刘晶 - 复旦大学 - 基础医学院

个人简介

教育经历 1992.09—1996.06 南开大学分子生物学专业本科生 1996.09—2002.04 中国科学院上海生命科学研究院生物化学与细胞生物学研究所生物化学与分子生物学专业博士研究生工作经历 2002.04—2007.09 中国科学院上海生命科学研究院生物化学与细胞生物学研究所助理研究员 2007.09—2014.12 复旦大学生物医学研究院/基础医学院病原生物学系助理研究员 2014.12—至今复旦大学生物医学研究院/基础医学院病原生物学系副教授科研项目 2019，国家自然科学基金面上项目，“基于白介素21的细胞治疗促进乙型肝炎病毒持续性感染清除的机制及应用研究”，主持 2017，国家重点研发计划，“重要疫源动物微生物群落与未新病原的致病耐药性和适应进化研究”，子课题负责人 2017，国家自然科学基金面上项目，“决定肝细胞对乙型肝炎病毒易感性的关键分子研究”，主持 2012，国家自然科学基金面上项目，“Prox1蛋白抑制乙型肝炎病毒的分子机制及应用研究”，主持

研究领域

乙型肝炎病毒（HBV）分子生物学、分子病毒学、免疫学；HBV动物模型及治疗药物研发；重组HBV载体系统及其应用病毒生物信息学；远古病毒与新发/新现病毒研究肝脏基因表达调控；肝癌及其它肿瘤发生发展机制及药物研究

近期论文

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Shen, Z.#*, Wu, J.#, Gao, Z. #, Zhang, S., Chen, J., He, J., Guo, Y., Deng, Q., Xie, Y.*, Liu, J. #*, & Zhang, J.* (2022). High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein. Nucleic Acids Res. 2022;50(4):2157–2171 2.Shen, Z.#, Wu, J.#, Gao, Z.#, Wang, J., Zhu, H., Mao, R., Wang, X., Zhang, J.*, Xie, Y.*, Liu, J*. Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection. Theranostics 2020; 10(12): 5600-5612 Gu, C.#, Ming, L.#, Fang, Y., Liu, X., Zhang, J., Zelinskyy, G., Deng, Q., Liu, J*., Xie, Y*. Restriction of exogenous DNA expression by SAMHD1. Sci Bull 2020; 65(7):573-586 Shen, Z.#, Liu, J.#*, Wu, J.#, Zhu, Y., Li, G., Wang, J., Luo, M., Deng, Q., Zhang, J.*, Xie, Y*. IL-21-based therapies induce clearance of hepatitis B virus persistence in mouse models. Theranostics 2019; 9(13): 3798-3811. Shen, Z.#, Yang, H.#, Yang, S.#, Wang, W., Cui, X., Zhou, X., Liu, W., Pan, S., Liu, Y., Zhang, J., Zhang, J.*, Xie, Y.*, Liu, J*. Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance. Nat Commun 2017; 8: 2119. Liu, Y., Zhang, Y., Wang, S., Dong, Q. Z., Shen, Z., Wang, W., Tao, S., Gu, C., Liu, J.*, Xie, Y.*, Qin, L. X*. Prospero-related homeobox 1 drives angiogenesis of hepatocellular carcinoma through selectively activating IL-8 expression. Hepatology 2017; 66(6):1894-1909 Han, Y.#, Gu, L.#, Liu, J.#, Li, X.#, Wang, M., Gong, Q., Yu, D., Yang, Z., Zhang, D., Yang, H., Shen, Z., Zhu, H., Xie, Y.*, Zhang, X*. Association of Mutations in Toll-like Receptor 2 Signaling Genes With Fulminant Form of Hepatitis B-Related Acute Liver Failure. J Infect Dis 2017;215(8):1221-1230. Bai, W.#, Cui, X.#, Chen, R., Tao, S., Hong, R., Zhang, J., Zhang, J., Wang, Y., Xie, Y.*, Liu, J.*. Re-Designed Recombinant Hepatitis B Virus Vectors Enable Efficient Delivery of Versatile Cargo Genes to Hepatocytes with Improved Safety. Viruses 2016;8(5) doi: 10.3390/v8050129 Liu, Y., Ye, X., Zhang, J.B., Ouyang, H., Shen, Z., Wu, Y., Wang, W., Wu, J., Tao, S., Yang, X., Qiao, K., Zhang, J., Liu, J.*, Fu, Q.*, Xie, Y*. PROX1 promotes hepatocellular carcinoma proliferation and sorafenib resistance by enhancing beta-catenin expression and nuclear translocation. Oncogene 2015;34(44):5524-5535 Zhao, X., Wu, Y., Duan, J., Ma, Y., Shen, Z., Wei, L., Cui, X., Zhang, J., Xie, Y.*, Liu, J*. Quantitative Proteomic Analysis of Exosome Protein Content Changes Induced by Hepatitis B Virus in Huh-7 Cells Using SILAC Labeling and LC-MS/MS. J Proteome Res 2014;13(12):5391-5402