应豪 - 同济大学

个人简介

上海市第一妇婴保健院副院长，十四五国家重点研发计划首席科学家，上海市优秀学术带头人，上海市首届医务工匠。第十届中华医学会围产医学分会常委、第四届中国医师协会妇产科医师分会委员，上海市产科临床质量控制中心主任、上海市市级医院产科专科联盟主任，上海医学会围产医学分会候任主任委员，上海市医师协会母胎医学分会副会长、上海市母婴安全委员会副主任委员。上海市医学科技奖青年奖（第一完成人）。临床重点聚焦产科急救、早产、胎盘源性疾病、产科内分泌疾病等。基础研究聚焦早产与分娩启动、滋养细胞侵袭的机制研究。临床研究聚焦围产大数据和模型构建。主持项目（近五年主持项目）基于早产发生机制的精准临床综合防控策略研究，十四五国家重点研发计划“生育健康及妇女儿童健康保障”，2022YFC2704600，2500万（首席） WTAP介导KDM6B-m6A修饰调控羊膜上皮细胞染色质重塑在分娩启动中的作用及机制研究，国家自然基金面上项目，82271719，52万早发型子痫前期发病机制及整体化防控策略的研究，十四五国家重点研发计划“生育健康及妇女儿童健康保障”，2021YFC2701600，310万（骨干）宫颈机械性损伤致流产及早产大鼠模型构建，上海2021年“科技创新行动计划”实验动物研究领域项目，21140903800，25万外泌体源的RNA去甲基化酶ALKBH5启动炎性相关分娩的作用及机制研究，国家自然基金面上项目，82071678，56万孕酮栓剂预防宫颈锥切史单胎孕妇自发性早产的随机对照研究，促进市级医院临床技能与临床创新三年行动计划重大临床研究项目，疑难疾病精准诊治攻关项目，SHDC2020CR2059B，390万 microRNA-4728靶向调控PDK1导致滋养细胞侵袭过度的作用及机制，国家自然基金面上项目，81771600，55万高龄孕产妇胎盘相关疾病早期防治策略研究，上海市“科技创新行动计划”临床医学领域项目“科技支撑项目”， 17411950600，200万剖宫产史孕妇胎盘种植异常疾病早期诊断和规范化治疗的研究，上海市新兴前沿项目，SHDC12017120， 100万剖宫产史孕妇合并胎盘植入的早期预测方法的探讨，上海市卫生计生委面上项目，201740109，20万

