徐薇 - 复旦大学 - 生物医学研究院

个人简介

工作经历研究员复旦大学，生物医学研究院（2021.1-至今）副研究员复旦大学，生物医学研究院（2017.1-2021.1）助理研究员复旦大学，生物医学研究院（2011.7-2016.12）教育经历博士复旦大学生物医学研究院（2006.9-2011.7）学士浙江大学生命科学学院（2002.9-2006.7）所获人才项目上海市青年科技启明星计划项目 (2018) 上海市卫生计生系统优秀青年医学人才培养计划（2018）中国科协首届“青年人才托举工程”（2015）所获奖项中华医学科技奖二等奖，第二完成人（2017）上海市医学科技奖二等奖，第二完成人 (2016) 教育部自然科学一等奖，第七完成人（2012）

研究领域

一直从事代谢物失调与疾病发生机制研究，从代谢物失调角度研究肿瘤、糖尿病等疾病的发生原因。在代谢物感知与代谢物信号传导分子机制的相关研究，以及代谢网络的乙酰化调控研究中取得了系列进展。未来将以氨基酸信号感知为重点，将氨基酰化修饰结合到肿瘤、糖尿病等重大疾病发生分子机制的研究中，深入解析氨基酸信号失调与疾病发生的相关性。

近期论文

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Zhang, J.-J., Fan, T.-T., Mao, Y.-Z., Hou, J.-L., Wang, M., Zhang, M., Lin, Y., Zhang, L., Yan, G.-Q., An, Y.-P., Yao, J., Zhang, C., Lin, P.-C., Yuan, Y.-Y., Zhao, J.-Y., Wei Xu#, and Zhao, S.-M.* (2021) Nuclear dihydroxyacetone phosphate signals nutrient sufficiency and cell cycle phase to global histone acetylation. Nature Metabolism Xin-Yu Mei*, Da-Shi Qi*, Ting Zhang*, Yin Zhao*, Li Jin, Junli Hou, Jianhua Wang, Yan Lin, Yu Xue, Pingping Zhu, Zexian Liu, Lei Huang, Ji Nie, Wen Si, Jingyi Ma, Jianhong Ye, Richard H. Finnell, Hexige Saiyin, Hong-Yan Wang#, Jian-Yuan Zhao#, Shi-Min Zhao#, and Wei Xu#. Inhibiting Methionyl-tRNA synthetase reduces neural tube defects and congenital heart defects onsets. EMBO Molecular Medicine.（2020） Xia-Di He, Wei Gong, Jia-Nong Zhang, Ji Nie, Cui-Fang Yao, Fu-Shen Guo, Yan Lin, Xiao-Hui Wu, Feng Li, Jie Li, Wei-Cheng Sun, En-Duo Wang, Yan-Peng An, Hui-Ru Tang, Guo-Quan Yan, Peng-Yuan Yang, Yun Wei, Yun-Zi Mao, Peng-Cheng Lin, Jian-Yuan Zhao, Yan-Hui Xu#, Wei Xu#, Shi-Min Zhao# Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations. Cell Metabolism 27（2018）151-166. Feng Li*, Xiadi He*, Dingwei Ye*, Yan Lin, Hongxiu Yu, Cuifang Yao, Lei Huang, Jianong Zhang, Fang Wang, Sha Xu, Xiaohui Wu, Lixia Liu, Chen Yang, Jiaqi Shi, Xiaoyang He, Jie Liu, Yuanyuan Qu, Fushen Guo, Jianyuan Zhao, Wei Xu#, and Shimin Zhao# NADP+-IDH mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance. Molecular Cell. 60 (2015), 661-675 Ya-Kun Zhang*, Yuan-Yuan Qu*, Yan Lin*, Xiao-Hui Wu, Hou-Zao Chen, Xu Wang, Kai-Qiang Zhou, Yun Wei, Fushen Guo, Cui-Fang Yao, Xia-Di He, Li-Xia Liu, Chen Yang, Zong-Yuan Guan, Shi-Dong Wang, Jianyuan Zhao, De-Pei Liu#, Shi-Min Zhao#, and Wei Xu# Enoyl-CoA Hydratase-1 Regulates mTOR Signaling and Apoptosis by Sensing Nutrients. Nature Communications 8,464,(2017). He, Chang-Liang*，Yang-Yang Bian*，Yu Xue，Ze-Xian Liu，Kai-Qiang Zhou，Cui-Fang Yao， Yan Lin，Han-Fa Zou，Fang-Xiu Luo，Yuan-Yuan Qu，Jian-Yuan Zhao， Ming-Liang Ye，Shi-Min Zhao and Wei Xu#, Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1. Sci Rep 6, 21524, (2016). Xu, W., Li, Y., Liu, C. & Zhao, S. Protein lysine acetylation guards metabolic homeostasis to fight against cancer. Oncogene 33(2014), 2279-2285. Xu W* , Hui Yang*, Ying Liu*, Ying Yang, Ping Wang, Se-Hee Kim, Shinsuke Ito, Chen Yang, Pu Wang, Meng-Tao Xiao, Li-xia Liu, Wen-qing Jiang, Jing Liu, Jin-ye Zhang, Bin Wang, Stephen Frye, Yi Zhang, Yan-hui Xu,Qun-ying Lei, Kun-Liang Guan#, Shi-min Zhao#, and Yue Xiong#. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell19(1) (2010),17-30. Zhao, S-M., Xu, W. *, Jiang, W-Q. *, Yu, W., Lin, Y., Zhang, T-F., Yao, J., Zhou, L., Zeng, Y., Li, H., Li, Y., Shi, J., An, W-L., Hancock, S. M., He, F., Qin, L-X., Chin, J. C., Yang, P-Y., Chen, X., Lei, Q-Y., Xiong, Y. # and Guan, K-L. # Regulation of cellular metabolism by protein lysine acetylation. Science 327 (2010),1000-1004. Zhao, S-M., Li, Y.*, Xu, W. *, Jiang, W-Q. *, Zha, Z-Y., Yu, W., Li, Z-Q., Gong, L-L., Peng, Y-J., Ding, J-P., Lei, Q-Y., Guan, K-L.#, and Xiong, Y. # Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1α. Science 324(2009),261-265.