夏螢 - 复旦大学 - 航空航天系

个人简介

夏螢博士，苏州医学院医学系毕业后从事临床工作近四年，其后在原上海医科大学(现复旦大学上海医学院）攻读研究生，获得医学硕士、博士学位后留校任教，担任中西医结合和神经生物学讲师。1988年赴美国耶鲁大学接受博士后训练,6年后在耶鲁大学创建自己的实验室。他于1993被耶鲁大学医学院聘为副研究员(Associate Research Scientist), 1998年晋升为研究员(Research Scientist), 2002年被聘为耶鲁大学医学院副教授(Associate Professor)。2010年在美国休斯顿德州医学中心被聘为德克萨斯州立大学研究生院教授、德克萨斯州立大学医学院教授(Full Professor)、神经外科系副主任(Vice-Chairman of the Department)和学术委员会主席(Chairman of Research and Promotion Committee)。他于2016年受聘为复旦大学特聘教授及上海市针灸机制与穴位功能重点实验室执行主任，并兼任上海市针灸经络研究中心分子神经病学实验室主任。夏螢博士早年的研究兴趣在于心血管调整、针刺原理、内阿片肽和其它递质的相互作用。目前，其实验室用多种现代技术研究δ-阿片受体的功能、缺血缺氧性脑损伤的保护、脑退行性疾患和针刺对神经系统疾病的影响及机理。自创建实验室至今，其课题持续获得美国国立卫生研究院、美国心脏协会、美国儿童出生缺陷基金会、美国大脑麻痹学会、美国史密斯神经病学基金会、美国赫曼基金会、中国自然科学基金委和上海市科委等机构的资助。他多次应邀在美国国立卫生研究院、哈佛大学等世界知名医学机构以及国际会议讲学，并参与评审美国(如National Institutes of Health, US National Science Foundation, American Heart Association, US Civilian Research and Development Foundation等)、欧洲(如Scotland Medical Research of UK，Wellbeing of Women of UK，National Science Center of Poland等)和中国(如中国自然科学基金委、香港政府医药卫生基金委等)等地的科研基金和大量国际杂志的科学论文。 2020年，他和诺贝尔奖获得者屠呦呦教授等学者一起被授予首届Sheikh Zayed国际传统医学奖金质奖章。 2021年，他被联合国工业组织全球科技创新中心授予科技创新奖。

研究领域

夏螢博士早年的研究兴趣在于心血管调整、针刺原理、内阿片肽和其它递质的相互作用。目前，其实验室用多种现代技术研究δ-阿片受体的功能、缺血缺氧性脑损伤的保护、脑退行性疾患和针刺对神经系统疾病的影响及机理。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Xu Y, Chen RH, Zhi F, Sheng SY, Khiati L, Yang YL, Peng Y, Xia Y*. Delta-opioid Receptor, Microglia and Neuroinflammation. Aging and Disease, Early Access (http://www.aginganddisease.org/EN/10.14336/AD.2022.0912), 2022 Journal Impact Factor=9.968 Xu Y, Zhi F, Peng Y, Mao J, Balboni G, Yang Y and Xia Y*. A Critical Role of δ-Opioid Receptor in Anti-microglial Activation Under Stress. Front. Aging Neurosci. 14:847386, 2022. Journal Impact Factor=5.750 Chen Y, He Y, Zhao S, He X, Xue D and Xia Y*. Hypoxic/Ischemic Inflammation, MicroRNAs and δ-Opioid Receptors: Hypoxia/Ischemia-Sensitive Versus-Insensitive Organs. Front. Aging Neurosci. 14: 847374, 2022. Journal Impact Factor=5.750 Luo FB, Xu RF, Song GL, Xue D, He XZ, Xia Y*. Alleviation of TGF-β1 induced tubular epithelial–mesenchymal transition via the δ-opioid receptor. FEBS Journal 288(4): 1243-1258, 2021. Journal Impact Factor = 5.542 Xu Y, Zhi F, Balboni G, Yang YL, Xia Y*. Opposite Roles of delta- and mu-Opioid Receptors in BACE1 Regulation and Alzheimer’s Injury. Frontiers in Cellular Neuroscience 14(88): 1-13, 2020. Journal Impact Factor = 5.505 Xu Y, Zhi F, Mao JH, Peng Y, Shao NY, Balboni G, Yang YL, Xia Y*. δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy. Aging 12(257): 1-25, 2020. Journal Impact Factor = 5.682 Chen YM, He XZ, Wang SM, Xia Y*.δ‐opioid receptors, microRNAs and neuroinflammation in cerebral ischemia/hypoxia. Frontiers in Immunology 11(421): 1-11, 2020. Journal Impact Factor = 7.561 Luo FB, Xu RF, Song GL, Lu H, He XZ,Xia Y*. The δ-Opioid Receptor Differentially regulates MAPKs and anti-inflammatory cytokines in rat kidney epithelial cells under hypoxia. Frontiers in Physiology 10: 1-14, 2020. Journal Impact Factor = 4.566 Shi QQ, Xu RF, Song GL, Lu H, Xue D, He XZ*, Xia Y*. GATA3 suppresses human fibroblasts-induced metastasis of clear cell renal cell carcinoma via an anti-IL6/STAT3 mechanism. Cancer Gene Therapy 27(12): 979-982, 2020. Journal Impact Factor = 5.987 Chen T, Wang QY, Chao DM, Xia TC, Sheng SY, Li ZR, Zhao JN, Wen GQ, Ding GH, Xia, Y*. δ-Opioid receptor activation attenuates the oligomer formation Induced by