研究领域
Bacteria-Surface Interactions on the Molecular Scale
Bacteria often attach to surfaces and form communities called biofilms. Biofilms are so ubiquitous that they constitute one of the major forms of biomass on Earth. The ability to control the interaction between bacteria and surfaces would have a range of applications, including in health (e.g., microbiome engineering), industry (e.g., alleviating freshwater scarcity), and environmental preservation (e.g., protecting vulnerable ecosystems from pathogenic invasion). We use polymer vapor deposition techniques to create surfaces that allow the manipulation of bacteria-surface interactions via nanometer-scale heterogeneities.
Redesign Porous Membranes in Healthcare and Sustainability
Membrane separation is indispensable for today’s health care and sustainability, with applications ranging from hemodialysis/hemofiltration to water purification and energy storage. Low throughput, poor selectivity, and fouling are pervasive issues with virtually all membrane separation processes.
We capitalize on the conformal nature of the vapor-deposited polymers to achieve uniform coverage inside porous membranes, thereby controlling liquid-solid interface interactions and overcoming the aforementioned limitations.
Material-Based Solutions to Antibiotic Resistance
Antibiotic resistance is a leading and growing cause of death worldwide, undermining not only our ability to fight infectious diseases, but also the success of surgery, dialysis, and cancer chemotherapy. We develop material-based antibiotic treatments that disinfect by converting secreted metabolic products of pathogens to antimicrobials in situ.
近期论文
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Ma X., Lang J., Chen P., Tang W., Yang R.*, “A cascade nanozyme with antimicrobial effects against nontypeable Haemophilus influenzae”, Nanoscale 2023, in print. Invited submission.
Chen P., Zhang Z., Rouse Z., Baker S.P., Yeo J.*, Yang R.*, “Engineering solvation in initiated chemical vapour deposition (iCVD) for process-property control”, Nature Synthesis 2023, in print.
Shindler S., Yang R.*, “Hydrolysis of poly(fluoroacrylate) thin films synthesized from the vapor phase”, Langmuir 2023, in print.
Lang J.,† Ma X.,† Liu S., Streever D., Serota M., Franklin T., Loew E.R., Yang R.*, “On-Demand Synthesis of Antiseptics at the Site of Infection for Treatment of Otitis Media”, Nano Today 2022, 47: 101672.
Shuo J,† Chen, P.,† Qiu, Y., Zhang, Z., Hong, S., Joo, Y.L.,* Yang, R.* Archer, L.*, “Zwitterionic polymer gradient interphases for reversible Zinc electrochemistry in aqueous alkaline electrolytes”, Journal of the American Chemical Society 2022, 144(42): 19344-19352.
Khlyustova A., Kirsch M., Yang R.*, “Amphiphilic copolymer thin films with short perfluoroalkyl side chains enable enhanced antifouling and fouling release properties”, ACS Sustainable Chemistry and Engineering 2022, 10 (48): 15699-15713.
Liu S., Yang R.*, “Inner ear drug delivery for sensorineural hearing loss: current challenges and opportunities”, Frontiers in Neuroscience 2022, 747. Invited submission.
Franklin T., Streever D., Yang R., “Versatile and rapid synthesis of polymer nanodomes via template- and solvent-free condensed polymerization”, Chemistry of Materials 2022, in print.
Khlyustova A., Kirsch M., Ma X., Cheng Y., Yang R., “Surfaces with Antifouling-Antimicrobial Dual Function via Immobilization of Lysozyme on Zwitterionic Polymer Thin Films”, Journal of Materials Chemistry B 2022, doi:10.1039/d1tb02597j
Cheng Y., Khlyustova A., Chen P., Yang R., “All-dry free radical polymerization inside nanopores: ion-milling-enabled coating thickness profiling revealed ‘necking’ phenomena”, Journal of Vacuum Science & Technology A 2022, 40(3): 033406. Invited submission.
