杨迪 - 复旦大学 - 人类表型组研究院

个人简介

工作经历 2022.12 – 至今，复旦大学人类表型组研究院，副研究员 2020.06 – 2022.12，复旦大学人类表型组研究院，青年副研究员 2018.06 - 2020.06，复旦大学基础医学院，基础医学，博士后 2015.09 - 2018.06，复旦大学药学院，药理学，博士获奖情况入选博新计划获上海市超级博士后激励计划资助任中国药理学会心血管药理专业委员会第二届青年委员会委员

研究领域

心血管与代谢药理学、药物表型组学。具体研究内容包括： 1. 聚焦心血管与代谢性疾病表型，探索疾病发生的新靶点和新机制：探索临床重要心血管与代谢性疾病如主动脉瘤/夹层、高血压、心肌肥大/心衰、肥胖等疾病发生的新靶点和新机制 2. 聚焦“心血管-脂肪轴”，探索细胞/器官/疾病互作的分子机理和关键靶点：探索心/血管和脂肪细胞/器官之间的交流互作模式，阐明心血管疾病与代谢性疾病表型交联对话的分子机理和关键靶点 3. 药物研发：针对有前景的靶点展开药物筛选/评价，积极推动成果转化

近期论文

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Haibi Su, Chen Meng, Jie Xu, Zhenghua Su, Chenxi Xiao, Di Yang*. Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation. Cell Death & Disease. 2022 Oct 21;13(10):890. Haibi Su, Jie Xu, Zhenghua Su, Chenxi Xiao, Jinghuan Wang, Wen Zhong, Chen Meng, Di Yang*, Yizhun Zhu*. Poly (ADP-ribose) polymerases 16 triggers pathological cardiac hypertrophy via activating IRE1α-sXBP1-GATA4 pathway. Cellular and Molecular Life Sciences. 2023 May 23;80(6):161. Zhenghua Su, Haibi Su, Jie Xu, Gang Wei, Lefeng Qu, Ting Ni*, Di Yang*, Yi Zhun Zhu*. Histone methyltransferase Smyd2 drives vascular aging by its enhancer-dependent activity. Aging (Albany NY). 2022 Dec 28;15(1):70-91. Di Yang#, Peng Xu#, Haibi Su, Wen Zhong, Jie Xu, Zhenghua Su, Xinhua Liu. The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis. Cell Death & Disease. 2022 Jan 17;13(1):60. Di Yang, Fen Long, Gang Wei, Zhenghua Su, Ting Ni, Xinhua Liu, Yi Zhun Zhu. H3K4 methyltransferase Smyd3 mediates vascular smooth muscle cell proliferation, migration and neointima formation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2021 Jun;41(6):1901-1914. Di Yang, Gang Wei, Fen Long, Hongbo Nie, Xiaoli Tian, Lefeng Qu, Jinfeng Hu, Wanjin Hong, ShuangXi Wang, Peng Li, Yue Qiu, Yang Wang, Ting Ni, Xinhua Liu, Yi Zhun Zhu. Histone methyltransferase Smyd3 is a new regulator for vascular senescence. Aging Cell. 2020 Aug 11;19(9):e13212. Di Yang, Qing Wang, Gang Wei, Jiaxue Wu, Yi Chun Zhu, Qing Zhu, Ting Ni, Xinhua Liu, Yi Zhun Zhu. Smyd3-PARP16 axis accelerates unfolded protein response and vascular senescence. Aging (Albany NY). 2020 Nov 3;12(21):21423-21445. Di Yang, ChenXi Xiao, Fen Long, ZhengHua Su, WanWan Jia, Ming Qin, MengWei Huang, WeiJun Wu, XinHua Liu, YiZhun Zhu. HDAC4 regulates vascular inflammation via activation of autophagy. Cardiovascular Research. 2018 Jun 1;114(7):1016-1028. Xiao-Ling Luo#, Di Yang#, Wei-Jun Wu, Si-Yu Liu, Peng Xu, Wan-Wan Jia, Ming Qin, Betty Yuen-Kwan Law, Le-Feng Qu, Xin-Hua Liu, Yi Zhun Zhu. Critical role of histone demethylase JMJD3 in the regulation of neointima formation following vascular injury. Cardiovascular Research. 2018 Dec 1;114(14):1894-1906. Di Yang, ChenXi Xiao, Fen Long, WeiJun Wu, MengWei Huang, LeFeng Qu, XinHua Liu, YiZhun Zhu. Fra-1 plays a critical role in angiotensin II-induced vascular senescence. FASEB Journal. 2019 Jun;33(6):7603-7614. Di Yang, Chen-Xi Xiao, Zheng-Hua Su, Meng-Wei Huang, Ming Qin, Wei-Jun Wu, Wan-Wan Jia, Yi-Zhun Zhu, Jin-Feng Hu, Xin-Hua Liu. (-)-7(S)-hydroxymatairesinol protects against tumor necrosis factor-α-mediated inflammation response in endothelial cells by blocking the MAPK/NF-κB and activating Nrf2/HO-1. Phytomedicine. 2017 Aug 15;32:15-23.