高明君 - 复旦大学 - 生命科学学院

个人简介

2002-2006在南京师范大学获得理学学士，2006-2013在中国科学院上海植物生理生态研究所获得博士学位，之后于2014-2021年在英国剑桥大学Sainsbury实验室从事博士后研究。2022年2月加入复旦大学生命科学学院，任青年研究员。其研究领域聚焦于作物免疫的分子和生化机理：1）在水稻中鉴定到一条全新的、以钙离子感受器ROD1为核心并受气候选择的免疫信号通路，提出了蛋白结构模拟所介导的植物-病原菌共进化模型；2）发现了调控水稻抗病反应的新型脂类代谢分子；3）揭示了禾谷类作物感知和响应温度变化的分子机理，为植物抗病性的环境调控研究奠定了基础。相关成果发表于Genome Biology (2023)、Cell (2021)、PLoS Pathogens(2017)等期刊，获得国内外同行关注。2022年入选国家海外高层次人才青年项目、上海市领军人才（海外）青年项目和上海市浦江人才计划项目。获得上海市植物病理学会颁发的2022年“青年科学家奖”。

研究领域

植物免疫与环境应答通过遗传学、分子生物学、生物化学和细胞生物学等手段揭示植物抵抗病原菌的信号通路，解析环境因子调控作物免疫的分子机制，结合基因编辑和分子育种手段提高作物抗病能力，培育抗性、产量和环境适应性相平衡的作物新品种，促进我国绿色农业和绿色生态的发展。

近期论文

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Gao M#, Lu Y#, Geng F, Klose C, Staudt A, Huang H, Nguyen D, Lan H, Lu H, Mockler T, Nusinow D, Hiltbrunner A, Schafer E, Wigge P*, Jaeger K*. (2023). Phytochromes transmit photoperiod information via the Evening Complex in Brachypodium. Genome biology 24(1):256. Gao M#*, Schornack S*. (2023) Antibodies for a bespoke plant immunity. Cell Host Microbe. 31(5):683-684. Lu H, Gao M*. (2023) Dual functions of a novel effector in the plant and pathogen arms race. Stress Biol. 3(1):33. Gao M#, He Y#, Yin X#, Zhong X#*, Yan B, Chen J, Wu Y, Li X, Huang Y, Gong X, Chang H, Xie S, Liu J, Yue J, Xu J, Zhang G, Deng Y, Wang E, Tharreau D, Wang G, Yang W*, and He Z*. (2021). Ca2+ sensor-mediated ROS scavenging suppresses rice intrinsic immunity and is exploited by a fungal effector. Cell184(21):5391-5404. Gao M#, Yin X#, Yang W#, Lam SM, Tong X, Liu J, Wang X, Li Q, Shui G, He Z*. (2017). GDSL lipases modulate immunity through lipid homeostasis in rice.PLoS Pathogens13(11): e1006724. Gao M, He Z*. (2013). Studies on innate immunity in rice. SCIENTIA SINICA Vitae 43: 1016–1029. Jung J#, Barbosa A#, Hutin S#, Kumita J, Gao M, Derwort D, Silva C, Lai X, Pierre E, Geng F, Kim S, Baek S, Zubieta C, Jaeger KE, Wigge PA*. (2020). A prion-like domain in ELF3 functions as a thermosensor in Arabidopsis. Nature585(7824): 256-260. Hus K, Betekhtin A, Pinski A, Rojek-Jelonek M, Grzebelus E, Nibau C, Gao M, Jaeger KE, Jenkins G, Doonan JH, Hasterok R. (2020). A CRISPR/Cas9-Based Mutagenesis Protocol for Brachypodium distachyon and Its Allopolyploid Relative, Brachypodium hybridum. Front Plant Sci.11:614. Ramos-Sánchez J, Triozzi P, Alique D, Geng F, Gao M, Jaeger K, Wigge P, Allona I, Perales M*. (2019). LHY2 integrates night-length information to determine timing of poplar photoperiodic growth.Curr. Biol.29(14):2402-2406. Yin X#, Zou B#, Hong X, Gao M, Yang W, Zhong X, He Y, Kuai P, Lou Y, Huang J, Hua J*, He Z*. (2018). Rice copine genes OsBON1 and OsBON3 function as suppressors of broad-spectrum disease resistance.Plant Biotechnol. J.16:1476-1487. Jung J#, Domijan M#, Klose C#, Biswas S#, Ezer D#, Gao M, Khattak A, Box M, Charoensawan V, Cortijo S, Kumar M, Grant A, Locke J, Schäfer E, Jaeger K, Wigge P*. (2016). Phytochromes function as thermosensors in Arabidopsis.Science 354: 886-889. Yang W, Gao M, Yin X, Liu J, Xu Y, Zeng L, Li Q, Zhang S, Wang J, Zhang X, and He Z*. (2013). Control of rice embryo development, shoot apical meristem maintenance and grain yield by a novel cytochrome P450. Mol. Plant6: 1945-1960. Yang W#, Ren S#, Zhang X#, Gao M, Ye S, Qi Y, Zheng Y, Wang J, Zeng L, Li Q, Huang S, He Z*. (2011). BENT UPPERMOST INTERNODE1 encodes a class II formin FH5 crucial for actin organization and rice development. Plant Cell 23: 661-680. Chen F, Gao M, Miao Y, Yuan Y, Wang M, Li Q, Mao B, Jiang L, He Z*. (2010). Plasma membrane localization and potential endocytosis of constitutively expressed XA21 proteins in transgenic rice. Mol. Plant3: 917-926. Wang Y, Gao M, Li Q, Wang L, Wang J, Jeon JS, Qu N, Zhang Y, He Z*. (2008). OsRAR1 and OsSGT1 physically interact and function in rice basal disease resistance. Molecular Plant-Microbe Interactions 21: 294-303.