田赟 - 同济大学

个人简介

主持国家自然基金青年项目一项(No. 81302110)、上海市自然科学基金面上项目一项(No. 19ZR1447100)、参与多项国家自然基金和省部级课题。以第一或并列第一作者发表SCI论文10余篇，累计影响因子>30分，单篇最高被引18次。

研究领域

基础研究：肠道微生态影响PD-1单抗在包括恶性黑色素瘤在内的实体瘤的免疫治疗。我们的研究团队聚焦炎性肠病和结直肠癌粘膜免疫紊乱的研究。我们团队早先的研究发现阿司匹林通过干预IL-6/STAT3/SOCS3信号通路在肠炎相关肠癌中发挥作用。近年来团队聚焦炎症和癌症的关系研究，尤其慢性肠炎相关肠癌的研究。评估谷氨酰胺、膳食纤维和改善肠道菌群在肠炎相关肠癌中的作用，并通过抗炎作用最终达到延缓和治疗炎性癌变。临床研究：为实体瘤患者提供最好的治疗策略，并根据AJCC分期和NCCN指南筛选病人，为病情需要的患者提供适合的临床试验。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Yun Tian, Hamzah Abu-Sbeih, and Yinghong Wang. Immune Checkpoint Inhibitors-Induced Hepatitis , Advances in Experimental Medicine. 2018;995:159-164. (IF 2.126) Yun Tian, Hamzah Abu-Sbeih, and Yinghong Wang. Immune Checkpoint Inhibitors-Induced Colitis. Advances in Experimental Medicine. 2018;995:151-157. (IF 2.126) Yun Tian, Qing Xu, Liqun Sun, Ying Ye, Guozhong Ji. Short-chain fatty acids administration is protective in colitis-associated colorectal cancer development. J Nutr Biochem. 2018 Jul;57:103-109. (IF 4.5) Jie Ding, Juan Li, HaiYan Wang, Yun Tian, Min Xie, XueZhi He, Hao Ji, Zhonghua Ma, Bingqing Hui, Keming Wang, and Guozhong Ji. Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. Cell Death and Disease (2017) 8, e2997. (IF 5.638 并列第一作者) Yun Tian, Keming Wang, Yingrui Fan, et al. Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway. Nutrients. 2016 May 2;8(5). pii: E261. (IF 3.27) Yi Li, Yun Tian, Weiming Zhu, et al. IL-10/microRNA-155/SHIP-1 signaling pathway is crucial for commensal bacteria induced spontaneous colitis, Biochemical Pharmacology, 2016.9.15,116:100-106 (IF 5.091 并列第一作者) Yun Tian, Keming Wang, Juan Li, et al. The association between serum lipids and colorectal neoplasm: a systemic review and meta-analysis. Public Health Nutr. 2015 Mar 17:1-16. (IF 2.483) Yun Tian, Jirong Wang, Ying Ye, et al. Apolipoprotein E Polymorphism and Colorectal Neoplasm: Results from a Meta-Analysis. Plos One. 2014 Jul 16;9(7):e102477. (IF 3.534) Yi Li, Yun Tian, Weiming Zhu, et al. Cesarean delivery and risk of inflammatory bowel disease: a systematic review and meta-analysis. Scandinavian Journal of Gastroenterology. 2014,49(7):834-44. (IF 2.329 并列第一作者) Yun Tian, Keming Wang, Zhaoxia Wang, et al. Chemopreventive effect of dietary glutamine on colitis-associated colon tumorigenesis in mice. Carcinogenesis, 2013, 34(7): 1593-1600. (IF 5.266) Yi Li, Yun Tian, Weiming Zhu, et al. Triptolide induces suppressor of cytokine signaling-3 expression and promotes lamina propria mononuclear cells apoptosis in Crohn's colitis. International Immunopharmacology, 2013,16: 268-274.（IF 2.711 并列第一作者） Yun Tian, Ying Ye, Wei Gao, et al. Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving down-regulation of IL-6-STAT3 signaling pathway. International Journal of Colorectal Disease, 2011, 26:13-22. (IF 2.415) Yun Tian, Yi Li, Zhenhua Hu, et al. Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis. International Journal of Colorectal Disease, 2010,25:161-168. (IF 2.415) 会议论文 Yun Tian, et al. Extracellular Vesicles Derived from HT-29 Colorectal Cancer Cells Induce Endothelial Cell Activation and Procoagulant Activity. Blood(IF11.841). 2015 Dec 3; 126 (23) 3456-3456. Yun Tian, et al. Short-chain fatty acidsadministration is protective in colitis-associated colorectal cancerdevelopment(P112), the 12th Congress of ECCO – Inflammatory Bowel Diseases, Journal of Crohn’s and Colitis(IF6.585). 2017 Feb. Yun Tian, et al. Faecalibacterium prausnitzii prevents tumorigenesis in a model of colitis-associated colorectal cancer (DDW 2017 Abstract # 2643958), Gastroenterology(IF 18.187). 2017 May.