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Wu S, Wang L, Dong J, Bao Y, Liu X, Li Y, Liu X, Xie H, Ying H. The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis. Int J Infect Dis. 2023;128:335-346. doi: 10.1016/j.ijid.2023.01.018. Epub 2023 Jan 25. Jiang H, Guo J, Li J, Li C, Du W, Canavese F, Baker C, Ying H, Hua J. Artificial Neural Network Modeling to Predict Neonatal Metabolic Bone Disease in the Prenatal and Postnatal Periods. JAMA Netw Open. 2023 Jan 3;6(1):e2251849. doi: 10.1001/jamanetworkopen.2022.51849. Han H, Wang L, Lu W, Dong J, Dong Y, Ying H. Impacts of the COVID-19 Pandemic on Anxiety and Depressive Symptoms in Pregnant Women and Related Perinatal Outcomes. J Pers Med. 2022 Dec 30;13(1):94. doi: 10.3390/jpm13010094.PMID: 36675755 Free PMC article. Xie H, Ying H. Editorial: Advance in translational research of preterm birth and related pregnancy.Front Pharmacol. 2022 Nov 3;13:1047649. doi: 10.3389/fphar.2022.1047649. eCollection 2022 Qiao P, Fan K, Bao Y, Yuan L, Kan H, Zhao Y, Cai J, Ying H. Prenatal exposure to fine particulate matter and the risk of spontaneous preterm birth: A population-based cohort study of twins. Front Public Health. 2022 Oct 24;10:1002824. doi: 10.3389/fpubh.2022.1002824. eCollection 2022 Liu X, Liu Y, Qu C, Mol B, Li W, Ying H.The association of iron-deficiency anemia, thrombocytosis at delivery and postpartum venous thromboembolism.Am J Hematol. 2022 Jul 9. doi: 10.1002/ajh.26657. Online ahead of print. Mi YB, Liu XH, Wang WS, Wang LY, Ling LJ, Sun K, Ying H.ER-phagy Is Involved in the Degradation of Collagen I by IL-1β in Human Amnion in Parturition. J Immunol. 2022 Oct 26:ji2200518. doi: 10.4049/jimmunol.2200518. Online ahead of print. Zhihong Min, Yan Li, Hao Ying.Blood T-helper 17 cells and interleukin-17A correlate with the elevated risk of postpartum depression and anxiety. J Clin Lab Anal. 2022 Jul;36(7):e24559. doi: 10.1002/jcla.24559. Epub 2022 Jun 16. Liu XH, Cao ZJ, Chen LW, Zhang DL, Qu XX, Li YH, Tang YP, Bao YR, Ying H. The association between serum folate and gestational diabetes mellitus: a large retrospective cohort study in Chinese population. Public Health Nutr. 2022 Sep 12:1-8. doi: 10.1017/S136898002200194X. Online ahead of print. Bian Z, Qu X, Ying H, Liu X. Are COVID-19 mitigation measures reducing preterm birth rate in China? BMJ Glob Health. 2021 Aug;6(8):e006359. doi: 10.1136/bmjgh-2021-006359. Chuanlu Xu, Yirong Bao, Jia Zuo, Yuhong Li, Yuping Tang, Xiaoxian Qu, Hao Ying. Maternal chronic hepatitis B virus infection and the risk of preterm birth: A retrospective cohort analysis in Chinese women. J Viral Hepat. 2021 Aug 3. doi: 10.1111/jvh.13585. Online ahead of print. Wen-Jiao Li, Jiang-Wen Lu , Chu-Yue Zhang, Wang-Sheng Wang , Hao Ying（第二通讯）, Leslie Myatt , Kang Sun. PGE2 vs PGF2α in human parturition. Placenta. 2021 Jan 15;104:208-219. doi: 10.1016/j.placenta.2020.12.012. Epub 2020 Dec 31. Li X, Zuo J, Li YH, Tang YP, Bao YR, Ying H.Association between thyroid function and risk of gestational diabetes mellitus in assisted pregnancies: A retrospective cohort study. Diabetes Res Clin Pract. 2021 Jan;171:108590. doi: 10.1016/j.diabres.2020.108590. Epub 2020 Dec 9. Jia Y, Xie H, Zhang J, Ying H. Induction of TGF-β receptor I expression in a DNA methylation-independent manner mediated by DNMT3A downregulation is involved in early-onset severe preeclampsia. FASEB J. 2020 Aug 14. doi:10.1096/fj.202000253RR. Epub ahead of print. PMID: 32794622. Xie H, Ying H. Is the conclusion available? Letter to the Editor concerning the study of Prof. Jin titled "Clinical features and outcomes of pregnant women suspected of coronavirus disease 2019". J Infect. 2020 Aug;81(2):e130-e131. doi:10.1016/j.jinf.2020.05.076. Epub 2020 Jun 3. PMID: 32504742. Qiao P, Zhao Y, Jiang X, Xu C, Yang Y, Bao Y, Xie H, Ying H. Impact of growth discordance in twins on preeclampsia based on chorionicity. Am J Obstet Gynecol. 2020 Apr 2:S0002-9378(20)30375-6. doi: 10.1016/j.ajog.2020.03.024. Epub ahead of print. PMID: 32247845. Zheng J, Liu X, Zheng B, Zheng Z, Zhang H, Zheng J, Sun C, Chen H, Yang J, Wang Z, Lin M, Chen J, Zhou Q, Zheng Z, Xu X, Ying H. Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and Downregulated Nrf2/CBR1 Pathway in Offspring. Front Pharmacol. 2020 Feb 28;11:97. doi: 10.3389/fphar.2020.00097.PMID: 32184720; PMCID: PMC7058637. Qu X, Zhuang J, Xu C, Ai Z, Yuan L, Tang Y, Shu Q, Bao Y, Han H, Ying H. Maternal serum pentraxin 3 level in early pregnancy for prediction of gestational diabetes mellitus. Ann Transl Med. 2019 Dec;7(23):722. doi: 10.21037/atm.2019.12.25. PMID: 32042738; PMCID: PMC6990028. Qiao P, Zhao Y, Cai J, van Donkelaar A, Martin R, Ying H, Kan H. Twin growth discordance in association with maternal exposure to fine particulate matter and its chemical constituents during late pregnancy. Environ Int. 2019 Sep 10;133(Pt A):105148. doi: 10.1016/j.envint.2019.105148. [Epub ahead of print] PMID: 31518941 Wang YW, Wang WS, Wang LY, Bao YR, Lu JW, Lu Y, Zhang CY, Li WJ, Sun K, Ying H. Extracellular matrix remodeling effects of serum amyloid A1 in the human amnion: Implications for fetal membrane rupture.Am J Reprod Immunol. 2019 Jan;81(1):e13073. doi: 10.1111/aji.13073. Epub 2018 Dec 10.PMID: 30461130 Wang LY, Wang WS, Wang YW, Lu JW, Lu Y, Zhang CY, Li WJ, Sun K, Ying H. Drastic induction of MMP-7 by cortisol in the human amnion: implications for membrane rupture at parturition.FASEB J. 2019 Feb;33(2):2770-2781. doi: 10.1096/fj.201801216R. Epub 2018 Oct 10. Gu Y, Su X, Li Y, Tang Y, Bao Y, Ying H. Do free thyroxine levels influence the relationship between maternal serum ferritin and gestational diabetes mellitus in early pregnancy?Diabetes Res Clin Pract. 2019 Mar 29. pii: S0168-8227(18)31270-1. doi: 10.1016/j.diabres.2019.03.033. [Epub ahead of print]PMID: 30935929