个人简介
科研课题
张江高科技园区重点项目子课题(在研,第一负责人);项目名称:建立NGS技术检测外周血cfDNA的检测平台(2016-08);研究经费:800万;研究时间:2016年8月至2020年12月
中央高校基本科研业务费专项资金资助(已结题,第一负责人);项目名称:c-KIT/PDGFα-EMT-肿瘤亚克隆演化在非小细胞肺癌EGFR-TKIs获得性耐药中作用及分子机制探讨(22120180369);研究经费:5万;研究时间:2018年9月至2019年8月
国基金青年项目(已结题,第一负责人);项目名称:国基金青年项目(已结题,第一负责人);项目名称:分化抑制因子ID1在非小细胞肺癌EGFR-TKIs耐药中的作用和机制研究”(项目批准号:81301994)研究经费:23万;研究时间:2014年1月至2016年12月
研究领域
非小细胞肺癌液态活检、非小细胞肺癌个体化精准治疗及靶向药耐药研究、肺癌纳米靶向化疗药研究
近期论文
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Exosomal long non-coding RNA MSTRG.292666.16 is associated with osimertinib (AZD9291) resistance in non-small cell lung cancer. Aging (Albany NY). 2020, 12(9):8001-8015;
Cyclooxygenase-2 mediates gefitinib resistance in non-small cell lung cancer through the EGFR/PI3K/AKT axis. Journal of Cancer, 2020;
Detection of plasma EGFR mutations for personalized treatment of lung cancer patients without pathologic diagnosis. Cancer Medcine, 2020;
Predictive value of unmethylated RASSF1A on disease progression in non-small cell lung cancer patients receiving pemetrexed-based chemotherapy. Cancer Biomarkers, 2020;
A novel virtual barcode strategy for accurate panel-wide variant calling in circulating tumor DNA. BMC Bioinformatics, 2020;
Competitive evolution of NSCLC tumor clones and the drug resistance mechanism of first-generation EGFR-TKIs in Chinese NSCLC patients. Heliyon, 2018;
Engineering docetaxel-loaded micelles for nonsmall cell lung cancer: a comparative study of microfluidic and bulk nanoparticle preparation. RSC Advances, 2018;
SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth. Biochem Biophys Res Commun,2017;
Cancer-related triplets of mRNA-lncRNA-miRNA revealed by integrative network in uterine corpus endometrial carcinoma. BioMed Research International, 2017.