李蓓 - 复旦大学 - 基础医学院

个人简介

教育经历 2011.04 — 2017.02瑞士苏黎世大学，分子生物学系，博士 2005.09 — 2008.03同济大学，生物化学与分子生物学系，硕士 2001.09 — 2005.06扬州大学，生物技术系，本科工作经历 2022.02 — 至今复旦大学基础医学院，中西医结合学系，青年副研究员 2019.10 — 2022.01复旦大学基础医学院，神经生物学系，博士后 2010.01 — 2011.03瑞士苏黎世大学医院，神经病理学研究所，研究助理科研项目 2022，国家自然科学基金青年基金项目，国家自然科学基金委员会，主持 2021，中国博士后科学基金面上项目资助一等，中国博士后科学基金会，主持

研究领域

神经退行性疾病的发病机制和诊治方法全自动高通量筛选在疾病研究和药物开发中的应用

近期论文

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Bei Li, Meiling Chen, Adriano Aguzzi, Caihong Zhu. The role of macrophage scavenger receptor 1 (Msr1) in prion pathogenesis. Journal of Molecular Medicine (Berlin, Germany). 2021; 99(6), 877–887. Bei Li#, Meiling Chen#, Caihong Zhu.Neuroinflammation in Prion Disease. International Journal of Molecular Sciences. 2021;22(4), 2196. Caihong Zhu#, Bei Li#, Karl Frontzek, Yingjun Liu, Adriano Aguzzi. SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease. The Journal of Experimental Medicine. 2019; 216(4), 743–756. Marian Hruska-Plochan#, Bei Li#, Diego Kyburz, Jan Krützfeld, Ulf Landmesser, Adriano Aguzzi, Magdalini Polymenidou. New and emerging roles of small RNAs in neurodegeneration, muscle, cardiovascular and inflammatory diseases. Swiss Medical Weekly. 2015;145, w14192. Caihong Zhu, Zhihao Li, Bei Li, Manuela Pfammatter, Simone Hornemann, Adriano Aguzzi. Unaltered prion disease in mice lacking developmental endothelial locus-1. Neurobiology of Aging. 2019; 76, 208–213. Uli S Herrmann, Anne K Schütz, Hamid Shirani, Danzhi Huang, Dino Saban, Mario Nuvolone, Bei Li, Boris Ballmer, Andreas K O Åslund, Jeffrey J Mason, Elisabeth Rushing, Herbert Budka, Sofie Nyström, Per Hammarström, Anja Böckmann, Amedeo Caflisch, Beat H Meier, K Peter R Nilsson, Simone Hornemann, Adriano Aguzzi. Structure-based drug design identifies polythiophenes as antiprion compounds. Science Translational Medicine. 2015; 7(299), 299ra123. Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of Aging. 2015; 36(5), 1994–2003. Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi. Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways. PLoS Pathogens. 2015; 11(2), e1004662. Tiziana Sonati, Regina R Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman, Dipankar Das, Nat Kav, Roland Riek, Pawel P Liberski, Michael N G James, Adriano Aguzzi. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. Nature. 2013; 501(7465), 102–106. Jeppe Falsig, Tiziana Sonati, Uli S Herrmann, Dino Saban, Bei Li, Karina Arroyo, Boris Ballmer, Pawel P Liberski, Adriano Aguzzi. Prion pathogenesis is faithfully reproduced in cerebellar organotypic slice cultures. PLoS Pathogens. 2012; 8(11), e1002985.