龙钢 - 复旦大学 - 基础医学院

个人简介

教育经历 1995.09—1999.07 南昌大学生物工程专业本科生 1999.09—2002.07 中国科学院武汉病毒研究所病毒学专业硕士研究生 2002.09—2007.03 荷兰瓦格宁根大学病毒学专业博士研究生工作经历 2002.07—2007.07 中国科学院武汉病毒研究所助理研究员 2007.07—2012.12 德国海德堡大学医学院博士后 2013.01—2022.02 中国科学院上海巴斯德研究所研究员，课题组长 2022.03至今复旦大学基础医学院病原生物系研究员，课题组长获得奖项 2007，欧盟玛丽居里奖学金

研究领域

肝炎、虫媒等医学病毒的感染和致病机制及病毒感染活细胞示踪体系研发胞外囊泡生物发生和物质分选机制

近期论文

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Chen H＊, Zhang X, Yang R, Wang G…. Long G＃, Xu C＃. An intein-split transactivator for intersectional neural imaging and optogenetic manipulation. Nature Communications, 2022 revision submitted. Jiang W＊, Ma P, Deng L, Liu Z, Wang X, Liu X, Long G＃. Hepatitis A virus structural protein pX interacts with ALIX and promotes the secretion of virions and foreign proteins through exosome-like vesicles. Journal of Extracellular Vesicles 2020 Jan 22;9(1):1716513. Deng L＊, Jiang W, Wang X, Merz A, Hiet MS, Chen Y, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G＃. Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes. J Hepatol. 2019 Mar 15 (19)30147-3. Bian WX＊, Xie Y, Wang XN, Xu GH, Fu BS, Li S, Long G, Zhou X, Zhang XL＃. Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication.Nucleic Acids Res. 2019 Jan 10;47(1):56-68. Zhao F＊, Xu Y, Lavillette D, Zhong J, Zou G, Long G＃. Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone.Sci Rep. 2018 Jul 12;8(1):10491. Jiang W＊, Muhammad F, Ma P, Liu X, Long G＃.Sofosbuvir inhibits hepatitis A virus replication in vitro assessed by a cell-based fluorescent reporter system.Antiviral Res. 2018 Jun;154:51-57. doi: 10.1016 Levander S＊, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M＃. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model. Gut. 2018 Aug; 67(8):1525-1535. Zhao F＊, Zhao T, Deng L, Lv D, Zhang X, Pan X, Xu J, Long G＃. Visualizing the Essential Role of Complete Virion Assembly Machinery in Efficient Hepatitis C Virus Cell-to-Cell Transmission by a Viral Infection-Activated Split-Intein-Mediated Reporter System. J Virol. 2017 Jan 3; 91(2):1720-16. Yang Z＊, Wang X, Chi X, Zhao F, Guo J, Ma P, Zhong J, Niu J, Pan X, Long G＃. Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection. J Virol. 2016 Oct 14; 90(21):9632-9643. Long G＊, Hiet MS, Windisch MP, Lee JY, Lohmann V, Bartenschlager R＊. 2011. Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology, 141(3):1057-66.

学术兼职

2017-今中华医学会病毒学分会，青年委员 2019-今中国研究型医院学会胞外囊泡学会，委员 2018-2021 全脑神经联接图谱与克隆猴模型计划骨干 2019-2020 清华大学结构生物学高精尖创新中心合作研究员