李爱玲 - 复旦大学 - 基础医学院

个人简介

主要从事肿瘤生物学研究，在炎症诱发肿瘤和DNA损伤诱发肿瘤的机制方面做出了原创性发现。以通讯作者（含共同）发表论文包括Nature Immunology、PNAS、Autophagy、Cell Reports、Journal of Experimental Medicine、EMBO Reports、EMBO Molecular Medicine、Clinical Cancer Research等，主要发现和结论被国际权威杂志多次重点介绍和评述。获国家杰出青年科学基金、中国青年科技奖，享受政府特殊津贴。作为负责人，主持国家重点研发计划、国家重大科学仪器专项、国家973课题、国家自然科学基金项目等科研任务。先后获国家自然科学二等奖、北京市科学技术一等奖和国家科技进步创新团队奖等。荣誉与获奖 2010年获国家杰出青年科学基金 2011年获中国青年科技奖 2014年被评为国家创新人才推进计划中青年科技创新领军人才 2017年享受国家政府特殊津贴

研究领域

肿瘤生物学行为及其分子调控机制生物医学分析与生物安全

近期论文

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Hui-Yan Li, Hui Liu, Chen-Hui Wang, Ji-Yan Zhang, Jiang-Hong Man, Yan-Fei Gao, Pei-Jing Zhang, Wei-Hua Li, Jie Zhao, Xin Pan, Tao Zhou, Wei-Li Gong, Ai-Ling Li*（共同通讯作者） and Xue-Min Zhang*. Deactivation of IKK by CUE domain containing 2 (CUEDC2) via recruitment of the protein phosphatase PP1. Nature Immunology, 2008, 9:533-541. Zhao Jian, Bing Liang, Xin Pan, Guang Xu, Sai-Sai Guo, Ting Li, Tao Zhou, Ying-Bin Xiao*, and Ai-Ling Li*（通讯作者）. CUEDC2 modulates cardiomyocytes oxidative capacity by regulating GPX1 stability. EMBO Molecular Medicine, 2016 Jul 1;8(7):813-29. doi: 10.15252/emmm.201506010. Xin Pan, Jie Zhao, Wei-Na Zhang, Hui-Yan Li, Rui Mu, Tao Zhou, Hai-Ying Zhang, Wei-Li Gong, Ming Yu, Jiang-Hong Man, Pei-Jing Zhang, Ai-Ling Li* （共同通讯作者） and Xue-Min Zhang*. Induction of SOX4 by DNA damage is critical for p53 stabilization and function. PNAS, 2009, 106(10):3788-3793. Guang Xu, Ting Li, Jiayi Chen, Changyan Li, Haixin Zhao, Chengcheng Yao, Hua Dong, Kaiqing Wen,Kai Wang, Jie Zhao, Qing Xia, Tao Zhou, Huafeng Zhang, Ping Gao, Ailing Li（共同通讯作者） and Xin Pan. Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing. Autophagy, 2018,14(10):1818-1830. Xiaoyan Zhan, Saisai Guo, Yuanyuan Li, Haowen Ran, Haohao Huang, Lanjuan Mi, Jin Wu, Xinzheng Wang, Dake Xiao, Lishu Chen, Da Li, Songyang Zhang, Xu Yan, Yu Yu, Tingting Li, Qiuying Han, Kun He, Jiuwei Cui, Tao Li, Tao Zhou, Jeremy N. Rich, Shideng Bao, Xuemin Zhang, Ailing Li （共同通讯作者）, and Jianghong Man. Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation. Journal of Experimental Medicine, 2020, 217(5): e20191340. doi: 10.1084/jem.20191340. Song N, Qi Q, Cao R, Qin B, Wang B, Wang Y, Zhao L, Li W, Du X, Liu F, Yan Y, Yi W, Jiang H, Li T, Zhou T, Li HY, Xia Q, Zhang XM, Zhong W, Li AL（共同通讯作者）, Duan X. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses. Cell Reports, 2019 Aug 27; 28(9):2386-2396.e5. Lingyu Li, Wei Li, Naifei Chen, Haixin Zhao, Guang Xu, Yijing Zhao, XinPan, Xiaoying Zhang, Lei Zhou, Dehai Yu, Ailing Li*（共同通讯作者）, Ji-Fan Hu*, Jiuwei Cui1*. FLI1 exonic circular RNAs as a novel oncogenic driver to promote tumor metastasis in small cell lung cancer. Clin Cancer Res.2019 Feb 15;25(4):1302-1317. Xiuying Zhong＃, Shengya Tian＃, Xiang Zhang,XinweiDiao, Fangting Dong, Jie Yang, Zhaoyong Li, Linchong Sun, Lin Wang, Xiaoping He, Gongwei Wu, Xin Hu, Lihua Wang, Libing Song, Huafeng Zhang, Xin Pan, Ailing Li*（共同通讯作者）, Ping Gao*. CUE domain containing protein-2 promotes the Warburg effect and tumorigenesis. EMBO Reports, 2017 May;18(5):809-825. Hai-Ying Zhang, Jiang-Hong Man, Bing Liang, Tao Zhou, Chen-Hui Wang, Tao Li, Hui-Yan Li, Wei-Hua Li, Bao-Feng Jin, Pei-Jing Zhang, Jie Zhao, Xin Pan, Kun He, Wei-Li Gong, Xue-Min Zhang*, and Ai-Ling Li*（通讯作者）. Tumor-targeted delivery of biologically active TRAIL protein. Cancer Gene Therapy, 2010, 17:334-343. Na Wang, Yuan Cao, Wei Song, Kun He, Tao Li, Jie Wang, Bin Xu, Hai-yan Si, Cheng-Jin Hu, Ai-Ling Li*（通讯作者）. Serum peptide pattern differentially diagnoses Hepatitis B Virus-related hepatocellular carcinoma from liver cirrhosis. Journal of Gastroenterology and Hepatology, 2014, 29:1544–1550.