程喆 - 厦门大学 - 生命科学学院

个人简介

2003年，西北大学生命科学专业，学士学位 2009年，厦门大学动物学专业，博士学位 2020年，厦门大学生命科学学院，副教授 B.S. 2003, Northwest University, Life Science Ph.D. 2009, Xiamen University, Zoology Associate Professor, School of Life Sciences, Xiamen University, 2020 to Present.

研究领域

以人体重要寄生病原泡球蚴为研究模型，探究宿主-寄生虫间的互作关系，分析宿主因子介导的相关信号通路在寄生虫生长发育过程中的作用；泡球蚴成体干细胞自我更新、多能性维持和细胞特化的机制以及宿主因子对其影响。

近期论文

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Cheng Z, Xu Z, Tian H, Liu F, Li X, Luo D, Wang Y. In vitro and in vivo efficacies of the EGFR/MEK/ERK signaling inhibitors in the treatment of alveolar echinococcosis. Antimicrob Agents Chemother. 2020, 64(8): e00341-20. Cheng Z, Liu F, Tian H, Xu Z, Chai X, Luo D, Wang Y. Impairing the maintenance of germinative cells in Echinococcus multilocularis by targeting Aurora kinase. PLoS Negl Trop Dis. 2019, 13(5): e0007425. Cheng Z, Liu F, Dai M, Wu J, Li X, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells. Int J Parasitol. , 2017, 47(10-11): 625-632. Cheng Z, Liu F, Li X, Dai M, Wu J, Guo X, Tian H, Heng Z, Lu Y, Chai X, Wang Y, EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development. PLoS Negl Trop Dis. , 2017, 11(2): e0005418. Cheng Z, Zhu S, Wang L, Liu F, Tian H, Pengsakul T, Wang Y, Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response. Int J Parasitol. , 2015, 45(8): 517-526. Cheng Z, Liu F, Zhu S, Wang L, Wang Y, A rapid and convenient method for fluorescence analysis of in vitro cultivated metacestode vesicles from Echinococcus multilocularis. PLoS One, 2015, 10(2): e0118215. Cheng Z, Tian H, Chu H, Wu J, Li Y, Wang Y, The effect of tributyltin chloride on Caenorhabditis elegans germline is mediated by a conserved DNA damage checkpoint pathway. Toxicol Lett. , 2014, 225(3): 413-421. Wang Y#, Cheng Z#, Lu X, Tang C, Echinococcus multilocularis: Proteomic analysis of the protoscoleces by two-dimensional electrophoresis and mass spectrometry. Exp Parasitol. , 2009, 123(2): 162-167.