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Nicholson, J. K.*, Kendall, M. D., Osborn, D.* 1983. Cadmium and Mercury Nephrotoxicity. Nature 304:633-635. Brindle, J. T., Antti, H., Holmes, E., Tranter, G., Nicholson, J. K., Bethell, H. W. L., Clarke, S., Schofield, P. M., McKilligin, E., Mosedale, D. E., Grainger, D. J.* 2002. Rapid and Noninvasive Diagnosis of the Presence and Severity of Coronary Heart Disease Using 1H-NMR-Based Metabonomics. Nature Medicine 8:1439-1444. Nicholson, J. K.*, Connelly, J., Lindon, J. C., Holmes, E. 2002. Metabonomics: A Platform for Studying Drug Toxicity and Gene Function. Nature Reviews Drug Discovery 1:153-161. Nicholson, J. K.*, Wilson, I. D. 2003. Understanding 'Global' Systems Biology: Metabonomics and the Continuum of Metabolism. Nature Reviews Drug Discovery 2:668-676. Nicholson, J. K.*, Holmes, E., Lindon, J. C., Wilson, I. D. 2004. The Challenges of Modeling Mammalian Biocomplexity. Nature Biotechnology 22:1268-1274. Wang, Y. L., Holmes, E., Nicholson, J. K., Cloarec, O., Chollet, J., Tanner, M., Singer, B. H., Utzinger, J*. 2004. Metabonomic Investigations in Mice Infected with Schistosoma Mansoni: An Approach for Biomarker Identification. Proc. Natl. Acad. Sci. USA 101:12676-12681. Lindon, J. C.*, Nicholson, J. K., Holmes, E., Keun, H. C., Craig, A., Pearce, J. T. M., Bruce, S. J., Hardy, N., Sansone, S. A., Antti, H., Jonsson, P., Daykin, C., Navarange, M., Beger, R. D., Verheij, E. R., Amberg, A., Baunsgaard, D., Cantor, G. H., Lehman-McKeeman, L., Earll, M., Wold, S., Johansson, E., Haselden, J. N., Kramer, K., Thomas, C., Lindberg, J., Schuppe-Koistinen, I., Wilson, I. D., Reily, M. D., Robertson, D. G., Senn, H., Krotzky, A., Kochhar, S., Powell, J., van der Ouderaa, F., Plumb, R., Schaefer, H., Spraul, M. 2005. Summary Recommendations for Standardization and Reporting of Metabolic Analyses. Nature Biotechnology 23:833-838. Nicholson, J. K.*, Holmes, E., Wilson, I. D. 2005. Gut Microorganisms, Mammalian Metabolism and Personalized Health Care. Nature Reviews Microbiology 3:431-438. Clayton, T. A., Lindon, J. C., Cloarec, O., Antti, H., Charuel, C., Hanton, G., Provost, J. P., Le Net, J. L., Baker, D., Walley, R. J., Everett, J. R., Nicholson, J. K.* 2006. Pharmaco-Metabonomic Phenotyping and Personalized Drug Treatment. Nature 440:1073-1077. Dumas, M. E.*, Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., Mitchell, S. C., Holmes, E., McCarthy, M. I., Scott, J., Gauguier, D., Nicholson, J. K.* 2006. Metabolic Profiling Reveals a Contribution of Gut Microbiota to Fatty Liver Phenotype in Insulin-Resistant Mice. Proc. Natl. Acad. Sci. USA 103:12511-12516. Beckonert, O., Keun, H. C., Ebbels, T. M. D., Bundy, J. G., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2007. Metabolic Profiling, Metabolomic and Metabonomic Procedures for NMR Spectroscopy of Urine, Plasma, Serum and Tissue Extracts. Nature Protocols 2:2692-2703. Dumas, M. E., Wilder, S. P., Bihoreau, M. T., Barton, R. H., Fearnside, J. F., Argoud, K., D'Amato, L., Wallis, R. H., Blancher, C., Keun, H. C., Baunsgaard, D., Scott, J., Sidelmann, U. G., Nicholson, J. K.*, Gauguier, D.* 2007. Direct Quantitative Trait Locus Mapping of Mammalian Metabolic Phenotypes in Diabetic and Normoglycemic Rat Models. Nature Genetics 39:666-672. Holmes, E., Loo, R. L., Stamler, J., Bictash, M., Yap, I. K. S., Chan, Q., Ebbels, T., De Iorio, M., Brown, I. J., Veselkov, K. A., Daviglus, M. L., Kesteloot, H., Ueshima, H., Zhao, L., Nicholson, J. K.*, Elliott, P*. 2008. Human Metabolic Phenotype Diversity and Its Association with Diet and Blood Pressure. Nature 453:396-U50 . Holmes, E., Wilson, I. D., Nicholson, J. K.* 2008. Metabolic Phenotyping in Health and Disease. Cell 134:714-717. Jia, W.*, Li, H., Zhao, L., Nicholson, J. K. 2008. Gut Microbiota: A Potential New Territory for Drug Targeting. Nature Reviews Drug Discovery 7:123-129. Li, M., Wang, B., Zhang, M., Rantalainen, M., Wang, S., Zhou, H., Zhang, Y., Shen, J., Pang, X., Zhang, M., Wei, H., Chen, Y., Lu, H., Zuo, J., Su, M., Qiu, Y., Jia, W., Xiao, C., Smith, L. M., Yang, S., Holmes, E., Tang, H.*, Zhao, G.*, Nicholson, J. K.*, Li, L.*, Zhao, L.* 2008. Symbiotic Gut Microbes Modulate Human Metabolic Phenotypes. Proc. Natl. Acad. Sci. USA 105:2117-2122. Nicholson, J. K.*, Lindon, J. C.