当前位置: X-MOL首页全球导师 国内导师 › 钱斌治

个人简介

教育经历 2002年-2009年 博士 美国爱因斯坦医学院 生物医学(导师Jeffery Pollard) 1995年-1999年 学士 复旦大学 生物化学 科研与学术工作经历 2023年-至今 复旦大学人类表型组研究院,特聘教授(二级),博士生导师 2017年-至今 英国爱丁堡大学癌症研究中心和生殖健康中心,终身教授(Reader, tenured),博士生导师 2013年-2018年 英国爱丁堡大学癌症研究中心和生殖健康中心,校监特聘首席研究员 2018年-2021年 广东省珠江学者讲座教授(广州医科大学) 2017年-2020年 广州医科大学附属第二医院转化医学中心,南山学者特聘客座教授,博士生导师 2015年-2018年 第二军医大学,客座教授 2012年-2014年 美国纪念斯隆-凯特琳癌症中心,副研究员(合作导师:Charles Sawyers) 2009年-2013年 美国爱因斯坦医学院发育分子生物学专业,博士后副研究员 1999年-2002年 中国人类基因组南方研究中心,助理研究员 学术奖励 2015年 爱丁堡大学学院早期成就奖 2014年 英国癌症研究职业发展奖 2013年 Movember-Prostate Cancer Foundation 挑战奖 2013年 Dennis Shields纪念基金研究奖: 最佳博士后研究奖 2012年 Susan G. Komen for the Cure 博士后奖 2012年 美国癌症研究协会在训学者奖(103期) 2011年 美国癌症研究协会在训学者奖(102期)

