罗凌飞 - 复旦大学 - 生命科学学院

个人简介

罗凌飞复旦大学浩清特聘教授、生命科学学院院长。1999年毕业于南京大学获学士学位，2004年毕业于德国哥廷根大学获博士学位，2004-2006年在德国马克斯普朗克生物物理化学研究所从事博士后研究工作。中国细胞生物学学会副理事长（2019-今），国家自然科学基金委员会生命科学部第六、七届专家咨询委员会委员（2014-2020）、第九届国家杰出青年科学基金大评委会委员（2018-2020）。国家杰出青年科学基金获得者（2009），国家级人才计划入选者（2013、2019），中国青年五四奖章获得者（2013），国务院特殊津贴获得者（2019）。作为首席科学家或项目负责人先后主持国家“973计划”项目（2008、2014）、国家自然科学基金重大项目（2021）和国家重点研发计划项目（2021）。

研究领域

器官再生修复及其发育生物学基础：本课题组以斑马鱼和小鼠为主要模式动物，以脑血管和消化器官再生修复机制及其发育生物学基础和药物开发为主要研究方向。近年来取得淋巴管和巨噬细胞在脑血管再生修复中的重要功能、肝脏重度损伤下由胆管细胞转分化实现再生等重要原创性科学发现。目前课题组具体研究方向包括：1）消化器官再生的细胞与分子基础及其药物开发；2）脑血管再生修复的细胞与分子基础及其药物开发；3）消化器官发育的细胞谱系及命运决定机制研究；4）器官再生能力的物种差异及其形成机制。

近期论文

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Yun Yang#, Shuang Li#, Lingfei Luo*. (2023). Responses of organ precursors to correct and incorrect inductive signals. Trends in Cell Biology (Online ahead of print) doi: 10.1016/j.tcb.2023.08.008. (IF: 21.2) Pengcheng Cai#, Rui Ni#, Mengzhu Lv#, Huijuan Liu, Jieqiong Zhao, Jianbo He,Lingfei Luo*. (2023). VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis. Cell Reports42(9), 113028. (IF: 10.0) Xiangyong Wei#, Xinmiao Tan#, Qi Chen#, Yan Jiang, Guozhen Wu, Xue Ma, Jialong Fu, Yongyu Li, Kai Gang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2023). Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish.Cell Reports42(7), 112660. (IF: 10.0) Yun Yang#, Yuanyuan Li#, Jialong Fu#, Yanfeng Li, Shuang Li, Rui Ni, Qifen Yang, Lingfei Luo*. (2022). Intestinal precursors avoid being mis-induced to liver cells by activating Cdx-Wnt inhibition cascade. Proceedings of the National Academy of Sciences USA119(45), e2205110119. (IF: 12.8) Junren Zhang#, Yang Zhou#, Shuang Li, Dashuang Mo, Jianlong Ma, Rui Ni, Qifen Yang, Jianbo He*, Lingfei Luo*. (2022). Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports39(1), 110596. (IF: 10.0) Jingying Chen#, Xiuhua Li#, Rui Ni, Qi Chen, Qifen Yang, Jianbo He, Lingfei Luo*. (2021). Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell56(22), 3115–3127. (IF: 13.4) Pengcheng Cai#, Xiaoyu Mao#, Jieqiong Zhao, Li Nie, Yan Jiang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2021). Farnesoid X Receptor is required for the redifferentiation of bi-potential progenitor cells during biliary-mediated zebrafish liver regeneration. Hepatology74(6),3345–3361. (IF: 17.3) Yun Yang#, Hao Wang#, Jia He, Wenchao Shi, Zhanmei Jiang, Lina Gao, Yan Jiang, Rui Ni, Qifen Yang, Lingfei Luo*. (2021). A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proceedings of the National Academy of Sciences USA118(25), e2025793118. (IF: 12.8) Jiaobo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai, Lingfei Luo*. (2019). Mammalian target of rapamycin complex 1 signaling is required for the dedifferentiation from biliary cell to bipotential progenitor cell in zebrafish liver regeneration. Hepatology70(6), 2092–2106. (IF: 17.3，封面论文) Jingying Chen, Jianbo He, Rui Ni, Qifen Yang, Yaoguang Zhang, Lingfei Luo*. (2019). Cerebrovascular injuries induce lymphatic invasion into brain parenchyma to guide vascular regeneration in zebrafish. Developmental Cell49(5), 697–710. (IF: 13.4，封面论文) Zigang Cao, Xiaoyu Mao, Lingfei Luo*. (2019). Germline stem cells drive ovary regeneration in zebrafish. Cell Reports26(7), 1709–1717. (IF: 10.0) Chi Liu, Chuan Wu, Qifen Yang, Jing Gao, Li Li, Deqin Yang*, Lingfei Luo*. (2016). Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction. Immunity44(5), 1162–1176. (IF: 43.5) Jianbo He, Huiqiang Lu, Qingliang Zou, Lingfei Luo*. (2014). Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology146(3), 789–800. (IF: 33.9，封面论文) Huiqiang Lu, Jun Ma, Yun Yang, Wenchao Shi, Lingfei Luo*. (2013). EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Developmental Cell24(5), 543–553. (IF: 13.4)