王静欢 - 复旦大学 - 人类表型组研究院

个人简介

工作经历 2022-03 至今，在站博后，复旦大学 2021-07 至 2022-02，复旦大学，人类表型组研究院，助理研究员 2018.9-2021.6，复旦大学，药理学，博士 2017-07 至 2017-12，科伦药业，四川科伦研究院，助理研究员 2014.9-2017.6，西南大学，中药药理学，硕士 2010.9-2014.6，西南大学，药学，本科获奖情况复旦大学优秀党支部班级获复旦大学2019-2020学年优秀学生集体标兵党支部获复旦大学2019-2020学年示范党支部荣誉所参加的“新冠疫情，药你好看”案例宣传获案例大赛优秀案例奖复旦大学博士生优秀学业一、二等奖学金科研项目国家自然科学基金青年项目，82204386，靶向SNX13减轻神经元损伤在脑缺血中的作用及机制研究，2023.1-2025.12，30万元，在研，主持中国博士后科学基金委，2022TQ0080，靶向SNX13抑制AQP4治疗高原脑水肿的机制研究，2022-2024，18万元，在研，主持上海市科委生物医药领域科技支撑项目，22S11902700，治疗脑卒中的化药一类新药MT-8的临床前开发研究，2022.04-2025.03，40万元，在研，参加

研究领域

聚焦脑缺血疾病的表观遗传研究和药物新靶点的发现研究聚焦阿尔茨海默症、血管痴呆等神经退行性疾病的表观遗传研究和药物新靶点的发现研究聚焦高原急性脑水肿的机制研究和药物新靶点的发现聚焦高原慢性脑部病变的机制探讨和靶点研究聚焦高原慢性右心室肥大的机制探讨和靶点研究聚焦高原慢性血管功能改变的机制挖掘和靶点研究迄今，作为第一作者或共同第一作者身份已在Clinical and Translational Medicine（IF: 9.3686）、Aging and Disease（IF: 9.968）、Journal of the American Heart Association （IF: 5.501）、FASEB J（IF: 5.834）、ACS Medicinal Chemistry Letters（IF: 4.345）、Ann Transl Med（IF: 3.893；2篇）等国际知名学术期刊上发表SCI论文7篇，并参与发表SCI论文8篇；申请中国发明专利9项，其中授权专利1项，并申请PCT专利2项