研究领域

空间组学;肿瘤免疫;肿瘤微环境;生物信息学

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Salem O, Jia S, Qian BZ, Hansen CG. AR activates YAP/TAZ differentially in prostate cancer. Life Sci Alliance. 2023;6(9):e202201620. doi:10.26508/lsa.202201620 Yang Y, Chen Y, Pei P, Fan Y, Wang S, Zhang H, Zhao D, Qian BZ, Zhang F. Fluorescence-amplified nanocrystals in the second near-infrared window for in vivo real-time dynamic multiplexed imaging. Nat Nanotechnol. 2023 Jun 22. doi: 10.1038/s41565-023-01422-2. Li XF, Selli C, Zhou H, Cao J, Wu S, Ma RY, Lu Y, Zhang CB, Xun B, Lam AD, Pang XC, Fernando A, Zhang Z, Unciti-Broceta A, Carragher NO, Ramachandran P, Henderson NC, Sun LL, Hu HY, Li GB, Sawyers C, Qian BZ. Macrophages promote anti-androgen resistance of prostate cancer bone disease. J Exp Med. 2023 Apr 3;220(4):e20221007. doi: 10.1084/jem.20221007. Edwards-Hicks J, Su H, Mangolini M, Yoneten KK, Wills J, Rodriguez-Blanco G, Young C, Cho K, Barker H, Muir M, Guerrieri AN, Li XF, White R, Manasterski P, Mandrou E, Wills K, Chen J, Abraham E, Sateri K, Qian BZ; Bankhead P, Arends M, Gammoh N, von Kriegsheim, A, Patti GJ, Sims AH; Acosta JC, Brunton V, Kranc, KR, Christophorou M, Pearce EL, Ringshausen I, Finch, AJ. MYC sensitises cells to apoptosis by driving energetic demand. Nature Communications. 2022, 13 (1), 4674. DOI 10.1038/s41467-022-32368-z. Rodriguez-Tirado C, Entenberg D, Li J, Qian BZ, Condeelis JS, Pollard JW. Interleukin 4 controls the role of macrophages in pulmonary metastatic tumor cell seeding and growth in mice. Cancers. 2022 Sep 5;14(17):4336. doi: 10.3390/cancers14174336. Ma RY; Black A; Qian BZ. Macrophage diversity in cancer revisited in the era of single-cell omics. Trends Immunol. 2022 Jul;43(7):546-563. DOI: 10.1016/j.it.2022.04.008 Wu N, Aquilina M, Qian BZ, Loos R, Gonzalez-Garcia I, Santini CC, Dunn K The application of nanotechnology for quantification of circulating tumour DNA in liquid biopsies: a systematic review. IEEE Rev Biomed Eng. 2022; DOI: 10.1109/RBME.2022.3159389 Wang C, Hong J, Yang Z, Zhou X, Yang Y, Kong Y, Chen B, Wu H, Qian BZ, Dimitrov DS, Zhou X, Wu Y, and Ying T. Design of a Novel Fab-Like Antibody Fragment with Enhanced Stability and Affinity for Clinical Use. Small Methods. 2021, 2100966 DOI: 10.1002/smtd.202100966 Pang X, Zhang J, He X, Gu Y, Qian BZ, Xie R, Yu W, Zhang X, Li T, Shi X, Zhou Y, and Cui Y. SPP1 Promotes Enzalutamide Resistance and Epithelial-Mesenchymal-Transition Activation in Castration-Resistant Prostate Cancer via PI3K/AKT and ERK1/2 Pathways. Oxidative Medicine and Cellular Longevity, vol. 2021, Article ID 5806602, 2021. Temps C, Lietha D, Webb E, Li XF, Dawson JC, Muir M, Contreras-Montoya R, Macleod KG, Valero T, Luque-Ortega JR, Fraser C, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability. Cancer Research. 2021 2021 Nov 1;81(21):5438-5450. Crittenden S, Goepp M, Pollock J, Robb CT, Smyth DJ, Zhou Y, Andrews R, Tyrrell V, Gkikas K, Adima A, O’Connor RA, Davies L, Li XF, Yao HX, Ho GZ, Zheng X, Mair A, Sonja Vermeren S, Qian BZ, Mole DJ, Gerasimidis K, Schwarze JKJ, Breyer RM, Arends MJ, O’Donnell VB, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Rossi AG, Howie SE, Yao C. Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells. Science advances. 2021 Feb 1; 7 (7) eabd7954 Zhou Y, Yang D, Yang QC, Lv XB, Huang WT, Zhou Z, Wang YL, Ding X, Tang LN, Zhang JJ, Yin JY, Huang YJ, Yu WX, Wang YG, Chen- Zhou L, Su Y, Guo-Wei Qian, He AN, Sun YJ, Shen Z, Qian BZ, Chen PZ, Yao Y, Hu HY. Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. Nat Com. 2020 Dec 10;11(1):6322. Ma RY, Zhang H, Li XF, Zhang CB, Selli C, Tagliavini G, Prost S, Sims AH, Hu HY, Ying T, Wang Z, Ye Z, Pollard JW, Qian BZ. Monocyte-derived macrophages promote breast cancer bone metastasis outgrowth. J Exp Med. 2020, 217 (11): e20191820 Subiros-Funosas, R., Ho, V.C.L., Barth, N., Mendive-Tapia, L., Pappalardo, M., Barril, X., Ma, R., Zhang, C., Qian BZ., Sintes, M. and Ghashghaei, O., 2020. Fluorogenic Trp (redBODIPY) Cyclopeptide Targeting Keratin 1 for Imaging of Aggressive Carcinomas. Chemical Science. 2020,11, 1368-1374 Pang, X, Gong, K, Zhang, X, Wu, S, Cui, Y, and Qian BZ (2019). Osteopontin as a multifaceted driver of bone metastasis and drug resistance. Pharmacol. Res. 144, 235-244. Wu SQ, Xu R, Li XF, Zhao X, Qian BZ Prognostic roles of tumor associated macrophages in bladder cancer: a system review and meta-analysis. Oncotarget. 2018 May 18;9(38):25294-25303 Graham N, Qian BZ. Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis. Int. J. Mol. Sci. 2018, 19(4), 1121; doi:10.3390/ijms19041121 Gómez-Cuadrado L, Tracey N, Ma R, Qian BZ, Brunton VG Mouse models of metastasis: progress and prospects. Disease Models and Mechanisms. 