个人简介
发表研究论文150余篇（SCI收录62篇），主编专业著作两部，主译专业著作两部。
主持上海市医学重大课题“妇科肿瘤诊疗新技术及规范化诊治方案研究”，获2012年上海市科技进步一等奖。先后主持包括9项国家自然科学基金、上海市重中之重临床医学中心和重点学科建设、上海市卫生发展重大项目基金和上海市优秀学科带头人(领军)计划项目在内的各类科研项目20余项，科研经费500余万元。
探索妇科重要手术8项，其中两项手术的成果或经验发表于SCI期刊并获奖。
在研课题
SOX17突变激活YAP/TEAD转录输出:子宫内膜癌恶性转化的新机制. 国家自然基金面上课题. 77万. 2021年-2025年. 项目编号：82172975
雌激素通过下调linRNA-NORAD介导染色体不稳定：子宫内膜癌发病假想及其机制. 国家自然基金面上课题.72万. 2020年-2024年.项目编号：81972438
上海市卵巢癌专病数据库与生物样本全息库的建立. 申康第五类项目. 237万. 2020年-2022年. 项目编号：SHDC2020CR5003-002
分子分型联合手术机器人前哨淋巴结显影新技术精准评估子宫内膜癌淋巴结状况的推广研究. 申康第十二批新兴前沿项目. 100万. 2020年-2023年. 项目编号：SHDC12020107
近期论文
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Yunfeng Song, Lei Ye, Yuan Tan, Huan Tong, Zeheng Lv, Xiaoping Wan*, Yiran Li*. Therapeutic exosomes loaded with SERPINA5 attenuated endometrial cancer cell migration via the integrin β1/FAK signaling pathway. Cell Oncol (Dordr). 2022 Aug 11. doi: 10.1007/s13402-022-00687-4. Epub ahead of print. PMID: 35951287.
Song Y, Wang M, Tong H, Tan Y, Hu X, Wang K, Wan X*. Plasma exosomes from endometrial cancer patients contain LGALS3BP to promote endometrial cancer progression. Oncogene. 2021 Jan;40(3):633-646. doi: 10.1038/s41388-020-01555-x. Epub 2020 Nov 18. PMID: 33208911.
Guo YE, Li Y, Cai B, He Q, Chen G, Wang M, Wang K, Wan X*, Yan Q*. Phenotyping of immune and endometrial epithelial cells in endometrial carcinomas revealed by single-cell RNA sequencing. Aging (Albany NY). 2021 Jan 10;13(5):6565-6591. doi: 10.18632/aging.202288. Epub 2021 Jan 10. PMID: 33429363; PMCID: PMC7993685.
Tan Y, Bian Y, Song Y, Zhang Q, Wan X*. Exosome-Contained APOH Associated With Antiphospholipid Syndrome. Front Immunol. 2021 May 4;12:604222. doi: 10.3389/fimmu.2021.604222. PMID: 34040601; PMCID: PMC8143051.
Li BL, Wan XP*. Prognostic significance of immune landscape in tumour microenvironment of endometrial cancer. J Cell Mol Med. 2020 Jul;24(14):7767-7777. doi: 10.1111/jcmm.15408. Epub 2020 May 19. PMID: 32424934; PMCID: PMC7348174.
Binya Liu, Guofang Chen, Qizhi He, Minhao Liu, Kun Gao, Bailian Cai, Junjie Qu, Shaojian Lin, Anke Geng, Shuangdi Li, Kai Wang, Zhiyong Mao, Xiaoping Wan*, Qin Yan*. An HMGA2-p62-ERα axis regulates uterine leiomyomas proliferation. FASEB J. 2020 Jun 27.
Bailian Cai, Zhiyi Hu, Huanyin Tang, Zhangsen Hu, Zhiyong Mao, Binya Liu, Xiaojun Xu, Ying Jiang, Xiaoping Wan*. Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells. Biomed Pharmacother. 2020; 129: 110427.
Tong Han, Yukang Wu, Xiang Hu, Yaqi Chen, Wenwen Jia, Qizhi He, Yiding Bian, Mengfei Wang, Xudong Guo, Jiuhong Kang, Xiaoping Wan*. NORAD orchestrates endometrial cancer progression by sequestering FUBP1 nuclear localization to promote cell apoptosis. Cell Death Dis. 2020; 11(6): 473.
Xiaoli Wen, Jing Wan, Qizhi He, Mengfei Wang, Shuangdi Li, Mei Jiang, Zhen Qian, Binya Liu, Wen Lu, Kai Wang, Kun Gao*, Xiaoping Wan*. p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer. Signal Transduct Target Ther. 2020; 5(1): 81.
Yiran Li, Yuanhui Jia, Qi Che, Qian Zhou, Kai Wang, Xiao-Ping Wan*. Correction: AMF/PGI-mediated tumorigenesis through MAPK-ERK signaling in endometrial carcinoma. Oncotarget. 2020; 11(7): 755-757.
Hu Z, Cai B, Wang M, Wen X, Geng A, Hu X, Xue R, Mao Z, Jiang Y*, Wan X*. Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer. Cell Cycle. 2020 Nov;19(22):3115-3126. Epub 2020 Oct 16. PMID: 33064975; PMCID: PMC7714470.
Yujia Huang, Qian Feng, Huabo Jiang, Wanding Zhou, Jinhong Chen, Jie Gao, Kai Wang, Xiaoping Wan*, Yongsheng Yu*. Mimicking the Endometrial Cancer Tumor Microenvironment to Reprogram Tumor-Associated Macrophages in Disintegrable Supramolecular Gelatin Hydrogel. Int J Nanomedicine. 2020; 15: 4625-4637.
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