刘瑞芳 - 同济大学

个人简介

科研项目国家自然科学基金面上项目，批准号：81772715，MEG3基因敲除对小鼠前列腺正常功能的影响和与前列腺癌转移的机制研究，2018/01－2021/12，53万元，负责人：刘瑞芳（已批准）国家自然科学基金青年基金项目，批准号81302209，miR-199a-3p靶向CD44+干/祖细胞对前列腺癌发生和转移的抑制作用研究，2014/01－2016/12，23万元，负责人：刘瑞芳（已结题）上海市自然科学基金青年项目，批准号：13ZR1459900，miR-199a-3p对CD44+前列腺癌干/祖细胞的调控作用及其对前列腺癌治疗效果的初步研究，2013/10－2016/09，10万元，负责人：刘瑞芳（已结题）同济大学青年优秀人才培养行动计划，2012KJ041，Hsa-miR-199a-3p对前列腺癌干/祖细胞CD44阳性细胞的作用，2013/01－2014/12，2.5万元，负责人：刘瑞芳（已结题）

研究领域

前列腺癌耐药原因和肿瘤转移的分子机制

近期论文

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B. Xu*, R.F. Liu*, D.X. Zhang, B.G. Liu, K. Racaj, H.P. Chao, X.N. Zhang, T.C. Davis, J.S. Kirk, M. Chen, D.G. Tang. LncRNA MEG3 functions as a tumor-suppressor in prostate cancer. (Eur. Urol, to be submitted) (*Co-first authors) C. Liu*, R.F. Liu*, Q. Deng, B.G. Liu, H.P. Chao, K. Rycaj, Y. Takata, K. Lin, Y. Lu, Y. Zhong, J. Krolewski, J.J. Shen, D.G. Tang. MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes including CD44, Pho GTPases, and EZH2. Nat. Commun. 2017 Jan 23;8:14270. (*Co-first authors) R.F. Liu, C. Liu, D.X. Zhang, B.G. Liu, X. Chen, K. Rycaj, C. Jeter, T.C. Davis, Y.D. Li, J.C. Wang, D.G. Tang. MicroRNA miR-199a-3p exhibits tumor-suppressive functions in prostate cancer via targeting CD44, c-Myc, cyclin D1 and EGFR. Oncotarget. 2016;7:56628-42. X. Chen, Q.H. Li, X. Liu, C. Liu, R.F. Liu, K. Rycaj, D.X. Zhang, B.G. Liu, C. Jeter, T.C. Davis, K. Lin, Y. Lu, H.P. Chao, J.J. Shen, D.G. Tang. Defining a population of stem-like human prostate cancer cells that can generate and propagate castration-resistant prostate cancer. Clin Cancer Res. 2016;22:4505-16. M. Jin, T. Zhang, C. Liu, M. A. Badeaux, B. Liu, R. Liu, C. Jeter, X. Chen, A. V. Vlassov, and D. G. Tang, Microrna-128 suppresses prostate cancer by inhibiting Bmi-1 to inhibit tumor-initiating cells. Cancer Res. 2014;74:4183-95. R.F. Liu, X. Xu, J. Huang, Q.L. Fei, F. Chen, Y.D. Li, Z.G. Han, Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. Cancer Lett. 2013;329:164-73. Y. Li, B. Zhou, J. Dai, R. Liu, Z.G. Han, Aberrant upregulation of LRRC1 contributes to human hepatocellular carcinoma. Mol Biol Rep. 2013;40:4543-51. J. Huang, Q. Deng, Q. Wang, K.Y. Li, J.H. Dai, N. Li, Z.D. Zhu, B. Zhou, X.Y. Liu, R.F. Liu, Q.L. Fei, H. Chen, B. Cai, B. Zhou, H.S. Xiao, L.X. Qin, Z.G. Han, Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Nat Genet. 2012;44:1117-21. X. Xu, R.F. Liu, X. Zhang, L.Y. Huang, F. Chen, Q.L. Fei, Z.G. Han, DLK1 as a potential target against cancer stem/progenitor cells of hepatocellular carcinoma. Mol Cancer Ther. 2012;11:629-38. X. Xu*, R.F. Liu*, B.B. Wan, W.M. Xing, J. Huang, Z.G. Han, Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines. Mol Cell Biochem. 2011;354:11-20. (*Co-first authors)