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Mengjing Wang, Qianqian Li, Meifang Hou, Louisa LY Chan, Meng Liu, Soo Kai Terd, Ting Dong, Yun Xia*, Sanjay H Chotirmalld, Mingliang Fang*. Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early-life allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 2021
Beyer, B. A.#, Fang, M.# （Equal Contribution）, Sadrian, B., Montenegro-Burke, J. R., Plaisted, W. C., Kok, B. P., ... & Lairson, L. L*. (2018). Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature Chemical Biology, 14(1), 22-28. https://doi.org/10.1038/nchembio.2517
M Fang, L Hu, D Chen, Y Guo, J Liu, C Lan, J Gong, B Wang. “Exposome” in Human Health: Utopia or Wonderland? The Innovation, 100172, 2021
Fanrong Zhao, Li Li, Yue Chen, Yichao Huang, Tharushi Prabha Keerthisinghe, Agnes Chow, Ting Dong, Shenglan Jia, Shipei Xing, Benedikt Warth, Tao Huan and Mingliang Fang*. Risk-based Chemical Ranking and Generating a Prioritized Human Exposome Database. Environmental Health Perspective. 2021.
Liu, M., Jia, S., Dong, T., Zhao, F., Xu, T., Yang, Q., ... & Fang, M*. (2020). Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects. Environmental Health Perspectives https://doi.org/10.1289/EHP6641
Fang, M., Webster, T. F., Ferguson, P. L., & Stapleton, H. M*. (2015). Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environmental Health Perspectives, 123(2), 166-172. https://doi.org/10.1289/ehp.1408522
Pillai, H. K., Fang, M., Beglov, D., Kozakov, D., Vajda, S., Stapleton, H. M., ... & Schlezinger, J. J*. (2014). Ligand Binding and Activation of PPAR γ by Firemaster? 550: Effects on Adipogenesis and Osteogenesis in Vitro. Environmental Health Perspectives, 122(11), 1225-1232. https://doi.org/10.1289/ehp.1408111
Hoffman, K.#, Fang, M.# （Equal Contribution）, Horman, B., Patisaul, H. B., Garantziotis, S., Birnbaum, L. S., & Stapleton, H. M. *(2014). Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster? 550. Environmental Health Perspectives, 122(9), 963-969. https://doi.org/10.1289/ehp.1308028
Liu, Min; Jiang, Jie; Jie, Zheng; Huan, Tao; Gao, Bei ; Fei, Xunchang; Wang, Yulan; Fang, Mingliang*. RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology. 2021.
Xu, Tengfei; Chen, Liyan; Lim, Yan Ting; Zhao, Haoduo; Chen, Hongjin; Chen, Mingwei; Huan, Tao; Huang, Yichao; Sobota, Radoslaw ; Fang, Mingliang*. (2021). Systems Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle. Environmental Science & Technology. 2021, 55, 3, 1842–1851.
Xu, T., Lim, Y. T., Chen, L., Zhao, H., Low, J. H., Xia, Y., ... & Fang, M*. (2020). A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c01073
Zhang, Y., Liu, M., Peng, B., Jia, S., Koh, D., Wang, Y., ... & Fang, M*. (2020). Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems Biological Understanding of Synergism between Tris (1, 3-dichloro-2-propyl) phosphate and Triphenyl Phosphate. Environmental Science & Technology, 54(17), 10722-10734. https://doi.org/10.1021/acs.est.0c02188
Huang, Y., & Fang, M*. (2020). Nutritional and Environmental Contaminant Exposure: A Tale of Two Co-Existing Factors for Disease Risks. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c05658
M Liu, B Peng, G Su, M Fang*. Reactive Flame Retardants: Are They Safer Replacements? Environmental Science & Technology. 2021.
