王帅 - 复旦大学

个人简介

学习工作经历 2010.9-2014.7, 锦州医科大学, 药学院, 学士 2014.9-2017.7, 郑州大学, 药学院, 硕士 2017.9-2021.7, 郑州大学, 药物研究院, 博士 2019.9-2021.2, 哈佛医学院, 戈登医学影像中心, 药物化学专业联合培养博士 2021.7-2022.7, 复旦大学, 化学系, 科研助理 2022.7至今, 复旦大学, 化学系, 青年副研究员 2023.10至今, 中国药学会，中国药物化学专业委员会财务秘书

研究领域

基于计算机辅助和药物作用机制抗病毒创新药物研究基于计算机辅助和药物作用机制抗肿瘤创新药物研究多样性化合物库及新药筛选平台的构建

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Wang, J. S., Zhao, K. X., Zhang K., Pannecouque, C.; Clercq, E.; Wang, S.*; Chen, F. E.*, Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility, Bioorg. Chem.2024, 147, 107340. Sang, Y. L.; Pannecouque, C.; Clercq, E.; Wang, S.*; Chen, F. E.*, Fragment hopping-based design of novel biphenyl-DAPY derivatives as potent NNRTIs featuring significantly improved anti-resistance efficacy. J. Med. Chem.2023, 66, 4755-4767. Sang, Y. L.; Pannecouque, C.; Clercq, E.; Wang, S.*; Chen, F. E.*, Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability. Acta Pharm. Sin.B, 2023, 13, 3054-3066. Zhao, L. M.; Pannecouque, C.; Clercq, E.; Wang, S.; Chen, F. E. Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility. Acta Pharm. Sin. B2023, 13, 4906-4917. Zhou, R. L.; Ju, Z.; Pannecouque, C.; Clercq, E.; Wang, S.*; Chen, F. E.*, Structure-guided design of novel HEPT analogs with enhanced potency and safety: From Isopropyl-HEPTs to Cyclopropyl-HEPTs. Eur. J. Med. Chem.2023, 246, 114939. Ling, X.; Hao, Q. Q.; Huang, W. J.; Pannecouque, C.; De Clercq, E.; Wang, S.*; Chen, F. E.*, Development of novel S-N3-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity. Eur. J. Med. Chem.2023, 247, 115042. Zhao, L. M.; Pannecouque, C.; De Clercq, E.; Wang, S.*; Chen, F. E.*, Structure-directed expansion of biphenyl-pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with significantly improved potency and safety. Chin. Chem. Lett.2023, 108261. Hao, Q. Q.; Chen, X. M.; Pannecouque, C.; De Clercq, E.; Wang, S.*; Chen, F. E.*, Structure-directed linker optimization of novel HEPTs as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Chem. 2023, 133, 106413. Jin, X.; Wang, S.; Zhao, L. M.; Huang, W. J.; Zhang, Y. X.; Pannecouque, C.; De Clercq, E.; Meng, G.*; Piao, H. R.*; Chen, F.*, Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: boosting the safety and metabolic stability. Acta. Pharm. Sin. B2023, 13, 1192-1203. Jin, X.; Zhao, L. M.; Wang, S.; Huang, W. J.; Zhang, Y. X.; Pannecouque, C.; De Clercq, E.; Chen, F. E.*, Structure-based discovery of novel NH2-biphenyl-diarylpyrimidines as potent non-nucleoside reverse transcriptase inhibitors with significantly improved safety: from NH2-naphthyl-diarylpyrimidine to NH2-biphenyl-diarylpyrimidine. J. Med. Chem.2022, 65 (12), 8478-8492. Zhao, L. M.; Wang, S.; Pannecouque, C.; De Clercq, E.; Piao, H. R.*; Chen, F. E.*, Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability. Eur. J. Med. Chem. 2022, 240, 114581. Hao, Q.; Wang, S.; Huang, W.; Zhang, Y.; Pannecouque, C.; De Clercq, E.; Chen, F.*, Structure-based design of [(2-hydroxyethoxy)methyl]-6-(phenylthio)-thymine derivatives as nonnucleoside HIV-1 reverse transcriptase inhibitors: from HEPTs to sulfinyl-substituted HEPTs. Bioorg. Chem.2022, 126, 105880. Wang, S.; Chen, F. E.*, Small-molecule MDM2 inhibitors in clinical trials for cancer therapy. Eur. J. Med. Chem.2022, 236, 114334. Wang, S.1; Wang, S. Q.1; Teng, Q. X.; Lei, Z. N.; Chen, Z. S.; Chen, X. B.*; Liu, H. M.*; Yu, B.