hypoxia and/or α-synuclein overexpression/mutation through dual signaling pathways. Molecular Neurobiology 56(5): 3463-3475, 2019. Journal Impact Factor = 5.590 Xu Y, Zhi F, Peng Y, Shao NY, Khiati D, Balboni G, Yang YL, Xia Y*. δ-Opioid receptor activation attenuates hypoxia/MPP+-induced downregulation of PINK1: A novel mechanism of neuroprotection against parkinsonism injury. MolecularNeurobiology56(1): 252-266, 2019. Journal Impact Factor = 5.590 Chen, YM, Shi J, Xia TC, Xu RF, He XZ*, Xia Y*. Preservation Solutions for Kidney Transplantation: History, Advances and Mechanisms. Cell transplantation, 28(12): 1472-1489, 2019. Journal Impact Factor = 4.064 Qiu J, Chao DM, Sheng SY, Khiati D, Zhou XY, Xia Y*. δ-opioid receptor-Nrf-2 mediated inhibition of inflammatory cytokines in neonatal hypoxic-ischemic encephalopathy. Molecular Neurobiology 56(7): 5229-5240, 2018. Journal Impact Factor = 5.590 Huang JZ, Ren Y, Xu Y, Chen T, Xia TC, Li ZR, Zhao JN, Hua F, Sheng SY, Xia Y*. The delta-opioid receptor and Parkinson's disease. CNS Neuroscience Therapeutics 24(12): 1089-1099, 2018. Journal Impact Factor = 5.243 Asakawa T, Zong L, Wang L, Xia Y, Namba H. Unmet challenges forrehabilitation after stroke in China. Lancet 390: 121-122, 2017. Journal Impact Factor = 79.323 Asakawa T, Fang H, Sugiyama K, Nozaki T, Yang YL, Hua F, Ding GH, Hong Z, Fenoy AJ, Villarreal SJ, Chao DM, Onoe H, Suzuki K, Mori N, Namba H, Xia Y*. Animal behavioral assessments in current research of Parkinson’s disease. Neuroscience & Biobehavioral Reviews 65: 63-94, 2016. Journal Impact Factor = 8.989 Asakawa T, Fang H, Sugiyama K, Nozaki T, Hong Z, Suzuki K, Mori N, Yang Y, Hua F, Ding G, Wen G, Namba H, Xia Y*. Human Behavioral Assessments in Current Research of Parkinson’s Disease. Neuroscience& Biobehavioral Reviews 68: 741-772, 2016. Journal Impact Factor = 8.989 Zhou P, Chen Z, Liu X, Weng R, Liao J, Chen D, Xia Y*. Wang Q*. TLR4 signaling in MPP+-induced activation of BV2 cells. Neural Plasticity 2016: 5076740(9 pages), 2016. Journal Impact Factor = 3.599 Chao DM, Wang Q, Balboni G, Ding G, Xia Y*. Acupuncture-induced stabilization of K+ homeostasis in rat neonatal cortex exposed to hypoxic-ischemic stress. Molecular Neurobiology 53(10): 7213-7227, 2016. Journal Impact Factor = 5.590 Cao S, Chao DM, Zhou HH, Balboni G, Xia Y*. A novel mechanism for cytoprotection against hypoxic injury: DOR-mediated increase in Nrf2 translocation. British Journal of Pharmacology 172: 1869-1881, 2015. Journal Impact Factor = 8.740 Xu Y, Wei X, Liu X, Liao J, Lin J, Zhou P, Zhu C, Meng X, Xie D, Chao DM, Fenoy AJ, Cheng M, Tang B, Xia Y*, Wang Q*. Low cerebral glucose metabolism: A potential predictor for the severity of vascular parkinsonism and Parkinson’s disease. Aging and Disease 6: 426-436, 2015. Journal Impact Factor = 6.745 Jiang B, Shen RF, Bi J, Tian XS, Hinchliffe T, Xia Y*. Catalpol: A Potential Therapeutic for Neurodegenerative Diseases. Current Medicinal Chemistry 22: 1278-1291, 2015. Journal Impact Factor = 4.530 Gao H, Wei X, Liao J, Wang R, Xu J, Liu X, Pan X, Li Z, Li Z, Xia Y*, Wang Q*. Lower bone mineral density in Patients with Parkinson’s disease: a cross-sectional study from Chinese Mainland. Frontiers in Aging Neuroscience 7: 203, 2015. Journal Impact Factor = 5.750 Xu Y, Wei X, Liu X, Liao J, Lin J, Zhou P, Zhu C, Meng X, Xie D, Chao DM, Fenoy AJ, Cheng M, Tang B, Xia Y*, Wang