Setyawati, M. I., Singh, D., Krishnan, S. P., Huang, X., Wang, M., Jia, S., Fang, M., ... & Poh, T. Y. (2020). Occupational Inhalation Exposures to Nanoparticles at Six Singapore Printing Centers. Environmental Science & Technology, 54(4), 2389-2400. https://doi.org/10.1021/acs.est.9b06984
Peng, B., Liu, M., Han, Y., Wanjaya, E. R., & Fang, M*. (2019). Competitive biotransformation among phenolic xenobiotic mixtures: Underestimated risks for toxicity assessment. Environmental Science & Technology, 53(20), 12081-12090. https://doi.org/10.1021/acs.est.9b04968
Dong, T.#, Zhang, Y.#, Jia, S., Shang, H., Fang, W., Chen, D., & Fang, M*. (2019). Human indoor exposome of chemicals in dust and risk prioritization using EPA’s ToxCast database. Environmental Science & Technology, 53(12), 7045-7054. https://doi.org/10.1021/acs.est.9b00280
Jia, S., Xu, T., Huan, T., Chong, M., Liu, M., Fang, W., & Fang, M*. (2019). Chemical isotope labeling exposome (CIL-EXPOSOME): one high-throughput platform for human urinary global exposome characterization. Environmental Science & Technology, 53(9), 5445-5453. https://doi.org/10.1021/acs.est.9b00285
Zhang, Y., Keerthisinghe, T. P., Han, Y., Liu, M., Wanjaya, E. R., & Fang, M*. (2018). “Cocktail” of xenobiotics at human relevant levels reshapes the gut bacterial metabolome in a species-specific manner. Environmental Science & Technology, 52(19), 11402-11410. https://doi.org/10.1021/acs.est.8b02629
Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Effect-Directed Analysis of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) Ligands in Indoor Dust. Environmental Science & Technology, 49(16), 10065-10073. https://doi.org/10.1021/acs.est.5b01524
Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Environmental Science & Technology, 49(16), 10057-10064. https://doi.org/10.1021/acs.est.5b01523
Fang, M., & Stapleton, H. M.* (2014). Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method. Environmental Science & Technology, 48(22), 13323-13330. https://doi.org/10.1021/es503918m
Fang, M., Webster, T. F., Gooden, D., Cooper, E. M., McClean, M. D., Carignan, C., ... & Stapleton, H. M*. (2013). Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust. Environmental Science & Technology, 47(9), 4449-4454. https://doi.org/10.1021/es400032v
Chen, Xing; Zhang, Keda; Yin, Zhihong; Fang, Mingliang; Pu, Weidan; Liu, Zhening; Li, Lei; Sinues, Pablo; Dallmann, Robert; Zhou, Zhen; Li, Xue. Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Non-Volatile Drugs from Blood to Breath. Analytical Chemistry, 2021.
T Xu, H Zhao, M Wang, A Chow, M Fang*. Metabolomics and in-silico docking-directed discovery of small-molecule enzyme targets. Analytical Chemistry. 2021.
Xing, S., Hu, Y., Yin, Z., Liu, M., Tang, X., Fang, M., & Huan, T.* (2020). Retrieving and Utilizing Hypothetical Neutral Losses from Tandem Mass Spectra for Spectral Similarity Analysis and Unknown Metabolite Annotation. Analytical Chemistry (Washington), 92(21), 14476-14483. https://doi.org/10.1021/acs.analchem.0c02521
Fang, M., Ivanisevic, J., Benton, H. P., Johnson, C. H., Patti, G. J., Hoang, L. T., ... & Siuzdak, G*. (2015). Thermal degradation of small molecules: a global metabolomic investigation. Analytical Chemistry (Washington), 87(21), 10935-10941. https://doi.org/10.1021/acs.analchem.5b03003
Warth, B., Spangler, S., Fang, M., Johnson, C. H., Forsberg, E. M., Granados, A., ... & Montenegro-Burke, J. R. (2017). Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing. Analytical Chemistry 89(21), 11505–11513. https://doi.org/10.1021/acs.analchem.7b02759
Preindl, K., Braun, D., Aichinger, G., Sieri, S., Fang, M., Marko, D., & Warth, B*. (2019). A Generic Liquid Chromatography?Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices. Analytical Chemistry (Washington), 91(17), 11334–11342. https://doi.org/10.1021/acs.analchem.9b02446
H Zhao, Liu, Min, Y Lv, M Fang*. Dose-response Metabolomics and Pathway Sensitivity to Map Molecular Cartography of Bisphenol A Exposure. Environment International. 2021.
