李慧艳 - 复旦大学 - 基础医学院

研究领域

肿瘤的免疫调控与免疫治疗生物节律的调控机制神经免疫如何调控机体抗病毒感染

近期论文

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Hu HB, Song ZQ, Song GP, Li S, Tu HQ, Wu M, Zhang YC, Yuan JF, Li TT, Li PY, Xu YL, Shen XL, Han QY, Li AL, Zhou T, Chun J, Zhang XM, Li HY*. LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis. Nat Commun. 2021 Jan 28;12(1):662. Zhang YC, Bai YF, Yuan JF, Shen XL, Xu YL, Jian XX, Li S, Song ZQ, Hu HB, Li PY, Tu HQ, Han QY, Wang N, Li AL, Zhang XM, Wu M, Zhou T, Li HY*. CEP55 promotes cilia disassembly through stabilizing Aurora A kinase. J Cell Biol. 2021 Feb 1;220(2):e202003149. Wang G, Hu HB, Chang Y, Huang Y, Song ZQ, Zhou SB, Chen L, Zhang YC, Wu M, Tu HQ, Yuan JF, Wang N, Pan X, Li AL, Zhou T, Zhang XM, He K, Li HY*. Rab7 regulates primary cilia disassembly through cilia excision. J Cell Biol. 2019 Dec 2;218(12):4030-4041. Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H*. LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores. Nat Commun. 2019 Jan 17;10(1):273. Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY*. Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis. Nat Commun. 2018 Dec 11;9(1):5277. Gao YF, Li T, Chang Y, Wang YB, Zhang WN, Li WH, He K, Mu R, Zhen C, Man JH, Pan X, Li T, Chen L, Yu M, Liang B, Chen Y, Xia Q, Zhou T, Gong WL, Li AL, Li HY*, Zhang XM*. Cdk1-phosphorylated CUEDC2 promotes spindle checkpoint inactivation and chromosomal instability. Nat Cell Biol. 2011 Jul 10;13(8):924-33. Man JH, Liang B, Gu YX, Zhou T, Li AL, Li T, Jin BF, Bai B, Zhang HY, Zhang WN, Li WH, Gong WL, Li HY*, Zhang XM*. Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. J Clin Invest. 2010 Aug;120(8):2829-41. Li HY#, Liu H, Wang CH, Zhang JY, Man JH, Gao YF, Zhang PJ, Li WH, Zhao J, Pan X, Zhou T, Gong WL, Li AL, Zhang XM. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1. Nat Immunol. 2008 May;9(5):533-41. Zhang WN, Zhou J, Zhou T, Li AL, Wang N, Xu JJ, Chang Y, Man JH, Pan X, Li T, Li WH, Mu R, Liang B, Chen L, Jin BF, Xia Q, Gong WL, Zhang XM, Wang L, Li HY*. Phosphorylation-triggered CUEDC2 degradation promotes UV-induced G1 arrest through APC/C(Cdh1) regulation. Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11017-22. Wang YB, Tan B, Mu R, Chang Y, Wu M, Tu HQ, Zhang YC, Guo SS, Qin XH, Li T, Li WH, Li AL, Zhang XM, Li HY*. Ubiquitin-associated domain-containing ubiquitin regulatory X (UBX) protein UBXN1 is a negative regulator of nuclear factor κB (NF-κB) signaling. J Biol Chem. 2015 Apr 17;290(16):10395-405.

学术兼职

2010-至今国家自然科学基金委员会评审专家