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jinghuan Wang, Qianwen Cheng, Chen Hong, Jie Xu, Yuyu Zhang, Jiayao Liu, Xinhua Liu, Jun Chang. PARP16-mediated stabilization of amyloid precursor protein mRNA exacerbates Alzheimer’s disease pathogenesis. Aging and Disease. 2023. (期刊论文）(IF: 9.968) Jinghuan Wang, Jie Xu, Yejun Dong, Zhenghua Su, Haibi Su, Qianwen Cheng, Xinhua Liu. ADP-ribose transferase PARP16 mediated-unfolded protein response contributes to neuronal cell damage in cerebral ischemia/reperfusion. FASEB J. 2023.Feb;37(2):e22788. (期刊论文）(IF: 5.834) Jinghuan Wang, Wen Zhong, Qianwen Cheng, Chenxi Xiao, Jie Xu, Haibi Su, Xinhua Liu. Histone Methyltransferase Smyd2 Contributes to Blood-Brain Barrier Breakdown in Stroke. Clin Transl Med. 2022; doi: 10.1002/ctm2.761. （期刊论文）(IF: 9.3686) Mei-Lin Tang, Zi-Hao Wen, Jing-Huan Wang, Mei-Ling Wang, Heyanhao Zhang, Xin-Hua Liu, Lin Jin, Jun Chang, Discovery of Pyridone-substituted Triazolopyrimidine Dual A2A/A1 AR Antagonists for the Treatment of Ischemic Stroke. ACS Medicinal Chemistry Letters. 2022. (First co-author)（期刊论文）(IF: 4.345) Jinghuan Wang; Wen Zhong; Haibi Su; Jie Xu; Di Yang; Xinhua Liu; Yi Zhun Zhu, Histone methyltransferase Dot1L contributes to RIPK1 kinase-dependent apoptosis in cerebral ischemia/reperfusion. Journal of the American Heart Association (JAHA). 2021.12.7, 10(23): e022791. （期刊论文）(IF: 5.501) Jinghuan Wang; Dong Wan; Guoran Wan; Jianghong Wang; Junhui Zhang; Huifeng Zhu, Catalpol induces cell activity to promote axonal regeneration via the PI3K/AKT/mTOR pathway in vivo and in vitro stroke model. Ann Transl Med. 2019.7 (23): 756. （期刊论文）(IF: 3.893) Huifeng Zhu; Jinghuan Wang; Yali Shao; Dong Wan, Catalpol may improve axonal growth via regulating miR-124 regulated PI3K/AKT/mTOR pathway in neurons after ischemia. Ann Transl Med. 2019.7 (14): 306. (First co-author)（期刊论文） (IF: 3.893) 王静欢, 张志敏, 邱炳勋, 万东, 祝慧凤. 两种原代培养方法对新生大鼠大脑皮质神经元生物学特性的影响[J].西南大学学报(自然科学版), 2018, (2): 19-26. 王静欢, 刘珂, 万东, 祝慧凤. 梓醇对大脑皮质神经元的抗衰老保护作用研究[J].中国药理学通报,2017, (12): 1691-1697. 王静欢，邹利，万东等. 梓醇多效性相关信号通路研究进展[J].中国药理学通报, 2015, (9): 1189-1194. Weijun Wu; Jinghuan Wang; Qin Wang; Haibi Su; Wen Zhong; Jianchun Mao; Xinhua Liu; Yi Zhun Zhu, SMYD2-mediated TRAF2 methylation promotes the NF-κB signaling pathways in inflammatory diseases. Clinical and Translational Medicine. 2021.11, 11(11): e591. （期刊论文）(IF: 11.492) Fen Long; Di Yang; Jinghuan Wang; Qing Wang; Ting Ni; Gang Wei; Yizhun Zhu; Xinhua Liu，SMYD3–PARP16 axis accelerates unfolded protein response and mediates neointima formation. Acta Pharmaceutica Sinica B. 2020.5, 11(5): 1261-1273. （期刊论文） (IF: 11.413) Huifeng Zhu; Lei Qin; Jinghuan Wang; Shan Feng; Dong Wan, Catalpol enhances neurogenesis in the SVZ in a rat model of strokes. Int J Clin Exp Med. 2019; 12(7): 8068-8077. （期刊论文） Huifeng Zhu; Yali Shao; Lei Qin; Jinghuan Wang; Shan Feng; Yunbin Jiang; Dong Wan, Catalpol Enhances Neurogenesis And Inhibits Apoptosis Of New Neurons Via BDNF, But Not The BDNF/Trkb Pathway. Drug Des Devel Ther. 2019, 12,10;13:4145-4157. （期刊论文） (IF: 4.162) Mengwei Huang; Qing Wang; Fen Long; Di Yang; Jinghuan Wang; Yi Zhun Zhu; Xinhua Liu, Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice. Faseb J. 2020.5; 34(3): 4107-4119. （期刊论文） (IF: 5.191) Fen Long; Qing Wang; Di Yang; Menglin Zhu; Jinghuan Wang; Yi Zhun Zhu; Xinhua Liu, Targeting JMJD3 histone demethylase mediates cardiac fibrosis and cardiac function following myocardial infarction. Biochem Biophys Res Commun. 2020. 8, 6; 528(4): 671-677. （期刊论文） (IF: 4.6) Huifeng Zhu; Yuan Wang; Zhiqiang Liu; Jinghuan Wang; Dong Wan; Shan Feng; Xian Yang; Tao Wang, Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed. Chinese Medicine. 2016.5,11; 11:25. （期刊论文）(IF: 5.455) Wan Dong; Yang Xian; Wang Yuan; Zhu Huifeng; Wang Tao; Liu Zhiqiang; Feng Shan; Fu Ya; Wang Hongli; Wang Jinghuan; Qin Lei; Zou Li; Qi Hongyi, Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats’ stroke model. Journal of Ethnopharmacology. 2016. 9,15; 191:169-179. （期刊论文） (IF: 4.36)