黄立豪 - 复旦大学 - 代谢与整合生物学研究院

个人简介

2018-2020年美国圣路易华盛顿大学医学院，免疫及病理学系，讲师 2014-2018年美国圣路易华盛顿大学医学院，免疫及病理学系，博士后 2007-2013年美国达特茅斯医学院, 生化系，博士荣誉及获奖情况 2019 Kern Lipid Conference Early Career Investigator Award 2019 Lymphatic Education & Research Network (LE&RN) Travel Award 2019 American Association of Immunologists Trainee Abstract Award 2018 Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH 2018 American Heart Association Career Development Award 2018 Travel Award, HDL Workshop in ATVB, San Francisco, CA 2017 Best Poster Award, Sixth Annual Cardiovascular Research Day, St. Louis, MO 2017 FASEB MARC Travel Award 2017 Lymphatic Education & Research Network (LE&RN) Travel Award 2016 Best Poster Award, Fifth Annual Cardiovascular Research Day, St. Louis, MO 2016 Best Travel Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH 2016 Lymphatic Education & Research Network (LE&RN) Travel Award 2014 Institutional Training Grant (T32), Department of Pathology & Immunology Washington University 2014 Best Poster Award, Lipoprotein Metabolism Gordon Conference, Waterville Resort, NH

研究领域

研究自体免疫疾病(包括牛皮癣和肠道炎症)免疫应激如何影响脂代谢穏态及动脉粥样硬化、脂肪肝、胰岛素抵抗、糖尿病等代谢疾病进程。利用多领域多学科包括免疫、代谢、淋巴管、脂蛋白和生化技术解决单一学科不容易解决的问题；并整合细胞，小鼠和人类临床转化的方法来实现新药开发以减缓疾病的进程。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Huang L H, Parakkal D, Ciorba M A, Mittendorfer B, Patterson B W, Randolph G J. TNF-targeting Therapeutics selectively increase postprandial chylomicron output and endocrine hormone secretion in subjects with active crohn’s disease.2020 Gastroenterology, 159 (5):1955-1957. Huang L H, Zinselmeyer B H, Chang C H, Saunders B T, Kim B S, Wiig H, Thomas M J, Sorci-Thomas M G, Randolph G J. Interleukin 17-driven trapping of tissue lipoproteins links immunity to cardiovascular risk in murine psoriasis. Cell Metabolism, 2019, 29, 475-487. Huang L H#, Melton E#, Sohn P, Jung D Y, Tsai C Y, Ma T, Sano H, Ha H, Friedline R, Kim J, Usherwood E,Chang C C, Chang T Y. Myeloid-specific ACAT1 gene ablation in mouse reduces adipose tissue macrophage content, improves insulin sensitivity and suppresses diet-induced obesity. American Journal of Physiology-Endocrinology and Metabolism, 2018, 315(3): E340-E356. Huang L H*, Kavine K J, Randolph G J*. Cardiac lymphatic Vessels, transport, and healing of the infarcted heart. Journal of the American College of Cardiology-Basic Transl Sci., 2017, 2 (4): 477-483. Huang L H#, Melton E#, Sohn P, Li H B, Jung D Y, Rogers M A, Sano H, Ma T, Fiering S N, Ha H K, Friedline R H,Jason K K, Chang C C, Chang T Y. Myeloid-Acyl-CoA:Cholesterol Acyltransferase 1 deficiency reduces lesion macrophage content and suppresses atherosclerosis progression. Journal of Biological Chemistry, 2016, 291(12): 6232-6244. Huang L H, Elvinton A, Randolph G. The role of the lymphatic system in cholesterol transport. Fortier in Pharmacology, 2015, 6:182. Huang L H, Nishi K, Li S, Ho T, Dong R H, Chang C C, Chang T Y. Acyl-Coenzyme A: cholesterol acyltransferase 1: significance of single nucleotide polymorphism at residue 526 and role of proline 347 near the fifth transmembrane domain. FEBS J., 2014, 281(7): 1773-1783. Huang L H, Gui J G, Artinger E, Craig R, Berwin B L, Ernst P A, Chang C C, Chang T Y. Acat1 gene ablation in mice increases hematopoietic progenitor cell proliferation in bone marrow and causes leukocytosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 2013, 33(9): 2081-2087. Chang, T. Y., Chang, C. C., Huang, L. H., Melton, E., Sohn, P.. Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis. Jan. 2, 2018. Application number: 15035780. Chang, T. Y., Chang, C. C., Huang, L. H.. Methods for treating immunosuppression. Jun. 19, 2014. Application number: 14236629.