Lang L., Ma X., Chen P., Serota M., Andre N.M., Whittaker G.R., Yang R., “Haloperoxidase-mimickingCeO2-xnanorods for the deactivation of human coronavirus OC43”, Nanoscale 2022, 14: 3731-3737.
Chen P., Lang J., Zhou Y., Khlyustova A., Zhang Z., Ma. X., Liu S., Cheng Y., Yang R. “An Imidazolium-Based Zwitterionic Polymer for Antiviral and Antibacterial Dual-Functional Coatings”, Science Advances 2022, 8 (2), eabl8812.
Franklin T., Wu Y., Lang J., Li S., Yang. R., “Design of Polymeric Thin Films to Direct Microbial Biofilm Growth, Virulence, and Metabolism”, Biomacromolecules 2021, doi:10.1021/acs.biomac.1c00731
Stalin S., Chen P., Li G., Deng Y., Rouse Z., Cheng Y., Zhang Z., Biswal P., Jin S., Baker S. P., Yang R., Archer L.A., “Ultrathin zwitterionic polymeric interphases for stable lithium metal anodes”, Matter 2021, 4 (11), 3753-3773.
Cheng Y., Yang R., “Toward Programming Bacterial Behavior via Synthetic Interfaces: Physicochemical Nanopatterning, Decoupling Surfaces Properties, and Integrating Material and Biological Insights”, Accounts of Materials Research 2021, 2 (11), 979-985.
Ma X., Lang J., Chen P., Yang R., “Silver Nanoparticles as an Effective Antimicrobial against Otitis Media Pathogens”, AIChE Journal 2021, 67 (12), e17468.
Khlyustova A., Yang R., “Initiated Chemical Vapor Deposition Kinetics of Poly(4-aminostyrene)”, Frontiers in Bioengineering and Biotechnology 2021, 9,309.
Chen P., Lang J., Franklin T., Yu Z., Yang R., “Reduced Biofilm Formation at the Air-Liquid-Solid Interface via Introduction of Surfactants”, ACS Biomaterials Science & Engineering 2021, doi:10.1021/acsbiomaterials.0c01691
Donadt T., Yang R., “Amphiphilic Polymer Thin Films with Enhanced Resistance to Biofilm Formation at the Solid–Liquid–Air Interface”, Advanced Materials Interfaces 2021, 8 (5), 2001791.
Cheng, Y., Khlyustova, A., Chen, P., Yang, R., “Kinetics of All-Dry Free Radical Polymerization under Nanoconfinement”, Macromolecules 2020, 53 (24), 10699.
Khlyustova A., Cheng Y., Yang R., “Vapor-deposited functional polymer thin films in biological applications”, Journal of Materials Chemistry B 2020, 8 (31), 6588.
Franklin T., Yang R., “Vapor-deposited biointerfaces and bacteria: an evolving conversation”, ACS Biomaterials Science & Engineering 2020, 6, 1.
Zhao C., Liu A., Santamaria C., Shomorony A., Ji T., Wei T., Gordon A., Elofsson H., Mehta M., Yang R., Kohane D., “Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity”, Nature Communications 2019, 10, 2566.
Yang R., Saarinen R., Okonkwo O.S., Hao Y., Mehta M., Kohane D.S., “Transtympanic delivery of local anesthetics for pain in acute otitis media”, Molecular Pharmaceutics 2019, 16,4.
Yang R., Sabharwal V., Shlykova N., Okonkwo O. S., Pelton S. I., Kohane D. S., “Treatment of Streptococcus pneumoniae otitis media in a chinchilla model by trans-tympanic delivery of antibiotics”, JCI Insight 2018, 3, 19.
Yang R., Okonkwo O. S., Zurakowski D., Kohane D. S., “Synergy between chemical permeation enhancers and drug permeation across the tympanic membrane”, Journal of Controlled Release 2018, 289, 10.
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