D Wang, H Zhao, XunchangFei, SA Synder, M Fang*, M Liu*. A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE. Environment International. 2021.
Keerthisinghe, T. P., Wang, M., Zhang, Y., Dong, W., & Fang, M*. (2019). Low-dose tetracycline exposure alters gut bacterial metabolism and host-immune response:“Personalized” effect?. Environment International, 131, 104989. https://doi.org/10.1016/j.envint.2019.104989
Keerthisinghe, T. P.#, Wang, F.#, Wang, M., Yang, Q., Li, J., Yang, J., ... & Fang, M*. (2020). Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome. Environment International, 139, 105705. https://doi.org/10.1016/j.envint.2020.105705
Fang, M., Getzinger, G. J., Cooper, E. M., Clark, B. W., Garner, L. V., Di Giulio, R. T., ... & Stapleton, H. M.* (2014). Effect‐directed analysis of Elizabeth River porewater: Developmental toxicity in zebrafish (Danio rerio). Environmental Toxicology and Chemistry, 33(12), 2767-2774. https://doi.org/10.1002/etc.2738
Fang, M.*, Guo, J., Chen, D., Li, A., Hinton, D. E., & Dong, W*. (2016). Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos. Environmental Toxicology and Chemistry, 35(10), 2523-2529. https://doi.org/10.1002/etc.3416.
Yang, J. J., Han, Y., Mah, C. H., Wanjaya, E., Peng, B., Xu, T. F., ... & Fang, M. L*. (2020). Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction. Analytica Chimica Acta, 1100, 88-96. https://doi.org/10.1016/j.aca.2019.12.002
Shenglan Jia, Magdiel Inggrid Setyawati, Min Liu, Tengfei Xu, Joachim Loo, Meilin Yan, Jicheng Gong, Sanjay H Chotirmall, Philip Demokritou, Kee Woei Ng, Mingliang Fang*. Association of Nanoparticle Exposure with Serum Metabolic Disorders of Healthy Adults in Printing Centres. Journal of Hazardous Materials, 128710, 2022
B Peng, H Zhao, TP Keerthisinghe, Y Yu, D Chen, Y Huang*, M Fang*. Gut microbial metabolite p-cresol alters biotransformation of bisphenol A: Enzyme competition or gene induction? Journal of Hazardous Materials 426, 2022.
Mengjing Wang, Shenglan Jia, Agnes Chow, Mingliang Fang*. Polycyclic aromatic hydrocarbons (PAHs) in indoor environment are still imposing carcinogenic risk Journal of Hazardous Materials. Journal of Hazardous Material. 2020.
TP Keerthisinghe, Q Yang, A Chow, M Fang*. Feeding State Greatly Modulates the Effect of Xenobiotics on Gut Microbiome Metabolism: A Case Study of Tetracycline. Journal of Hazardous Materials. 2021. doi.org/10.1016/j.jhazmat.2021.125441.
Li, J.#, Dong, T.#, Keerthisinghe, T. P., Chen, H., Li, M., Chu, W., ... & Fang, M*. (2020). Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of Hazardous Materials, 123061. https://doi.org/10.1016/j.jhazmat.2020.123061
Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., ... & Thorgersen, M. P. (2017). Systems biology guided by XCMS Online metabolomics. Nature Methods, 14(5), 461-462. https://doi.org/10.1038/nmeth.4260
Guang-Lei Ma, Hartono Candra, Li Mei Pang, Juan Xiong, Yichen Ding, Hoa Thi Tran, Zhen Jie Low, Hong Ye, Min Liu, Jie Zheng, Mingliang Fang, Bin Cao, Zhao-Xun Liang*. Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation. Journal of the American Chemical Society. 2022.
GL Ma, HT Tran, ZJ Low, H Candra, LM Pang, QW Cheang, M Fang and ZX Liang*. Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes. Journal of the American Chemical Society. 2021.
Xunchang Fei, Mingliang Fang. Climate change affects land-disposed waste. Nature Climate Change, 2021.
Low, J. H., Li, P., Chew, E. G. Y., Zhou, B., Suzuki, K., Zhang, T., Fang, M. et.al (2019). Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell, 25(3), 373-387. https://doi.org/10.1016/j.stem.2019.06.009
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