何颖芳 - 复旦大学 - 放射医学研究所

个人简介

何颖芳，复旦大学上海医学院青年副研究员。2021年于苏黎世联邦理工大学放射性药物科学中心获得自然科学博士学位，随后在苏黎世联邦理工大学有机化学所从事博士后研究工作，2022年由复旦大学引进回国工作。以第一作者身份在Journal of Nuclear Medicine (1篇), Journal of Medicine Chemistry (2篇), European Journal of Medicinal Chemistry (1篇)等国际药物/核医学主流期刊发表论文7篇，申请中外发明3项。2022年入选欧洲药物化学联合会（EFMC）青年科学家指导计划（2022 YSN-Mentoring Programme）；2023年入选上海市白玉兰人才计划浦江项目、上海市白玉兰人才计划（原上海领军人才（海外）项目）。

近期论文

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He, Y.; Kr?mer, S-D.; Grether, U.; Witter, M,; et al. Identification of (R)-[18F]YH134 for monoacylglycerol lipase neuroimaging and the exploration of its use for central nervous system and peripheral drug development. J Nucl Med. (医学一区top，Accepted) He, Y.; Grether, U.; Taddio, F. M.; Meier, C.; et al. Multi-parameter optimization: Development of a morpholin-3-one derivative with an improved kinetic profile for imaging monoacylglycerol lipase in the brain. Eur J Med Chem. 2022, 243, 1140750 (药物化学一区top). He,Y.; Schild, M.; Grether, U.; Benz, J.; et al. Development of high brain-penetrant and reversible monoacylglycerol lipase PET tracers for neuroimaging. J Med Chem. 2022, 65, 3, 2191-2207 (药物化学一区top). He,Y.; Gobbi, L.; Herde, M. A.; Rombach, D.; et al. Discovery, synthesis and evaluation of novel reversible monoacylglycerol lipase radioligands bearing a morpholine-3-one scaffold. Nucl Med Biol. 208-109,24-32. He,Y.; Whitehead, D. M.; Briard, E.; Numao, S.; et al. Evaluation of 5H-Thiazolo[3,2-α]Pyrimidin-5-Ones as Potential GluN2A PET Tracers. ChemMedChem 2020, 15, 1-15 (Front cover). He,Y.; Mu, L.; Ametamey, S. M.; Schibli, R. Recent Progress in Allosteric Modulators for GluN2A Subunit and Development of GluN2A-Selective Nuclear Imaging Probes. J. Label. Compd. Radiopharm. 2019, 62(8), 552–560. He,Y*.; Xie, F*.; Ye, J.; Deuther-Conrad, W.; et al. 1-(4-[18F]Fluorobenzyl)-4- ((tetrahydrofuran-2-yl)methyl)piperazine: A suitable radioligand with low lipophilicity for imaging sigma-1 receptors in the brain. J. Med. Chem., 2017, 60 (10), 4161-4172. (*These authors contributed equally) (药物化学一区top) Tian, J.; He, Y.; Deuther-Conrad, W.; Fu, H.; et al. Synthesis and Evaluation of New 1-Oxa-8-Azaspiro[4.5]Decane Derivatives as Candidate Radioligands for Sigma-1 Receptors. Bioorganic Med. Chem. 2020, 28 (14), 115560. Herde, M. A.; Boss, S.; He, Y.; Schibli. R.; et al. Ketamine and Ceftriaxone-Induced Alterations in Glutamate Levels Do Not Impact the Specific Binding of Metabotropic Glutamate Receptor Subtype 5 Radioligand [18F]PSS232 in the Rat Brain. Pharmaceuticals. 2018, 11(3), 83. Wang, L.; Ye, J.; He,Y.; Deuther-Conrad, W.; et al. 18F-Labeled Indole-Based Analogs as Highly Selective Radioligands for Imaging Sigma-2 Receptors in the Brain. Bioorganic Med. Chem. 2017, 25 (14), 3792–3802. Jia, H.; Cai, Z.; Holden. D.; He,Y.; et al. Positron Emission Tomography Imaging Evaluation of a Novel 18F-Labeled Sigma-1 Receptor Radioligand in Cynomolgus Monkeys. ACS Chem. Neurosci. 2020, 11, 11, 1673–1681.