李倩 - 复旦大学 - 基础医学院

个人简介

教育经历 2003.09—2008.07 郑州大学河南医学院本科 2008.09—2011.07 上海交通大学眼科学硕士 2012.07—2020.03 瑞典卡罗林斯卡医学院博士工作经历 2020.03—2021.03 瑞典卡罗林斯卡医学院博士后 2022.01—至今复旦大学基础医学院青年研究员

研究领域

侧重于将临床数据与人体脂肪组织实验室研究相结合的方式，探索肥胖和代谢失衡发展过程中的脂肪组织细胞学改变，与全身代谢稳态的关联，以及引起代谢失衡的机制通过探索临床用药及手术治疗等干预手段对脂肪组织的功能影响，开发靶向性逆转肥胖和代谢紊乱的新治疗方法

近期论文

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Qian Li*, Carolina E Hagberg*, Helena Silva Cascales … Anders Thorell, Kirsty L Spalding. Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce. Nature Medicine. 2021 Nov;27(11):1941-1953. Qian Li, Kirsty Spalding. Profiling hypertrophic adipocytes in humans, from transcriptomics to diagnostics. EBioMedicine, 2022 Jul;81:104105. Qian Li, Kirsty Spalding. The regulation of adipocyte growth in white adipose tissue. Fontiers of cell and development biology, 2022, Nov 22;10:1003219. Jesper Bäckdahl, Lovisa Franze´n, Lucas Massier, Qian Li… Mikael Rydén, Patrik L Ståhl, Niklas Mejhert. Spatial mapping reveals human adipocyte subpopulations with distinct sensitivities to insulin. Cell Metabolism. 2021 Nov 2;33(11):2301. Smith U, Li Q, Rydén M, Spalding KL. Cellular senescence and its role in white adipose tissue. Int J Obes (Lond). 2021 May;45(5):934-943. Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Spalding KL, Boucher J. Mature human white adipocytes cultured under membranes maintain identity, function, and can transdifferentiate into brown-like adipocytes. Cell Reports. 2019 Apr 2;27(1):213-225 Hagberg CE, Li Q, Kutschke M, Bhowmick D, Kiss E, Shabalina IG, Harms MJ, Shilkova O, Kozina V, Nedergaard J, Boucher J, Thorell A, Spalding KL. Flow cytometry of mouse and human adipocytes for the analysis of browning and cellular heterogeneity. Cell Reports. 2018 Sep 4;24(10):2746-2756. Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, … Arner P, Rydén M. Transforming growth factor-β3 regulates adipocyte number in subcutaneous white adipose tissue. Cell Reports, 2018 Oct; 25(3):551-560.