吴浩 - 复旦大学 - 人类表型组研究院

个人简介

工作经历 2002-2005，山东理工大学生命科学学院，获工学学士学位 2007-2012，浙江大学沃森基因研究院，获理学博士学位 2012-2014，中国科学院北京基因组研究所，助理研究员 2015-2020，瑞典哥德堡大学Sahlgrenska医院，博士后 2021-至今，复旦大学人类表型组研究院，青年研究员

研究领域

肠道内生态紊乱与肠道菌失衡肠道菌与糖尿病、心血管疾病等代谢性疾病之间的因果关系研究肠道菌对药物及饮食干预的影响多组学数据整合细菌基因组突变与进化研究

近期论文

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Hao Wu*, Valentina Tremaroli*, Caroline Schmidt, Annika Lundqvist, Lisa M Olsson, Manuela Kr?mer, Anders Gummesson, Rosie Perkins, G?ran Bergstr?m#, Fredrik B?ckhed#. The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study. 2020. Cell Metabolism 32 (3), 379-390. e3 Ara Koh, Antonio Molinaro, Marcus St?hlman, Muhammad Tanweer Khan, Caroline Schmidt, Louise Manner?s-Holm, Hao Wu, Alba Carreras, Heeyoon Jeong, Louise E Olofsson, Per-Olof Bergh, Victor Gerdes, Annick Hartstra, Maurits de Brauw, Rosie Perkins, Max Nieuwdorp, G?ran Bergstr?m, Fredrik B?ckhed#. Microbially produced imidazole propionate impairs insulin signaling through mTORC1. 2018. Cell 175 (4), 947-961. e17 Adil Mardinoglu*, Hao Wu*, Elias Bjornson, Cheng Zhang, Antti Hakkarainen, Sari M R?s?nen, Sunjae Lee, Rosellina M Mancina, Mattias Bergentall, Kirsi H Pietil?inen, Sanni S?derlund, Niina Matikainen, Marcus St?hlman, Per-Olof Bergh, Martin Adiels, Brian D Piening, Marit Granér, Nina Lundbom, Kevin J Williams, Stefano Romeo, Jens Nielsen, Michael Snyder, Mathias Uhlén, G?ran Bergstr?m, Rosie Perkins, Hanns-Ulrich Marschall, Fredrik B?ckhed#, Marja-Riitta Taskinen, Jan Borén#. An integrated understanding of the rapid metabolic benefits of a carbohydrate-restricted diet on hepatic steatosis in humans. 2018. Cell metabolism 27 (3), 559-571. e5 Hao Wu*, Eduardo Esteve*, Valentina Tremaroli, Muhammad Tanweer Khan, Robert Caesar, Louise Manner?s-Holm, Marcus St?hlman, Lisa M Olsson, Matteo Serino, Mercè Planas-Fèlix, Gemma Xifra, Josep M Mercader, David Torrents, Rémy Burcelin, Wifredo Ricart, Rosie Perkins, José Manuel Fernàndez-Real#, Fredrik B?ckhed#. Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug. 2017. Nature medicine 23 (7), 850 Hao Wu*, Valentina Tremaroli*, Fredrik B?ckhed#. Linking microbiota to human diseases: a systems biology perspective. 2015. Trends in Endocrinology & Metabolism 26 (12), 758-770 Hao Wu, Yongjun Fang, Jun Yu#, Zhang Zhang#. The quest for a unified view of bacterial land colonization. 2014. The ISME journal 8 (7), 1358-1369