个人简介
教育经历
2004/09-2012/06，华中科技大学，同济医学院临床医学八年制，医学博士
工作经历
2020/1-至今，复旦大学上海医学院基础医学院，青年研究员
2016/11-2019/12，华中科技大学同济医学院，附属同济医院神经内科，住院 医师/主治医师
2013/01-2016/10，美国罗切斯特大学中心，神经转化医学研究中心，博士后/助理教授
2012/07-2012/12，华中科技大学，附属同济医院神经内科，住院医师
获得人才项目
上海市科委“科技创新计划”，启明星人才项目，星形胶质细胞调控睡眠觉醒的作用和机制，21QA1401100， 2021/07-2024/06, 40万，在研，主持
中国科协青年托举人才项目，中国睡眠研究会，2020/1-2023/1
研究领域
皮质星形胶质细胞参与睡眠-觉醒调控的机制探讨
深部脑区/核团星形胶质细胞在癫痫发放、运动、情绪模型中的调控角色探讨
慢性睡眠碎片化病理生理机制与神经退行性疾病发病机制的关联分析
近期论文
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Fengfei Ding#(第一作者) John O’Donnell#, Qiwu Xu, Ning Kang, Nanna Goldman, Maiken Nedergaard*, Changes in the composition of brain interstitial ions control the sleep-wake cycle, Science, 2016, 352(6285): 550-555 (ESI, Citation 84); IF = 41.037
Fengfei Ding #(第一作者) , John O'Donnell#, Alexander S.Thrane#, Douglas Zeppenfeld, Hongyi Kang, Lulu Xie, Fushun Wang, Maiken Nedergaard*, α1-Adrenergic receptors mediate coordinated Ca2+ signaling of cortical astrocytes in awake, behaving mice, Cell Calcium, 2013, 54(6): 387-394 (Citation 143); IF = 3.932
Li Ba, Lifang Huang, Ziyu He, Saiyue Deng, Yi Xie, Min Zhang, Cornelius Jacob, Emanuele Antonecchia, Yuqing Liu, Wenchang Xiao, Qingguo Xie, Zhili Huang, Chenju Yi, Nicola D’Ascenzo#, Fengfei Ding#, Does chronic sleep fragmentation lead to Alzheimer’s disease in young wildtype mice?, Front Aging Neurosci, 2021,Dec, online.
Yi Xie, Li Ba, Min Wang, Saiyue Deng, Simiao Chen, Lifang Huang, Min Zhang, Wei Wang, Fengfei Ding# , Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation. CNS Neurosci Ther, 2020; 00; 1:13;
Yi Xie, Saiyue Deng, Simiao Chen, Xuejiao Chen, Wenwen Lai, Lifang Huang, Li Ba, Wei Wang, Fengfei Ding# , A chronic sleep fragmentation model using vibrating orbital rotor to induce cognitive deficit and anxiety-like behavior in young wild-type mice, J Vis Exp, 2020;(163);
Qiong Wang, Zhen Wang, Yeye Tian, Huaqiu Zhang, Yongkang Fang, Zhiyuan Yu, Wei wang, Minjie Xie, Fengfei Ding# ，Inhibition of astrocyte connexin 43 channels facilitates the differentiation of oligodendrocyte precursor cells under hypoxic conditions in vitro, J Mol Neurosci, 2018,64(4)：591-600
Fengfei Ding#，Guibing Zhang#, Lu Liu, Lizhong Jiang, Rui Wang, Yunjie Zheng, Guoping Wang, Minjie Xie*, Yaqi Duan*, Involvement of cationic channels in proliferation and migration of human mesenchymal stem cells, Tissue Cell, 2012, 44(6): 358-364
John O’Donnell#, Fengfei Ding, Maiken Nedergaard*, Distinct functional states of astrocytes during sleep and wakefulness: Is norepinephrine the master regulator? Current Sleep Medicine Reports, 2015, 1(1): 1-8；
Minghuan Wang#, Fengfei Ding , Saiyue Deng, Xuequn Guo, Wei Wang, Jeffrey Iliff*, Maiken Nedergaard*, Focal solute trapping and global glymphatic impairment in a murine model of multiple microinfarcts. Journal of Neuroscience. 2017, 37(11): 2870-2877
Marta Obara-Michlewska#, Fengfei Ding, Mariusz Popek, Alexei Verkhratsky, Maiken Nedergaard, Magdalena Zielinska, Jan Albreckt*, Intersitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure, Neurochemistry International, 2018, 118:286-291;
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