冯喆 - 复旦大学 - 生命科学学院

个人简介

2011年获英国帝国理工大学学士学位，2016年获英国牛津大学病理学博士学位（Prof. Jordan Raff实验组，硕博连读）。此后在同实验室从事博士后研究。2017年入职香港科技大学，担任研究助理教授（张明杰院士实验室组），获选港科大高研院青年学人荣誉，领导主持香港研究资助局优配研究金项目。2021年获得国家和上海人才计划支持，人才引进复旦大学生命科学院。

研究领域

中心体的组装与调控机制中心体功能障碍对于癌症、发育类等疾病的致病机理相分离介导的无膜细胞器组装和调控的功能机理

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Feng, Z., Jia, B., Tao, J. and Zhang, M. (2021) “IRSp53 promotes postsynaptic density formation and actin filament bundling via phase separation”. Journal of Cell Biology, under revision. Feng, Z.*, Caballe, A.*, Wainman, A.*, Johnson, S.*, Haensele, A.F.M., Cottee, M.A., Conduit, P.T., Lea, S.M., and Raff, J.W. (2017) “Structural basis for mitotic centrosome assembly in flies”. Cell169, 1078-1089. (Highlighted in Faculty 1000) Conduit, P.T.*, Feng, Z.*(Equal contribution), Richens, J.H., Baumbach, J., Wainman, A., Bakshi, S., Dobbelaere, J., Johnson, S., Lea, S.M., and Raff, J.W. (2014) “The centrosome-specific phosphorylation of Cnn by Polo/Plk1 drives Cnn scaffold assembly and centrosome maturation”. Developmental Cell 28, 659-669. (Highlighted in Faculty 1000) Feng, Z., Jia, B., and Zhang, M. (2021) “Liquid-liquid phase separation in biology: specific stoichiometric molecular interactions vs promiscuous interactions mediated by disordered sequences”. Biochemistry 60, 2397-2406. Wu, X., Cai, Q., Feng, Z., and Zhang, M. (2020) “Liquid-liquid phase separation in neuronal development and synaptic signaling”. Developmental Cell 55, 18-29. Feng, Z.,Chen, X., Wu, X., and Zhang, M. (2019) “Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications”. Journal of Biological Chemistry294, 14823-14835. Li, Z., Liu, H., Li, J., Yang, Q., Feng, Z., Li, Y., Yang, H., Yu, C., Wan, J., Liu, W., and Zhang, M. (2019) “Homer tetramer promotes actin bundling activity of Drebrin”. Structure27, 27-38. Feng, Z., Chen, X., Zeng, M., and Zhang, M. (2018) “Phase separation as a mechanism for assembling dynamic postsynaptic density signaling complexes”. Current Opinion in Neurobiology 57, 1-8. Feng, Z., Zeng, M., Chen, X., and Zhang, M. (2018) “Neuronal synapses: microscale signal processing machineries formed by phase separation?”. Biochemistry 57, 2530-2539.