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个人简介

教育经历 1978.02—1982.12 上海第一医学院医学专业本科生 1986.10—1989.11 英国剑桥大学生理学博士研究生 工作经历 1983.01—1984.06 上海市第六人民医院骨科住院医师 1984.07—1985.09 美国加州大学洛杉矶分校医学院访问学者 1985.10—1986.09 英国剑桥动物生理研究所访问学者 1989.12—1990.05 英国剑桥大学医学院资深研究助理 1990.06—1992.07 美国Amylin医药公司研究员 1992.08—1996.07 美国Ligand医药公司研究主管 1996.08—1997.12 美国GC生物技术有限公司董事 1998.01—2000.06 上海基康生物技术有限公司董事长兼总经理 2000.07—2001.11 美国安塞尔医药公司副董事长 2001.12—2021.12 中国科学院上海药物研究所研究员(二级) 2003.08—2021.12 国家新药筛选中心主任 2012.01—2021.12 国家化合物样品库主任 2015.01—至今 上海科技大学生命科学与技术学院特聘教授 2015.10—2021.01 复旦大学药学院院长 2022.04—至今:日本东京大学理学院化学系客座教授 获得奖项 2002年获得上海市“白玉兰纪念奖” 2002年获得上海市科学技术进步一等奖 2003年获得国家科学技术进步二等奖 2012年获得上海市“白玉兰荣誉奖” 2012年获评全国优秀科技工作者 2014年获得浦东新区科技进步一等奖 2020年获得上海市自然科学一等奖

研究领域

新药筛选和基础药理学研究

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Fai Yiu Siu, Min He, Chris de Graaf, Gye Won Han, Dehua Yang, Zhiyun Zhang, Caihong Zhou, Qingping Xu, Daniel Wacker, Jeremiah S. Joseph, Wei Liu, Jesper Lau, Vadim Cherezov, Vsevolod Katritch, Ming-Wei Wang* and Raymond C. Stevens* (2013). Structure of the human glucagon class B G-protein-coupled receptor. Nature, 499, 444–449. Haonan Zhang#, Anna Qiao#, Dehua Yang#, Linlin Yang#, Antao Dai, Chris de Graaf, Steffen Reedtz-Runge, Venkatasubramanian Dharmarajan, Hui Zhang, Gye Won Han, Thomas D. Grant, Raymond G. Sierra, Uwe Weierstall, Garrett Nelson, Wei Liu, Yanhong Wu, Limin Ma, Xiaoqing Cai, Guangyao Lin, Xiaoai Wu, Zhi Geng, Yuhui Dong, Gaojie Song, Patrick R. Griffin, Jesper Lau, Vadim Cherezov, Huaiyu Yang, Michael A. Hanson, Raymond C. Stevens, Qiang Zhao, Hualiang Jiang*, Ming-Wei Wang* and Beili Wu* (2017). Structure of the full-length glucagon class B G-protein-coupled receptor. Nature, 546, 259–264. Gaojie Song, Dehua Yang, Yuxia Wang, Chris de Graaf, Qingtong Zhou, Shanshan Jiang, Kaiwen Liu, Xiaoqing Cai, Antao Dai, Guangyao Lin, Dongsheng Liu, Fan Wu, Yiran Wu, Suwen Zhao, Li Ye, Gye Won Han, Jesper Lau, Beili Wu, Michael A. Hanson, Zhi-Jie Liu*, Ming-Wei Wang* and Raymond C. Stevens* (2017). Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature, 546, 312–315. Li-Hua Zhao#,, Shanshan Ma#,, Ieva Sutkeviciute#,, Dan-Dan Shen#,, X. Edward Zhou, Parker W. de Waal, Chen-Yao Li, Yanyong Kang, Lisa J. Clark, Frederic G. Jean-Alphonse, Alex D. White, Dehua Yang, Antao Dai, Xiaoqing Cai, Jian Chen, Cong Li, Yi Jiang, Tomoyuki Watanabe, Thomas J. Gardella, Karsten Melcher, Ming-Wei Wang*, Jean-Pierre Vilardaga*, H. Eric Xu* and Yan Zhang* (2019). Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 148-153. Fulai Zhou#, Huibing Zhang#, Zhaotong Cong#, Li-Hua Zhao#, Qingtong Zhou#, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang*, H. Eric Xu*, Yan Zhang* and Ming-Wei Wang* (2020). Structural basis for activation of the growth hormone-releasing hormone receptor. Nature Communications, 11, 5205. Wen Sun#, Li-Nan Chen#, Qingtong Zhou#, Li-Hua Zhao#, Dehua Yang#, Huibing Zhang, Zhaotong Cong, Dan-Dan Shen, Fenghui Zhao, Fulai Zhou, Xiaoqing Cai, Yan Chen, Yan Zhou, Sarina Gadgaard, Wijnand J. C. van der Velden, Suwen Zhao, Yi Jiang, Mette M Rosenkilde, H. Eric Xu*, Yan Zhang* and Ming-Wei Wang* (2020). A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Research 30, 1098-1108. Shuling Lin#, Shuo Han#, Xiaoqing Cai#, Qiuxiang Tan, Kexiu Zhou, Dejian Wang, Xinwei Wang, Juan Du, Cuiying Yi, Xiaojing Chu, Antao Dai, Yan Zhou, Yan Chen, Yu Zhou, Hong Liu, Jianfeng Liu, Dehua Yang, Ming-Wei Wang*, Qiang Zhao* and Beili Wu* (2021). Structures of Gi-bound metabotropic glutamate receptors mGluR2 and mGluR4. Nature, 594, 583-588. Zhaotong Cong#, Li-Nan Chen#, Honglei Ma#, Qingtong Zhou#, Xinyu Zou, Chenyu Ye, Antao Dai, Qing Liu, Wei Huang, Xianqiang Sun, Xi Wang, Peiyu Xu, Lihua Zhao, Tian Xia, Wenge Zhong, Dehua Yang*, H. Eric Xu*, Yan Zhang* and Ming-Wei Wang* (2021). Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nature Communications, 12, 3763. Xi Wang#, Xi Cheng#, Lihua Zhao#, Yuzhe Wang, Chenyu Ye, Xinyu Zou, Antao Dai, Zhaotong Cong, Jian Chen, Qingtong Zhou, Tian Xia, Hualiang Jiang, H. Eric Xu*, Dehua Yang* and Ming-Wei Wang* (2021). Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2. Proc. Natl. Acad. Sci. USA, 118, 32 (e2101279118). Zhaotong Cong#, Fulai Zhou#, Chao Zhang#, Xinyu Zou#, Huibing Zhang, Yuzhe Wang, Qingtong Zhou, Xiaoqing Cai, Qiaofeng Liu, Jie Li, Lijun Shao, Chunyou Mao, Xi Wang, Jihong Wu, Tian Xia, Li-hua Zhao, Hualiang Jiang, H. Eric Xu*, Xi Cheng*, Dehua Yang* and Ming-Wei Wang* (2021). Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc. Natl. Acad. Sci. USA, 118, 40 (e2106606118).

学术兼职

上海浦东新区工程师协会理事长 Biochemical Journal(英国)副主编 《中国药理学报》副主编 Trends in Pharmacological Sciences(美国)编委 ACS Pharmacology and Translational Science(美国)编委

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