个人简介
教育经历
1996.09-2000.07 复旦大学，药学院药物化学专业，学士
2001.09—2005.07 复旦大学，基础医学院生物化学与分子生物学系，硕士
2006.09—2010.07 复旦大学，基础医学院生物化学与分子生物学系，博士
工作经历
2000—2005 复旦大学，上海医学院生物化学与分子生物学系，助教
2006—2015 复旦大学，上海医学院生物化学与分子生物学系，讲师
2016—至今 复旦大学，上海医学院生物化学与分子生物学系，副教授
获得奖项
2007，上海市科学技术进步奖，三等奖，糖基转移酶对细胞生物学行为的调控（20072020）
近期论文
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Biyun Wang#, Yannan Zhao#, Yi Li#, Yingying Xu#, Yun Chen, Qiuyu Jiang, Dingjin Yao, Li Zhang, Xichun Hu*, Chaowei Fu*, Si Zhang*, She Chen*. A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients. Molecular Cancer. 2022; 21:22.
Wang S#, Cai J#, Zhang S, Dong M, Zhang L, Xu Y*, Shen B*, Chen S*. Loss of polarity protein Par3, via transcription factor Snail, promotes bladder cancer metastasis. Cancer Sci. 2021 Jul;112(7):2625-2641.
Yannan Zhao, Huitong Peng, Limiao Liang, Yi Li, Xichun Hu, Biyun Wang*, Yingying Xu*, She Chen*. Polarity protein Par3 sensitizes breast cancer to paclitaxel by promoting cell cycle arrest. Breast Cancer Res Treat. 2022 Feb;192(1):75-87.
Zhao Guang-Xi#, Xu Ying-Ying#, Weng Shu-Qiang#, Zhang Si, Chen Ying, Shen Xi-Zhong*, Dong Ling*, Chen She*. CAPS1 promotes colorectal cancer metastasis via Snail mediated epithelial mesenchymal transformation. Oncogene 2019. 38(23): 4574-4589.
Zhang Y#, Xu YY#, Yao CB, Li JT, Zhao XN, Yang HB, Zhang M, Yin M*, Chen J*, Lei QY*. Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone. Autophagy 2017, Mar 4;13(3):538-553.（
Yang HB#, Xu YY#*, Zhao XN, Zou SW*, Zhang Y, Zhang M, Li JT, Ren F, Wang LY and Lei QY*. Acetylation of MAT IIa represses tumour cell growth and is decreased in human hepatocellular cancer. Nature Communications 2015, Apr 30, 6:6973.
Wang J#, Zhu ZH#, Yang HB, Zhang Y, Zhao XN, Zhang M, Liu YB, Xu YY*，Lei QY. Cullin 3 targets methionine adenosyltransferase IIα for ubiquitylation-mediated degradation and regulates colorectal cancer cell proliferation. FEBS Journal 2016, 283(13):2390-402.
Xu YY, Guan DY, Yang M, Wang H, and Shen ZH*. All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism. Journal of Cellular Biochemistry 2010, 109, 468-477.
Xu YY, Lu Y, Fan KY, and Shen ZH*. Apoptosis induced by all-trans retinoic acid in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells is mediated through endoplasmic reticulum stress. Journal of Cellular Biochemistry 2007, 100, 773-782.
Fang H#, Huang W#, Xu YY#, Shen ZH, Wu CQ, Qiao SY, Xu Y, Yu L, Chen HL*. Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells. Cell Research 2006, 16, 82-92.
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