10(1):1609-1625 Zhang Y, Chen, S, Yuan Z*, Yi Z*. Bioorthogonal dissection of the replicase assembly of hepatitis C virus. Cell Chemical Biology. 2021 September 16, 28:1366–1378 (featured article) Zhang Y, Song W, Chen, S, Yuan Z*, Yi, Z*. A bacterial artificial chromosome (BAC)-vectored noninfectious replicon of SARS-CoV-2. Antiviral Res. 2021 Jan;185:104974 Zhang H, Song Z, Zou J, Feng Y, Zhang J, Ren L, Zhang X, Hu Y, Yuan Z*, Yi Z*. An infectious clone of enterovirus 71(EV71) that is capable of infecting neonatal immune competent mice without adaptive mutations. Emerg Microbes Infect. 2020, 9(1):427-438. Zhang Y, Zou J, Zhao, X, Yuan Z*, Yi, Z*. Hepatitis C virus NS5A inhibitor daclatasvir allosterically impairs NS4B-involved protein-protein interactions within the viral replicase and disrupts the replicase quaternary structure in a replicase assembly surrogate system. J Gen Virol. 2019;100(1):69-83 Zhang J, Zhang Y, Kang JY, Chen S, He Y, Han B, Liu MF, Lu L, Li L, Yi Z*, Chen L*. Potential transmission chains of variant B.1.1.7 and co-mutations of SARS-CoV-2. Cell Discov. 2021 Jun 15;7(1):44 Jia X, Hu L, Wu M, Ling Y, Wang W, Lu H, Yuan Z, Yi Z*, Zhang X*.A streamlined clinical metagenomic sequencing protocol for rapid pathogen identification. Sci Rep. 2021 Feb 23;11(1):4405 Yi Z#*, Ling Y#, Zhang X#, Chen J#, Hu K, Wang Y, Song W, Ying T, Zhang R, Lu H*, Yuan Z*. Functional mapping of B-cell linear epitopes of SARS-CoV-2 in COVID-19 convalescent population. Emerg Microbes Infect. 2020 Dec;9(1):1988-1996 Zhang X#, Tan Y#, Ling Y#, Lu G#, Liu F#, Yi Z#, Jia X, Wu M, Shi B, Xu S, Chen J, Wang W, Chen B, Jiang L, Yu S, Lu J, Wang J, Xu M, Yuan Z, Zhang Q, Zhang X, Zhao G, Wang S*, Chen S*, Lu H*. Viral and Host Factors Related to the Clinical Outcome of COVID-19. Nature. 2020, 583(7816): 437-440 Zhang Y, Zhao X, Zou J, Yuan Z*, Yi Z*. Dual role of the amphipathic helix of hepatitis C virus NS5A in the viral polyprotein cleavage and replicase assembly. Virology. 2019; 535: 283-296