吕雷 - 复旦大学 - 基础医学院

个人简介

教育经历 2000.09-2004.07 复旦大学生命科学学院学士 2004.09-2007.07 复旦大学生命科学学院硕士 2007.09-2010.07 复旦大学生物医学研究院博士工作经历 2010.08-2012.06 复旦大学基础医学院博士后 2012.07-2013.03 上海交通大学医学院附属新华医院心胸外科临床PI 2013.03-2017.06 美国北卡罗莱纳大学教堂山分校Lineberger肿瘤中心博士后 2017.06-至今复旦大学基础医学院研究员获得奖项 2018，上海市自然科学奖一等奖（第二完成人） 2018，国家青年特聘专家，组织部 2014，教育部自然科学奖二等奖（第二完成人） 2013，上海市青年科技启明星 2013，上海市优秀博士论文

研究领域

肿瘤代谢调控机制研究代谢与表观遗传互作研究肿瘤免疫调控机制及转化医学研究

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Lei Lv, Dong Li, Di Zhao, Ruiting Lin, Yajing Chu, Heng Zhang, Zhengyu Zha, Ying Liu, Zi Li, Yanping Xu, Gang Wang, Yiran Huang, Yue Xiong, Kun-Liang Guan, Qun-Ying Lei*. Acetylation targets the M2 isoform of pyruvate kinase for degradation through chaperone-mediated autophagy and promotes tumor growth. Molecular Cell. 2011;42(6):719-30. Lei Lv#, Yan-Ping Xu#, Di Zhao, Fu-Long Li, Wei Wang, Naoya Sasaki, Ying Jiang, Xin Zhou, Ting-Ting Li, Kun-Liang Guan*, Qun-Ying Lei* and Yue Xiong*. Mitogenic and oncogenic stimulation of K433 acetylation promotes PKM2 protein kinase activity and nuclear localization. Molecular Cell. 2013;52(3):340-52. Tadashi Nakagawa#, Lei Lv#, Makiko NaKagawa, Yanbao Yu, Chao Yu, Ana C.D'Alessio, Keiko Nakayama, Heng-Yu Fan, Xian Chen and Yue Xiong*. CRL4VprBP E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases. Molecular Cell. 2015;57(2):247-60. Lei Lv#, Qi Wang#, Yanping Xu#, Li-chung Tsao#, Tadashi Nakagawa, Haitao Guo, Lishan Su* and Yue Xiong*. Vpr targets TET2 for degradation by CRL4VprBP E3 ligase to sustain IL-6 expression and enhance HIV-1 replication. Molecular Cell. 2018;70(5):961-970. Yan-ping Xu#, Lei Lv#, Ying Liu#, Matthew D. Smith, Wen-Cai Li, Xian-ming Tan, Meng Cheng, Zhijun Li, Michael Bovino, Jeffrey Aubé, and Yue Xiong*. Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy. Journal of Clinical Investigation. Journal of Clinical Investigation. 2019;129(10):4316–4331. Ruonan Zhang, Yajing Yang, Wenjing Dong, Mingen Lin, Jing He, Xinchao Zhang, Tongguan Tian, Yunlong Yang, Kun Chen, Qun-Ying Lei, Song Zhang*, Yanping Xu*, Lei Lv*. D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1. Proceedings of the National Academy of Sciences of the United States of America. 2022;119(8):e2114851119; . Xinchao Zhang, Shuyan Li, Jing He, Yun-jie Jin, Ruonan Zhang, Wenjing Dong, Mingen Lin, Yajing Yang, Tongguan Tian, Yuefan Zhou, Yixin Xu, Qun-Ying Lei, Jing Zhang, Qing Zhang, Yanping Xu*, Lei Lv*. TET2 suppresses VHL-deficiency-driven clear cell renal cell carcinoma by targeting HIF signaling. Cancer Research. 2022;canres. 3013.2021. doi: 10.1158/0008-5472.CAN-21-3013.

学术兼职

2020-至今中国细胞生物学学会细胞代谢分会委员 2020-至今中国细胞生物学学会科普工作委员会委员