余孟瑶 - 复旦大学 - 人类表型组研究院

个人简介

工作经历 2022.08-至今，复旦大学人类表型组研究院，青年研究员 2020.11-2022.07，中国科学院脑科学与智能技术卓越创新中心，生物信息工程师 2019.09-2020.09，斯坦福大学医学院，博士后 2015.10-2019.06，巴黎索邦西岱大学（巴黎第五大学），遗传学，博士

研究领域

使用多组学手段研究心脏瓣膜病的遗传学机制研究复杂环境对心血管疾病的影响复杂疾病的多基因风险评估

近期论文

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Mengyao Yu, Catherine Tcheandjieu, Adrien Georges, et.al., Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease. JCI Insight. 2022;7(3):e146580. Carolina Roselli, Mengyao Yu, Victor Nauffal, et.al., Genome-wide Association Study reveals Novel Genetic Loci and Polygenic Risk Score for Mitral Valve Prolapse. Eur Heart J. 2022 May 1;43(17):1668-1680. Mengyao Yu, Sergiy Kyryachenko, Stephanie Debette, et.al., Genome-wide association meta-analysis supports genes involved in valve and cardiac development to associate with mitral valve prolapse. Circ Genom Precis Med. 2021 Aug 31:CIRCGEN120003148. Sergiy Kyryachenko*, Adrien Georges*, Mengyao Yu*, et.al., Chromatin Accessibility of Human Mitral Valves and Functional Assessment of MVP Risk Loci. Circ Res. 2021 Mar 5;128(5):e84-e101. Hafid Ait-Oufella*, Mengyao Yu*, Adrien Georges, et. al., Plasma and genetic determinants of soluble TREM-1 and major adverse cardiovascular events in a prospective cohort of acute myocardial infarction patients. Results from the FAST-MI 2010 study. Int J Cardiol. 2021 Dec 1;344:213-219. Catherine Tcheandjieu, Daniela Zanetti, Mengyao Yu, James Priest. Inherited extremes of aortic diameter confer risk for a specific class of congenital heart disease. Circ Genom Precis Med. 2020 Dec;13(6):e003170. Mengyao Yu, Adrien Georges, Nathan R. Tucker, et.al., Genome-Wide Association Study-Driven Gene-Set Analyses, Genetic, and Functional Follow-Up Suggest GLIS1 as a Susceptibility Gene for Mitral Valve Prolapse. Circ Genom Precis Med. 2019 May;12(5):e002497. Katelynn Toomer*, Mengyao Yu*, Diana Fulmer*, et.al., Primary cilia defects causing mitral valve prolapse. Sci Transl Med. 2019 May 22;11(493). Mengyao Yu, Andrew R. Harper, Matthew Aguirre, et al., "Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy." Circ Genom Precis Med. 2023 Apr 5:e003708. Mengyao Yu, Matthew Aguirre, Meiwen Jia, et al., "Oligogenic Architecture of Rare Noncoding Variants Distinguishes 4 Congenital Heart Disease Phenotypes." Circ Genom Precis Med. 2023 Apr 7:e003968