王作云 - 复旦大学 - 基础医学院

个人简介

教育经历 2002.09—2006.07 临沂大学生物科学专业（本科） 2006.09—2009.07 浙江理工大学生物化学与分子生物学专业（硕士） 2010.09—2013.07 中科院生物化学与细胞生物学研究所细胞生物学专业（博士）工作经历 2013.08—2017.07 中科院生物化学与细胞生物学研究所，博士后 2017.08—2021.02 中科院生物化学与细胞生物学研究所，助研及副研究员 2021.03—至今复旦大学基础医学院青年研究员，课题组组长，博士生导师获得奖项 2010年度中国生物化学与分子生物学学会青年科学家论坛奖 2014年度中国科学院上海生科院优秀青年人才奖 2020年度中国科学院上海生科院赛诺菲优秀青年人才奖 2021年度上海市细胞生物学学会优秀青年学者奖

研究领域

利用生化、分子与细胞生物学等研究手段，解析重要信号通路在细胞增殖、细胞分化、细胞凋亡过程中的功能及分子机制。利用小鼠的疾病以及肿瘤模型，结合人体临床样本分析，揭示Hippo等信号网络在疾病以及肿瘤发生中的功能及作用机理；同时利用细胞和小鼠疾病模型筛选抗肿瘤及免疫相关的小分子化合物。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jinlong Suo#, Xue Feng#, Jiayi Li, Jinghui Wang, Zuoyun Wang*, Lei Zhang*, Weiguo Zou*. VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcriptions. Science Advances, 2020 23; 6 (43): eaba4147. Wei Yu#, Xueyan Ma#, Jinjin Xu, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang*, Bin Zhou* and Lei Zhang*. VGLL4 plays a critical role in heart valve development and homeostasis. PLoS Genetics, 2019, 15(2): e1007977. Xue Feng#, Zuoyun Wang#, Fei Wang#, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He,Wenxiang Zhang, Sheng Li, Wenjun Yang, Lili Han, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu*, and Lei Zhang*. Dual function of VGLL4 in muscle regeneration. EMBO Journal, 2019, 38(17):e101051. Zuoyun Wang, Zhaoyuan Fang, Gaobin Chen, Bo Liu, Jinjin Xu, Fei Li, Fuming Li, Hongyan Liu, Haoen Zhang, Yihua Sun, Gang Tian, Haiquan Chen, Guoliang Xu, Lei Zhang, Liang Hu, Hongbin Ji *. CBX4 exerts oncogenic properties in lung cancer through Wnt signalling pathway. Neoplasia, 2021; 23 (2):222-233. Zuoyun Wang #, Yihua Sun#, Bin Gao#, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-Yuan Liu, William Pao, Yun Zhao*, Haiquan Chen*, Hongbin Ji*. Two co-existed germline mutations P53V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome. Cancer Letters. 2014, 342 (1):36-42. Zuoyun Wang#, Yan Feng#, Nabeel Bardessy, Kwok-kin Wong, Xin-Yuan Liu*, Hongbin Ji*. Temporal dissection of K-rasG12D Mutant in vitro and in vivo using a regulatable K-rasG12D mouse allele. PLoS One. 2012, 7, e37308. Jingqiang Wang # , Chunye Liu # , Lingli He #, Zhiyao Xie, Lanyue Bai, Wentao Yu, Zuoyun Wang, Yi Lu, Dong Gao, Junfen Fu*, Lei Zhang*, Yi Arial Zeng*. Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair. eLife, 2022,11:e75449. Xue Feng#, Tiantian Lu#, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng*, Wei Tian*, Lei Zhang* The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice. Hepatology, 2020, 71(6):1988-2004 Lingli He, Liang Yuan, Yang Sun, Pingyang Wang, Hailin Zhang, Xue Feng, Zuoyun Wang, Wenxiang Zhang, Chuanyu Yang, Yi Arial Zeng, Yun Zhao, Ceshi Chen*, Lei Zhang* Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression. Cancer Research, 2019, 79(17):4399-4411. Wenjing Zhang#, Yijun Gao#, Peixue Li#, Zhubing Shi, Tong Guo, Fei Li, Xiangkun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Fuming Li, Haiquan Chen, Zhaocai Zhou*, Lei Zhang*, Hongbin Ji*. VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex. Cell Research, 2014, 24(3):331-43.