王立华 - 复旦大学 - 基础医学院

个人简介

教育经历 2006.09-2010.10 潍坊学院本科 2010.09-2017.03 中国科学技术大学博士工作经历 2017.05-2020.12 上海交通大学医学院博士后研究员 2021.1—至今复旦大学基础医学院青年副研究员获得奖项 2017年获中国科学院天然免疫与慢性疾病重点实验室优秀研究论文奖 2016年获安徽省普通高等学校品学兼优毕业生与中国科学技术大学优秀毕业生荣誉称号 2013年获中国科学技术大学优秀学生干部荣誉称号

研究领域

肿瘤细胞中物质能量代谢与细胞器重塑的作用脂类代谢在细胞命运调控中的作用与机制

近期论文

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Fatty acid synthesis is critical for stem cell pluripotency via regulating mitochondrial fission, EMBO J., 2017. 36(10): p. 1330-1347, Lihua Wang#, Tong Zhang, Lin Wang, Yongping Cai, Xiuying Zhong, Xiaoping He, Lan Hu, Shengya Tian, Mian Wu, Lijian Hui, Huafeng Zhang*and Ping Gao*（IF=11.598） MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2, Journal of Experimental & Clinical Cancer Research, 2019 Dec 19;38(1), Yi Ding#, Jie Yang#, Yawen Ma, Tengteng Yao, Xingyu Chen, Shengfang Ge*, Lihua Wang* and Xianqun Fan*（IF=11.161） Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells, Cell Metabolism 29, 1–14 March 5, 2019, Xiuying Zhong#, Peng Cui, Yongping Cai, Lihua Wang, Xiaoping He, Peipei, Lu Kangyang, Yan Ronghui, Zhang Ying, Pan Xin, Zhao Xiaoyang, Li Wei, Huafeng Zhang*, Qi Zhou* & Ping Gao*（IF=27.287） LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction, Cancer Letter, 2021 Mar 04;506, Yawen Ma #, Lihua Wang #,Fanglin He#, Jie Yang, Yi Ding, Shengfang Ge , Xianqun Fan,Yixiong Zhou, Xiaofang Xu, Renbing Jia * （IF=8.679） Sperm-Specific Glycolysis Enzyme Glyceraldehyde-3- Phosphate Dehydrogenase Regulated by Transcription Factor SOX10 to Promote Uveal Melanoma Tumorigenesis, Frontiers Cell and Developmental Biology, 2021;9 10.3389/ fcell. 2021. 610683，Xia Ding#, Lihua Wang#, Mingjiao Chen#, Yue Wu, Ge Shengfang, Jin Li*, Xianqun Fan*, Ming Lin*（IF=6.684） The role of mitochondrial dynamics in human cancers, American Journal of Cancer Research, Am J Cancer Res 2020;10(5):1278-1293, Yawen Ma#, Wang Lihua*, Jia Renbing*（IF=6.161） Role of de novo cholesterol synthesis enzymes in cancer, Journal of Cancer, 2020; 11(7): 1761-1767, Yang Jie#, Wang Lihua*, Jia Renbing*（IF=4.207） Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications, Life Science Alliance, (2019), DOI 10.26508/lsa.201900413, Shengya Tian, Junru Feng, Yang Cao,…, Lihua Wang, Huafeng Zhang, Xiuying Zhong, Ping Gao et al（IF=4.591） Targeting secreted cytokine BMP9 gates the attenuation of hepatic fibrosis, BBA-molecular basis of disease, Molecular Basis of Disease, (2018),Li Peng, Li Yongyun, Zhu Liqi, Yang Zhi, He Jie, Wang Lihua,…, Fan Xianqun, Ge Shengfang, Jia Renbing, Zhang He et al（IF=5.187） CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis , EMBO Reports, 2017.05, 18(5): 809~825, Zhong Xiuying, Tian Shengya,…, Wang Lihua, Song Libing, Zhang Huafeng, Pan Xin, Li Ailing, Gao Ping et al（IF=8.807）