*, Discovery of the triazolo[1,5-a]pyrimidine-based derivative WS-898 as a highly efficacious and orally bioavailable ABCB1 inhibitor capable of overcoming multidrug resistance. J. Med. Chem. 2021, 64 (21), 16187-16204. Wang, S.; Yuan, X. H.; Wang, S. Q.; Zhao, W.; Chen, X. B.; Yu, B.*, FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application. Eur. J. Med. Chem.2021, 214, 113218. Wang, S.; Gong, L. C.; El Fakhri, G.*; Wang, J. F.*, Efficient synthesis of 6,6′-diamido-2,2′-dipicolylamine ligands for potential phosphate anion sensing. New J. Chem. 2021, 45 (36), 16833-16840. Huo, J. L.1; Wang, S.1; Yuan, X. H.; Yu, B.*; Zhao, W.*; Liu, H. M.*, Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents. Eur. J. Med. Chem.2021, 211, 113108. Wang, S.1; Shen, D. D.1; Zhao, L. J.1; Yuan, X. H.; Cheng, J. L.; Yu, B.*; Zheng, Y. C.*; Liu, H. M.*, Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors. Chin. Chem. Lett. 2020, 31 (2), 418-422. Wang, S.1; Wang, S. Q.1; Teng, Q. X.1; Yang, L. L.; Lei, Z. N.; Yuan, X. H.; Huo, J. F.; Chen, X. B.; Wang, M. R.; Yu, B.*; Chen, Z. S.*; Liu, H. M.*, Structure-based design, synthesis, and biological evaluation of new triazolo[1,5-a]pyrimidine derivatives as highly potent and orally active ABCB1 modulators. J. Med. Chem.2020, 63 (24), 15979-15996. Wang, S.1; Ma, X. B.1; Yuan, X. H.; Yu, B.*; Xu, Y. C.*; Liu, H. M.*, Discovery of new [1,2,4] triazolo[1,5-a]pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur. J. Med. Chem.2020, 203, 112630. Lu, N.1; Huo, J. L.1; Wang, S.1; Yuan, X. H.; Liu, H. M.*, Drug repurposing: discovery of troxipide analogs as potent antitumor agents. Eur. J. Med. Chem.2020, 202, 112471. Shi, X. J.1; Wang, S.1; Li, X. J.1; Yuan, X. H.; Cao, L. J.; Yu, B.*; Liu, H. M.*, Discovery of tofacitinib derivatives as orally active antitumor agents based on the scaffold hybridization strategy. Eur. J. Med. Chem.2020, 203, 112601. Yuan, X. H.1; Wang, S.1; Cheng, J. L.; Yu, B.*; Liu, H. M.*, HFIP-promoted catalyst-free cascade reactions for the synthesis of biologically relevant 3,3-di(indolyl)indolin-2-ones from indoles and isatins. Chin. Chem. Lett. 2020, 31 (9), 2465-2468. Wang, S.1; Zhao, L. J.1; Shi, X. J.1; Ding, L. N.1; Yang, L. L.; Wang, Z. Z.; Shen, D. D.; Tang, K.; Li, X. J.; Mamun, M.; Li, H. J.; Yu, B.*; Zheng, Y. C.*; Wang, S. M.*; Liu, H. M.*, Development of highly potent, selective, and cellular active triazolo[1,5-a]pyrimidine-based inhibitors targeting the DCN1-UBC12 protein-protein interaction. J. Med. Chem.2019, 62 (5), 2772-2797. He, P. X.1; Niu, S. H.1; Wang, S.1; Shi, X. J.; Feng, S. Q.; Du, L. N.; Zhang, X. Y.; Ma, Z. L.; Yu, B.*; Liu, H. M.*, Discovery of WS-157 as a highly potent, selective and orally active EGFR inhibitor. Acta. Pharm. Sin. B 2019, 9 (6), 1193-1203. Wang, S.1; Li, Z. R.1; Suo, F. Z.; Yuan, X. H.; Yu, B.*; Liu, H. M.*, Synthesis, structure-activity relationship studies and biological characterization of new [1,2,4]triazolo[1,5-a]pyrimidine-based LSD1/KDM1A inhibitors. Eur. J. Med. Chem.2019, 167, 388-401. Li, Z. R.1; Wang, S.1; Yang, L.; Yuan, X. H.; Suo, F. Z.; Yu, B.*; Liu, H. M.*, Experience-based discovery (EBD) of aryl hydrazines as new scaffolds for the development of LSD1/KDM1A inhibitors. Eur. J. Med. Chem. 2019, 166, 432-444. Wang, S.1; Zhao, L. J.1; Zheng, Y. C.; Shen, D. D.; Miao, E. F.; Qiao, X. P.; Zhao, L. J.; Liu, Y.; Huang, R.; Yu, B.*; Liu, H. M.*, Design, synthesis and biological evaluation of [1,2,4]triazolo[1,5-a]pyrimidines as potent lysine specific demethylase 1 (LSD1/KDM1A) inhibitors. Eur. J. Med. Chem. 2017, 125, 940-951.