Q*. Low cerebral glucose metabolism: A potential predictor for the severity of vascular parkinsonism and Parkinson’s disease. Aging and Disease 6: 426-436, 2015. Journal Impact Factor = 6.745 Liang JF, Chao DM, Sandhu HK, Balboni G, Kim DK, Xia Y*. δ-Opioid receptors up-regulate excitatory amino acid transporters of astrocytes in the mouse brain. British Journal of Pharmacology 171: 5417-5430, 2014. Journal Impact Factor = 8.740 Chen F, Qi ZF, Luo YM, Hinchliffe T, Ding GH, Xia Y*, Ji XM*. Non-pharmaceutical therapies for stroke: Mechanisms and clinical implications. Progress in Neurobiology 20: 191-201, 2014. Journal Impact Factor = 11.685 Chen T, Li J, Chao DM, Sandhu HK, Liao XP, Zhao JL, Wen GQ, Xia Y*. δ-Opioid receptor activation reduces ɑ-synuclein overexpression and oligomer formation induced by MPP+ and/or hypoxia. Experimental Neurology 255:127-136, 2014. Journal Impact Factor = 5.330 Fenoy AJ, Goetz L, Chabardès S, Xia Y*. Deep Brain Stimulation: Are Astrocytes a Key Driver Behind the Scene? CNS Neuroscience Therapeutics 20: 191-201, 2014. Journal Impact Factor = 5.243 Wang QY, Chao DM, Xia Y*. δ-opioid receptors and inflammatory cytokines in hypoxia: Differential regulation between neuron-like and glial cells. Translational Stroke Research 5: 476-483, 2014. Journal Impact Factor = 6.829 He XZ, Sandhu HK, Yang YL, Hua F, Belser N, Kim DH, Xia Y*. Neuroprotection against hypoxia/ischemia: δ-opioid receptor-mediated cellular/molecular event. Cellular and Molecular Life Sciences 70: 2291-2303, 2013. Journal Impact Factor = 9.261 Chao DM, Xia Y*. From Acupuncture to interaction between delta-opioid receptors and Na+ channels: A potential pathway to inhibit epileptic hyper-excitability. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 216016 (16 pages), 2013. Journal Impact Factor = 2.630 Zhou F, Guo JC, Cheng JS, Wu GC, Sun J, Xia Y*. Electroacupuncture and brain protection against cerebral ischemia: Specific effects of acupoints. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 804397 (14 pages), 2013. Journal Impact Factor = 2.630 Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y*. Effect of electroacupuncture on rat ischemic brain injury: Importance of stimulation duration. Evidence-Based Complementary and Alternative Medicine 2013: Article ID 878521 (12 pages), 2013. Journal Impact Factor = 2.630 Kang XZ, Shen XY, Xia Y*. Electroacupuncture-induced attenuation of experimental epilepsy: A comparative evaluation of acupoints and stimulation parameters. Evidence-Based Complementary and Alternative Medicine 2012: Article ID 149612, (10 pages), 2012. Journal Impact Factor = 2.630 Xu Y, Yan J, Zhou P, Li J, Gao H, Xia Y*, Wang Q*. Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease. Progress in Neurobiology 97(1): 1-13, 2012. Journal Impact Factor = 11.685 Yang YL, Zhi F, He XZ, Moore ML, Kang XZ, Chao DM, Wang R, Kim DH, Xia Y*. δ-Opioid receptor activation and microRNA expression of the rat cortex in hypoxia. Plos One 7(12): e51524, 2012. Journal Impact Factor = 3.240 Chao DM, He XZ, Yang YL, Bazzy-Asaad A, Lazarus LH, Balboni G, Kim DH, Xia Y*. DOR activation inhibits anoxic/ischemic Na+ influx through Na+ channels via PKC mechanisms in the cortex. Experimental Neurology 236 :228-239, 2012. Journal Impact Factor = 5.330 Feng Y, He XZ, Yang YL, Chao DM, Lazarus LH, and Xia Y*. Current research on opioid receptor function. Current Drug Targets 13: 230-246, 2012. Journal Impact Factor = 3.465 Kim JH, Song SY, Park SG, Song SU, Xia Y, Sung JH. Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem Cells. Stem Cells Dev 21: 2212-2221, 2012. Journal Impact Factor = 6.277 Chao DM, He XZ, Yang YL, Balboni G, Salvadori S, KimDH,Xia Y*. Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex. Toxicological Sciences 128(1): 198~208, 2012. Journal Impact Factor = 4.849 Park SG, Kim JH, Xia Y, Sung JH. Generation of reactive oxygen species in adipose derived stem cells: Friend or Foe? Expert Opinion on Therapeutic Targets, 15: 1297-1306, 2011. Journal Impact Factor = 6.902 Kim JH, Park SH, Park SG, Choi JS, Xia Y, Sung JK. The Pivotal Role of Reactive Oxygen Species Generation in the Hypoxia-Induced Stimulation of Adipose-Derived Stem Cells. Stem Cells and Development 20: 1753-1761, 2011. Journal Impact Factor = 3.272 Zhou F, Guo JC, Cheng JS, Wu GC, Xia Y*. Electroacupuncture increased cerebral blood flow and reduced ischemic brain injury: Dependence on stimulation intensity and frequency. Journal of Applied Physiology 111: 1877-1887, 2011. Journal Impact Factor = 3.532 Chao D, Xia Y*. Ionic storm in hypoxic/ischemic stress: Can opioid receptors subside it? Progress in Neurobiology 90: 439-470, 2010. Journal Impact Factor = 11.685 Kang XZ, Chao DM, Gu QB, Ding GH, Wang YW, Balboni G, Lazarus LH, and Xia Y*. Delta-opioid receptor activation decreases anoxic Na+ influx and K+ leakage via sodium channel regulation. Cellular and Molecular Life Sciences 66: 3505-3516, 2009. Journal Impact Factor = 9.261 Yang YL, Xia XW, Zhang Y, Wang Q, Li L, Luo GH, Xia Y*. Delta-opioid receptor activation attenuates oxidative injury in the ischemic rat brain. BMC Biology 7: 55, 2009. Journal Impact Factor = 7.431 Chao DM, Balboni G, Lazarus LH, Salvadori S, Xia Y*. Na+ mechanism of delta-opioid receptor induced protection from anoxic K+ leakage in the cortex. Cellular and Molecular Life Sciences 66:1105-1115, 2009. Journal Impact Factor = 9.261 Chao DM, Bazzy-Asaad A, Balboni G, Salvadori S, and Xia Y*. Activation of DOR attenuates anoxic K+ derangement via inhibition of Na+ entry in mouse cortex. Cerebral Cortex 18: 2217-2227, 2008. Journal Impact Factor = 5.357 Chao D, Donnelly D, Feng Y, Bazzy-Asaad A, Xia Y*. Cortical delta-opioid receptors potentiate K+ homeostasis during anoxia and oxygen-glucose deprivation. Journal of Cerebral Blood Flow and Metabolism 27: 356-368, 2007. Journal Impact Factor = 6.200 Chao DM, Bazzy-Asaad A, Gianfranco B, Xia Y*. Delta-, but not μ-, opioid receptor stabilizes K+ homeostasis by reducing Ca2+ influx in the cortex during acute hypoxia. Journal of Cellular Physiology 212: 60-67, 2007. Journal Impact Factor = 6.384 Zhang J, Qian H, Zhao P, Hong SS, Xia Y*. Rapid hypoxia preconditioning protects cortical neurons from glutamate toxicity through delta-Opioid Receptor. Stroke 37: 1094-1099, 2006. Journal Impact Factor = 7.914 Zhao P, Qian H, Xia Y*. GABA and glycine are protective to mature and toxic to immature in cortical neurons under hypoxia. European Journal of Neuroscience 22: 289-3000, 2005. Journal Impact Factor = 3.386 Ma MC, Qian H, Ghassemi F, Zhao P, Xia Y*. Oxygen sensitive delta-opioid receptor-regulated survival and death signals: Novel insights into neuronal preconditioning and protection. Journal of Biological Chemistry 280: 16208-16218, 2005. Journal Impact Factor = 5.157