个人简介
科研立项
作为负责人主持科研项目12项，其中国家自然科学基金3项
国家自然基金委员会，面上项目，82171183，“应激颗粒介导麻醉和手术促进阿尔茨海默病快速进展的机制研究”，2022-01至2025-12，55万元，在研
国家自然基金委员会，面上项目，81771269，“β-arrestin2在δ阿片受体激动剂抑制TLR4炎症通路减轻脑缺血再灌注损伤中的作用及机制研究”，2018.01至2021.12，54万元，结题
国家自然基金委员会，青年项目，30901392，“腹主动脉内局部灌注克伦特罗和丁氧胺调控β2 肾上腺素受体对脊髓缺血再灌注损伤保护作用及机制的研究”，2010.01至2012.12，20万元，结题
上海市人力资源和社会保障局，上海市浦江人才计划资助课题，17PJD035，“Wnt /β-catenin/GSK3β信号通路受抑介导的Tau蛋白病变及炎症反应在AD患者麻醉手术后认知功能恶化中的作用”，2017.09至2019.09，20万元，结题
上海市科学技术委员会，上海市自然基金面上项目，15ZR1433800，“β2肾上腺素受体与δ阿片受体寡聚化减轻脊髓缺血再灌注损伤的作用及机制研究”，2015.01至2017.12，10万元，结题
上海申康医院发展中心，临床科技创新项目，SHDC12019102，“术前脑小血管病影像学评估与围术期隐匿性脑卒中的相关性研究”，2019.12至2022.11 ，32万元，在研，分中心负责人
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Zhang Junyao; Zhang Tong; Wang Yinuo; Yao Liangfang; Yao Junyan*. Gα13-mediated Signaling Cascade was related to the Anesthesia and Surgery caused tau Pathology in 5XFAD Transgenic Mice, J Alzheimers Disease,Journal of Alzheimer's disease : JAD, 2023.93(2),545-560
Yinuo Wang, Junyao Zhang, Yingying Zhang , Junyan Yao*. Bibliometric analysis of global research profile on ketogenic diet therapies in neurological diseases: Beneficial diet therapies deserve more attention. Frontiers in Endocrinology. DOI:10.3389/fendo.2022.1066785
Ying Zhao, Peng Pan, Yue Lei, Danyun Fu, Junyan Yao*. Ultrasound-guided transversus thoracic muscle plane-pectoral nerve block for postoperative analgesia after modified radical mastectomy: a comparison with thoracic paravertebral nerve block. Perioperative medicine. 2022(11):39.
Yang Shen, Tong Zhang, Yinglin Zhang, Yinuo Wang, Junyan Yao* Stress granules modulate SYK to cause tau-associated neurocognitive deterioration in 5XFAD mice after anesthesia and surgery. Frontiers in aging neuroscience. 2021,27;13:718701.
Shen Yang, Li X, Yao Junyan *. Develop a clinical prediction model for postoperative cognitive dysfunction after major non-cardiac surgery in elderly patients: a protocol for a prospective observational study. Gerontology. 2021 Jul,27:1-8.
Tong Zhang, Yang Shen, Yiqing Guo, Junyan Yao*. Identification of key transcriptome biomarkers based on a vital gene module associated with pathological changes in Alzheimer’s disease. Ageing,2021,13:14940-14967.
Fu Danyun, Liu Haitong, Zhujiang, Xu Hongjiao, Junyan Yao*. D-Ala2, D-Leu5] Enkephalin Inhibits TLR4/NF-κB Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury, Mediators of In?ammation, 2021,2021：6661620
Hua Liu, Xiaojian Weng, Junyan Yao, Jun Zheng, Xiang Lv, Xuhui Zhou, Hong Jiang*, Shitong Li*. Neuregulin-1β Protects the Rat Diaphragm during Sepsis against Oxidative Stress and Inflammation by Activating the PI3K/Akt Pathway. Oxidative Medicine and Cellular Longevity. 2020, 2020:1720961.
Linwen Liu, Yongfu Xu, Yachun Zhou, Shitong Li, Junyan Yao*. Regionally infused Lidocaine can dose-dependently protect the ischemic spinal cord in rabbits and may be associated with the EAA Changes. Neuroscience Letters. 2020 Apr 23,725:134889.
Danyun Fu, Haitong Liu, Hua liu, Junyan Yao*. Effects of [D-Ala2, D-Leu5] enkephalin preconditioning and postconditioning in a rabbit model of spinal cord ischemia and reperfusion injury. Molecular Medicine Report. 2019 Dec;20(6):4811-4820.
Danyun Fu, Haitong Liu, Shitong Li, Lianhua Chen, Junyan Yao*. Antioxidative and antiapoptotic effects of Delta-Opioid Peptide [D-Ala2, D-Leu5] Enkephalin on spinal cord ischemia-reperfusion injury in rabbits. Frontiers in neuroscience. 2017 October; 11:603
Hua Liu, Jin Wu, Junyan Yao, Hong Wang, Shi tong Li. The role of oxidative stress in decreased acetylcholinesterase activity at the neuromuscular junction of the diaphragm during sepsis. Oxidative Medicine and Cellular Longevity. 2017,2017: 9718615
Danyun Fu, Haitong Liu, Hui Zhu, Shitong Li, Junyan Yao*. Protective effect of delta opioid receptor agonist (D-Ala2, D-Leu5) enkephalin on permanent focal cerebral ischemia in rats. Neuroreport, 2016, July 6;27(10) 749-754.
Haitong Liu, Binbin Chen, ShitongLi, JunyanYao*. Dose-dependent neuroprotection of delta-opioid peptide [D-Ala 2, D-Leu5] enkephalin on spinal cord ischemia-reperfusion injury by regional perfusion into the abdominal aorta in rabbits. Journal of Vascular Surgery, 2016 April;63(4):1074-1081
张童，姚俊岩*.内嗅皮层在阿尔茨海默病患者记忆损害发生和发展中的作用. 国际麻醉学与复苏, 2021,42(6):664-667
赵赢，邵安民，冯树全，张代玲，雷月，姚俊岩*。超声引导下胸壁神经阻滞与胸椎旁神经阻滞用于乳腺癌改良根治术患者围术期的镇痛效果与安全性比较。临床麻醉学杂志，2020, 36(1):762-767
张童，张莹林，姚俊岩*。不同测试指标及观测时段对情景条件恐惧实验检测5XFAD转基因小鼠行为学效力的影响。上海交通大学学报（医学版），2020, 40(6): 58-62
刘麟文，周雅春，姚俊岩*。DADLE对SH-SY5Y细胞缺氧复氧损伤的保护作用[J].解剖学杂志,2020,43(1):31-36.
张莹林，郭依清，张童， 蒋明，沈阳，姚俊岩*。Morris水迷宫逃避潜伏期阈值设定对检测结果的影响. 现代生物医学进展,2020,20(8):1435-1439
沈阳，姚俊岩*.趋化因子CX3CL1及其受体CX3CR1 在阿尔茨海默病中的作用研究进展. 国际麻醉学与复苏杂志, 2020, 41(9): 920-924
张莹林，姚俊岩*。长链非编码RNAs与缺血性脑卒中关系的研究进展. 国际麻醉学与复苏, 2019,40(7):699-703
刘麟文，姚俊岩*。Tau蛋白导致认知功能障碍的研究进展.国际麻醉学与复苏, 2019,4,40(4):403-407
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