* 2008. Systems Biology - Metabonomics. Nature 455:1054-1056. Wang, Y., Utzinger, J., Saric, J., Li, J. V., Burckhardt, J., Dirnhofer, S., Nicholson, J. K., Singer, B. H., Brun, R., Holmes, E.* 2008. Global Metabolic Responses of Mice to Trypanosoma Brucei Brucei Infection. Proc. Natl. Acad. Sci. USA 105:6127-6132. Clayton, T. A., Baker, D., Lindon, J. C., Everett, J. R., Nicholson, J. K.* 2009. Pharmacometabonomic Identification of a Significant Host-Microbiome Metabolic Interaction Affecting Human Drug Metabolism. Proc. Natl. Acad. Sci. USA 106:14728-14733. Beckonert, O., Coen, M., Keun, H. C., Wang, Y., Ebbels, T. M. D., Holmes, E., Lindon, J. C., Nicholson, J. K.* 2010. High-Resolution Magic-Angle-Spinning NMR Spectroscopy for Metabolic Profiling of Intact Tissues. Nature Protocols 5:1019-1032. Want, E. J.*, Wilson, I. D., Gika, H., Theodoridis, G., Plumb, R. S., Shockcor, J., Holmes, E., Nicholson, J. K. 2011. Global Metabolic Profiling Procedures for Urine Using UPLC-MS. Nature Protocols 5:1005-1018. Chan, E. C. Y.*, Pasikanti, K. K., Nicholson, J. K. 2011. Global Urinary Metabolic Profiling Procedures Using Gas Chromatography-Mass Spectrometry. Nature Protocols 6:1483-1499. Swann, J. R., Want, E. J., Geier, F. M., Spagou, K., Wilson, I. D., Sidaway, J. E., Nicholson, J. K.*, Holmes, E.* 2011. Systemic Gut Microbial Modulation of Bile Acid Metabolism in Host Tissue Compartments. Proc. Natl. Acad. Sci. USA 108:4523-4530. Holmes, E., Kinross, J., Gibson, G. R., Burcelin, R., Jia, W., Pettersson, S., Nicholson, J. K.* 2012. Therapeutic Modulation of Microbiota-Host Metabolic Interactions. Science Translational Medicine 4:137rv6. Kinross, J.*, Nicholson, J. K. 2012. Gut Microbiota Dietary and Social Modulation of Gut Microbiota in the Elderly. Nature Reviews Gastroenterology & Hepatology 9:563-564. Nicholson, J. K.*, Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W., Pettersson, S.* 2012. Host-Gut Microbiota Metabolic Interactions. Science 336:1262-1267. Nicholson, J. K.*, Holmes, E., Kinross, J. M., Darzi, A. W., Takats, Z., Lindon, J. C. 2012. Metabolic Phenotyping in Clinical and Surgical Environments. Nature 491:384-392. Balog, J., Sasi-Szabo, L., Kinross, J., Lewis, M. R., Muirhead, L. J., Veselkov, K., Mirnezami, R., Dezso, B., Damjanovich, L., Darzi, A., Nicholson, J. K.*, Takats, Z.* 2013. Intraoperative Tissue Identification Using Rapid Evaporative Ionization Mass Spectrometry. Science Translational Medicine 5:194ra93. Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., Liu, J., Houpt, E., Li, J. V., Holmes, E., Nicholson, J., Knights, D., Ursell, L. K., Knight, R., Gordon, J. I.* 2013. Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor. Science 339:548-554 . Swann, J. R., Spagou, K., Lewis, M., Nicholson, J. K., Glei, D. A., Seeman, T. E., Coe, C. L., Goldman, N., Ryff, C. D., Weinstein, M., Holmes, E.* 2013. Microbial-Mammalian Cometabolites Dominate the Age-Associated Urinary Metabolic Phenotype in Taiwanese and American Populations. Journal of Proteome Research 12:3166-3180 . Zheng, X., Zhao, A.*, Xie, G., Chi, Y., Zhao, L., Li, H., Wang, C., Bao, Y., Jia, W., Luther, M., Su, M., Nicholson, J. K., Jia, W.* 2013. Melamine-Induced Renal Toxicity Is Mediated by the Gut Microbiota. 2013. Science Translational Medicine 5:172ra22. Veselkov, K. A.*, Mirnezami, R., Strittmatter, N., Goldin, R. D., Kinross, J., Speller, A. V. M., Abramov, T., Jones, E. A., Darzi, A., Holmes, E., Nicholson, J. K., Takats, Z. 2014. Chemo-Informatic Strategy for Imaging Mass Spectrometry-Based Hyperspectral Profiling of Lipid Signatures in Colorectal Cancer. Proc. Natl. Acad. Sci. USA 111:1216-1221. Elliott, P.*, Posma, J. M., Chan, Q., Garcia-Perez, I., Wijeyesekera, A., Bictash, M., Ebbels, T. M. D., Ueshima, H., Zhao, L., van Horn, L., Daviglus, M., Stamler, J., Holmes, E., Nicholson, J. K.* 2015. Urinary Metabolic Signatures of Human Adiposity. Science Translational Medicine 7:285ra62. O'Keefe, S. J. D.*, Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., Vipperla, K., Naidoo, V., Mtshali, L., Tims, S., Puylaert, P. G. B., DeLany, J., Krasinskas, A., Benefiel, A. C., Kaseb, H. O., Newton, K., Nicholson, J. K., de Vos, W. M., Gaskins, H. R., Zoetendal, Fat, E. G. 2015. Fat, Fibre and Cancer Risk in African Americans and Rural Africans. Nature Communications 6:6342.