个人简介
1998年进入复旦大学生命科学学院,2002年获学士学位。2002年-2008年就读于复旦大学发育生物学研究所,获得博士学位。2008-2011年在美国斯克利普斯研究所从事博士后研究。2011-2017年担任德克萨斯大学西南医学中心讲师。2017-2019年作为联合创始人和首席技术官筹建和负责上海近岸生物科技有限公司的新药研发,并作为课题负责人获得科技部国家重大新药创制专项基金支持。2019年被复旦大学发育生物学研究所聘为青年研究员。2020年起兼任复旦大学附属中山医院肿瘤内科双聘PI。获上海市浦江人才计划支持。
研究领域
遗传和生理因素引起的免疫调控机制;新型免疫治疗药物研发和临床应用
近期论文
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Yan-Mei Chen#, Yuanting Zheng#, Ying Yu#, Yunzhi Wang#, Qingxia Huang#, Feng Qian#, Lei Sun#, Zhi-Gang Song, Ziyin Chen, Jinwen Feng, Yanpeng An, Jingcheng Yang, Zhenqiang Su, Shanyue Sun, Fahui Dai, Qinsheng Chen, Qinwei Lu, Pengcheng Li, Yun Ling, Zhong Yang, Huiru Tang, Leming Shi, Li Jin, Edward C Holmes, Chen Ding, Tong-Yu Zhu, Yong-Zhen Zhang. Blood molecular markers associated with COVID-19 immunopathology and multi-organ damage. EMBO J.2020 Nov 3;e105896. doi: 10.15252/embj.2020105896.
Meijing Liu, Xuelin Wang, Zheng Li, Rui Zhang, Juan Mu, Yanyu Jiang, Qi Deng*, Lei Sun*.Synergistic effect of ibrutinib and CD19 CAR-T cells on Raji cells in vivo and in vitro. Cancer Sci.2020 Sep 2;111:4051-4060.
Lei Sun, Zhengfan Jiang, Victoria A. Acosta-Rodriguez, Michael Berger, Xin Du, Jin Huk Choi, Jianhui Wang, Kuan-wen Wang,Gokhul K. Kilaru, Jennifer A. Mohawk,Jiexia Quan, Lindsay Scott,Sara Hildebrand,Xiaohong Li,Miao Tang, Xiaoming Zhan, Anne R. Murray, Diantha La Vine, Eva Marie Y. Moresco, Joseph S. Takahashi, Bruce Beutler. HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med.2017 Nov 2;214(11):3263-3277.
Zhisheng Ye#, Lei Sun#, Rongbo Li#, Min Han, Yuan Zhuang, Xiaohui Wu, Tian Xu. Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. Int J Biol Sci.2016 Jun 7;12(8):911-6.
Katharina Brandl#, Lei Sun#, Christina Neppl, Owen M. Siggs, Sylvain M. Le Gall, Wataru Tomisato, Xiaohong Li, Xin Du, Daniela N. Maennel, Carl P. Blobel, Bruce Beutler. MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. PNAS 2010 Nov 16;107(46):19967-19972.
Lei Sun, Xiaohui Wu*, Min Han*, Tian Xu*, Yuan Zhuang*. A Mitotic Recombination System for Mouse Chromosome 17. PNAS 2008 March 18;105(11):4237-4241.