2017 Sep 1;10(9):1061-1074. doi: 10.1242/dmm.030403. Qian BZ. Inflammation fires up cancer metastasis. Seminars in Cancer Biology. 2017 Aug 31. pii: S1044-579X(17)30210-9. doi: 10.1016/j.semcancer.2017.08.006 Cao J, Liu J, Xu R, Zhu X, Zhao X, Qian BZ. Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: A systematic review and meta-analysis. Oncotarget. 2017 Jun 27; : 1–9. doi: 10.18632/oncotarget.18743. Qin W, Zheng Y, Qian BZ#, Zhao M# Prostate cancer stem cells and nanotechnology: a focus on Wnt signaling. Front. Pharmacol. 2017 Mar 28; 8: 153 (# co-corresponding author) Hughes R*, Qian BZ* Muthana M, Keklikoglou I, Olson OC, Tazzyman S, Danson S, Addison C, Clemons M, Gonzalez-Angulo AM, Joyce JA, De Palma M, Pollard JW and Lewis CE. Perivascular M2 macrophages Stimulate Tumor Relapse After Chemotherapy. Cancer Research. 2015 Sep 1;75(17):3479-91 (co-first author) Qian BZ#, Zhang H, Li J, He AT, Yeo EJ, Soong DYH, Carragher N, Munro A, Chang A, Bresnick AR, Lang RA and Pollard JW# FLT1 signaling in metastasis-associated macrophages activates an inflammatory signature that promotes breast cancer metastasis. J Exp Med 2015 Aug 24; 212(9):1433-48. (# co-corresponding author) Harney AS, Arwert EN, Entenberg D, Wang Y, Qian BZ, Pollard JW, Jones JG and Condeelis JS. Real-time imaging reveals local, transient vascular permeability and tumor cell intravasation by Tie2Hi macrophage-derived VEGFA. Cancer Discov 2015 Sep;5(9):932-43. Kitamura T, Qian BZ, Soogn D, Cassetta L, Noy R, Sugano G, Kato Y, Li J and Pollard JW CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages. J Exp Med 2015 Jun 29;212(7):1043-59. Kitamura T, Qian BZ and Pollard JW Immune cell promotion of metastasis. Nature Review Immunology 2015 Feb. 2: 73-86. Yeo EJ*, Cassetta L*, Qian BZ*, Lewkowich I, Li JF, Stefater JA 3rd, Smith AN, Wiechmann LS, Wang Y, Pollard J, Lang RA. Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer. Cancer Research. 2014 Jun 1; 74 (11):2962-73. (co-first author) Kim S, Yao J, Suyama K, Qian X, Qian BZ, Bandyopadhyay S, Loudig OD, De Leon-Rodriguez C, Zhou ZN, Segall JE, Macian F, Norton L, Hazan RB. Slug Promotes Survival during Metastasis through Suppression of Puma-mediated Apoptosis. Cancer Res. 2014 May 29; 74: 3695-3706 Qian BZ, Pollard JW. New trick for metastasis associated macrophages. Breast Cancer Research. 14:316 July 19, 2012. Boimel P, Smirnova T, Zhou ZN, Wyckoff J, Park H, Coniglio SJ, Patel P, Qian BZ, Stanley ER, Bresnick AR, Cox D, Pollard JW, Muller WJ, Condeelis J, Segall JE Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Research. 2012 Feb 7;14(1):R23. Qian BZ, Li J, Zhang H, Kitamura T, Campion LR, Kaiser EA, Zhang J, Snyder LA and Pollard JW. CCL2 recruits inflammatory monocytes to facilitate breast tumor metastasis. Nature. 475, 222-25 July 14, 2011. Qian BZ, Pollard JW. Macrophage Diversity Enhances Tumor Progression and Metastasis. Cell. 141, 39-51 April 2, 2010 Qian BZ, Deng Y, Im JH, Muschel RJ, Zou Y, et al. 2009. A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth. PLoS ONE. 4(8): e6562. Landskroner-Eiger S, Qian BZ, Muise E, Nawrocki A, Berger J, Fine E, Koba W, Deng Y, Pollard JW, Scherer P. Proangiogenic Contribution of Adiponectin Towards Mammary Tumor Growth in vivo. Clinical Cancer Research. 15, 3265, May 15, 2009. Agiostratidou G, Li M, Suyama K, Badano I, Keren R, Chung S, Anzovino A, Hulit J, Qian BZ, Bouzahzah B, et al. Loss of Retinal Cadherin Facilitates Mammary Tumor Progression and Metastasis. Cancer Research. 69, 5030, June 15, 2009. Du JJ, Dou KF, Peng SY, Qian BZ, Xiao HS, Liu F, et al. Expression of NGF family and their receptors in gastric carcinoma a cDNA microarray study. World J Gastroenterol. 2003 Jul.; 9(7):1431-4. Xu X, Huang J, Xu Z, Qian BZ, Zhu Z, Yan Q, Cai T, Zhang X, Xiao H, et al: Insight into hepato- cellular carcinoma at transcriptome level by comparing gene expression profiles between HCC and those of corresponding non-cancerous liver. Proc. Natl. Acad. Sci. USA, 2001, Dec.18; 98 (26) : 15089-94 Qian Y, Qian BZ, Su B, Chu Z, Ke Y, Yu J, Shi L, Chu J, Lu D and Jin L: Multiple Origins of Tibetan Y Chromosomes. Hum Genet. 2000; 106:453-454. Li H, Zhang W, Qian BZ, Shen Y, Chen Y and Hu Y: A Dermatoglyphic Study on Lahu-na Population. Journal of Fudan University (Natural Science). 38 (Oct. 1999) 5, 517-522

学术兼职

2017年 《Clinical and Experimental Metastasis》编委 2016年 英国牛顿国际基金评委 2015年 2015年本科生奖生命科学组评委 2015年 《Scientific Reports》编委 2012年 学术刊物及专著审稿人,包括Nature, Nature Cell Biology, Science Translation Medicine, Immunity, Cancer Cell, Journal of Experimental Medicine, eLife, Cancer Research, PLoS Biology

推荐链接
down
wechat
bug