陈海威 - 复旦大学 - 生物医学研究院

个人简介

工作经历青年研究员，复旦大学，生物医学研究院 (2022.09-今) 副研究员，耶鲁大学，免疫学系（2018.11-2022.07）博士后，耶鲁大学，免疫学系（2016.04-2018.10）教育经历博士，北京大学，生命科学学院（2010.09-2016.01）本科，中山大学，生命科学学院（2006.09-2010.07）所获奖项 The Trudeau Trainee Research Fellowship，耶鲁大学免疫学系，2018

研究领域

课题组通过技术创新，来系统性研究人体生理学（“人体如何维持正常生理”）和病理学（“疾病是如何发生”）。我们基于下一代基因测序来开发一系列功能性高通量筛选体系，用于人体和微生物代谢物的功能性研究；孤儿GPCR内源性配体的鉴定和功能性研究；现代中药系统化工程等领域。已发表SCI论文十余篇，包括Cell，Scientific Report等；研究成果共申请专利1项(美国专利一项)，已完成转化。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Chen H, Rosen CE, Gonzalez-Hernandez JA, Ring AM, Palm NW. Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions. Cell (under revision) Yang Y, Nguyen M, Khetrapal V, Sonnert ND, Martin AL, Chen H, Martin AK, Palm NW. Within-host evolution of a gut pathobiont facilitates liver translocation. Nature 607, 563-570 (2022) Kim CS, Gatsios A, Guesta S, Lam YC, Wei Z, Chen H, Russell RM, Shine EE, Wang R, Wyche TP, Piizzi G, Flavell RA, Palm NW, Sperandio V, Crawford JM. Characterization of autoinducer-3 structure and biosynthesis in E.Coli. ACS Cent. Sci. 2020, 6, 197-206 OhJ,KinNY,ChenH,PalmNW,CrawfordJM.AnUgi-likebiosynthetic pathway encodes bombesinreceptorsubtype-3agonists.J.Am.Chem.Soc. 2019,141,41, 16271-16278 ChenH,NwePK,YangY,RosenCE,BieleckaAA,KuchrooM,ClineGW, Kruse AC, RingAM,CrawfordJM,PalmNW.Aforwardchemicalgeneticscreen reveals gut microbiota metabolitesthatmodulatehostphysiology.Cell.2019May16; 177(5): 1217-1231. e18. ZhuS,DingS, WangP,WeiZ,PanW,PalmNW,YangY,YuH,LiHB, Wang G, Lei X, deZoeteMR,ZhaoJ,ZhengY,ChenH,ZhaoY,JuradoKA,FengN,ShanL, Kluger Y, LuJ,AbrahamC,FikrigE,GreenbergHB,FlavellRA. Nlrp9b inflammasome restricts rotavirusinfectioninintestinalepithelialcells. Nature.2017Jun29; 546(7660):667-670 Li M, DiW,XuH,YangY,ChenH,ZhangF,ZhaiZ,ChenD.Negativeregulation of RIG-I-mediated innate antiviral signaling by SEC14L1. J Virol. 87(18): 10037-46. PMID: 23843640 YangZ,LiangH,ZhouQ,LiY,ChenH,YeW,ChenD,FlemingJ,ShuH,LiuY.CrystalstructureofISG54revealsanovelRNAbindingstructureandpotentialfunctionalmechanisms.CellRes.22:1328-38.PMID:22825553. YangY,QuH,GaoD,DiW,ChenH,GuoX,ZhaiZ,ChenD.ARF-likeprotein16(ARL16)inhibitsRIG-IbybindingwithitsC-terminaldomaininaGTP-dependentmanner.JBiolChem;286(12):10568-80.PMID:21233210. Chen H, Yang Y, Xu H, Yang W, Zhai Z, Chen DY. Ring finger protein 166 potentiates RNA virus-induced interferon- production via enhancing the ubiquitination of TRAF3 and TRAF6. Scientific Reports 5, 14770. PMID: 26456228.